Protein

Protein accession
A0A8S5PWL4 [UniProt]
Representative
7DMXE
Source
UniProt (cluster: phalp2_20664)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 95% (predicted by ML model)
Protein sequence
MKFSQQALNKLKEFEGFRSKAYKAVSSETYWTIGYGHYGADVNPDDVWSEEKATQVLMNQDLPAFENYVNANFSGLNQHQFDALVDFAYNCGNGNLGKSTLAKRVKANKNDKSIREAFMRWNKAGGKVLARLTKRRTWEADWYFAETPTSEMEEPNVPEDVKPEEKPNDVIANTMNNTNGTKGNSSSNQKTYTFNGPYSTSASLPPKIIQAIKPKIVVDDMVSDLPQ
Physico‐chemical
properties
protein length:227 AA
molecular weight:25539,2 Da
isoelectric point:6,76
hydropathy:-0,78
Representative Protein Details
Accession
7DMXE
Protein name
7DMXE
Sequence length
222 AA
Molecular weight
25541,63320 Da
Isoelectric point
5,90946
Sequence
MTEKGLELIKSFEGFRADAYWDSTGKVWTIGYGATFYMDGTKVSKGDRITKEEATRLLEKMVAERFEKYVDMYVTSSINPNQRDALTSFTYNCGPGNLKKSALLRKVNADPSDTSIRQEFAKWNKSGGQVLAGLTRRRKAEADLYFTPWKGVQETPVVETAVSEEKKNEPVTIEAKADIIEPETIEIVEHVENEVVVIEREPKHTPWYKRFWLWVASIFWRD
Other Proteins in cluster: phalp2_20664
Total (incl. this protein): 3 Avg length: 219,3 Avg pI: 7,34
Protein ID Length (AA) pI
7DMXE 222 5,90946
A0A6J7WCG6 209 9,36192
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_39262
3ZDlT
 646 57,8% 140 1.741E-39
2 phalp2_4451
31DIk
 4919 53,7% 147 1.557E-38
3 phalp2_9745
82S7v
 113 48,6% 148 2.129E-38
4 phalp2_40316
3fQk2
 50 42,6% 176 5.443E-38
5 phalp2_28113
7zmZV
 50 49,0% 155 3.556E-37
6 phalp2_4532
3QBcV
 9 53,7% 145 4.338E-36
7 phalp2_1915
4hcut
 54 44,6% 177 3.868E-35
8 phalp2_2632
6RhYr
 14867 49,3% 148 7.225E-35
9 phalp2_33221
5jbqV
 447 47,2% 148 1.350E-34
10 phalp2_6830
8n5Jv
 121 47,6% 149 3.445E-34

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 7DMXE (222 AA)
Member sequence: A0A8S5PWL4 (227 AA)
1 222 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctgsk7
[NCBI] 		2825151 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015533 [NCBI]
CDS location
range 15518 -> 16201
strand -
CDS
ATGAAATTCAGTCAGCAAGCATTAAACAAGTTAAAAGAATTTGAAGGTTTCAGAAGTAAAGCTTACAAAGCAGTTTCTTCTGAAACTTATTGGACCATAGGTTATGGACATTATGGAGCTGATGTAAATCCTGATGATGTATGGTCTGAAGAGAAAGCTACTCAAGTCCTCATGAACCAGGACTTGCCTGCATTTGAGAACTATGTCAATGCTAACTTTAGTGGGTTGAACCAACACCAGTTTGATGCATTAGTTGACTTTGCTTATAATTGTGGTAATGGTAACCTTGGTAAGAGCACATTAGCTAAGAGAGTCAAAGCTAACAAGAATGATAAAAGTATTAGAGAAGCTTTCATGAGGTGGAACAAAGCTGGTGGAAAAGTTCTTGCTAGATTGACAAAGAGAAGAACTTGGGAGGCTGACTGGTACTTTGCAGAAACACCTACATCAGAAATGGAAGAACCTAATGTTCCTGAAGATGTAAAACCTGAAGAGAAACCTAATGATGTGATTGCTAATACAATGAACAATACTAACGGTACTAAAGGAAATTCTAGTTCTAATCAGAAGACTTATACTTTCAATGGTCCTTATTCAACTAGTGCTTCATTACCACCTAAAATCATTCAAGCTATCAAACCAAAGATTGTAGTTGATGATATGGTTTCTGACCTTCCTCAATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7DMXE) rather than this protein.
PDB ID
7DMXE
Method AlphaFoldv2
Resolution 77.83
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50