Protein

Protein accession
A0A8S5NUM4 [UniProt]
Representative
1365V
Source
UniProt (cluster: phalp2_11558)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MNISNKGLDLIKSYEGCRLTAYKPVQTEQYYTIGWGHYGSDVYAGMTITQEQADNMLREDVKYYANAVNQYQSRFNFNQAEFDSLTSFAYNCGVGSLQAVMSCCNTKQEIAEECKLYNKGGGVVLAGLVRRREEEYKLFMSGASNNANNNDGYSYAEKGTYYFNTKVRIRTAPSLDASTIATDIQEPFYNPGESVEYHTVHRNKHGYNWIQYNRTNGTQGYCAITDLATGERFGYAE
Physico‐chemical
properties
protein length:237 AA
molecular weight:26827,3 Da
isoelectric point:5,65
hydropathy:-0,67
Representative Protein Details
Accession
1365V
Protein name
1365V
Sequence length
396 AA
Molecular weight
42855,07900 Da
Isoelectric point
8,96776
Sequence
MAKMKISENGIALIKSFEGCRLTAYKAVRTEKYYTIGYGHYGADVRAGQTISQKEADALFLTDVQKYVDYTNIYVKSFSPDQNQFDALVSFCYNCGPGTLKKLVSGRTVEEIAEHITDYTKSGGKVVNGLIRRRQEEKALFCKGSEVKSVSNKIKVGSARIDENGKLTGGKAGDQTGKEVSTQDYYLHSKGWYLLRPKSVEDADKLAASMMAACNNDNIGYDQNERLGIITQIKKYGSMAKIAVKTEADCGTLVRGCCIEAGFDPGNFTTSGEATALSKTGRFEGKIAVTSSTILHNGDVLVTKTKGHTVIVVSGNPRRVSEPMESVEIKIGQIVQFTGNRHYTSSYAKATGKSCKPGMAKVTAVNLEGAYPYHLTAVSGGGSTVHGWVNAEDVNT
Other Proteins in cluster: phalp2_11558
Total (incl. this protein): 12 Avg length: 396,7 Avg pI: 8,68
Protein ID Length (AA) pI
1365V 396 8,96776
1oe2g 416 8,85688
41az2 421 8,81181
4MgRX 404 9,02894
4MjW2 400 8,14521
4xDKg 389 9,00638
4xqid 389 9,00638
7XXsZ 433 9,22647
858Hy 431 9,23311
n3kD 413 9,15814
ocks 431 9,04474
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_6596
1jFrl
 4 52,1% 255 2.767E-80

Domains

Domains [InterPro]
GH24
Unannotated
Unannotated
Representative sequence (used for alignment): 1365V (396 AA)
Member sequence: A0A8S5NUM4 (237 AA)
1 396 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctqrl18
[NCBI] 		2825681 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015249 [NCBI]
CDS location
range 14688 -> 15401
strand +
CDS
ATGAATATAAGCAACAAAGGGCTTGATTTAATAAAGTCTTATGAAGGGTGCAGATTAACAGCATATAAACCAGTGCAAACAGAACAATATTATACTATAGGATGGGGACATTATGGTTCAGATGTATATGCAGGCATGACAATAACTCAAGAACAGGCTGATAATATGCTTAGAGAAGATGTTAAATATTACGCAAATGCAGTAAATCAATATCAAAGCAGATTTAACTTTAACCAGGCAGAATTCGACAGTTTAACGAGCTTTGCATACAATTGTGGAGTTGGTTCTTTACAAGCTGTTATGTCTTGTTGTAATACCAAGCAAGAAATAGCAGAAGAATGTAAATTATATAATAAAGGCGGGGGCGTTGTTCTTGCTGGGCTTGTAAGAAGAAGAGAAGAAGAATACAAGCTATTCATGAGTGGAGCTAGTAATAATGCTAATAACAATGATGGATATTCTTATGCAGAAAAAGGGACTTATTATTTTAACACTAAGGTTAGAATAAGAACTGCTCCAAGCTTAGATGCTTCAACTATTGCTACAGATATTCAAGAACCTTTTTACAATCCAGGAGAAAGTGTAGAATACCATACAGTACATAGAAATAAGCACGGTTATAATTGGATTCAATATAATAGGACAAATGGTACACAAGGTTATTGTGCAATAACAGACCTTGCTACAGGTGAAAGATTTGGATATGCTGAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1365V) rather than this protein.
PDB ID
1365V
Method AlphaFoldv2
Resolution 90.70
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50