Protein

Protein accession
A0A8S5N9M9 [UniProt]
Representative
77dZ
Source
UniProt (cluster: phalp2_29201)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MANLRLSKKSGAVGVVCSVGTIIAIVISAGHVRTNERGLELIGNAESCRRDPYVCPAGVLTDGIGNTHDVKAGVRKTDEQIARDWEMNILEAEKCVNSYASGKGLSDDTFSAVTSITFNVGCGAMRKSTLYSMLRDGPDAWPSACNQFTRWVYAGKTILPGLVKRRDAEKQLCLDGLK
Physico‐chemical
properties
protein length:178 AA
molecular weight:19168,8 Da
isoelectric point:8,69
hydropathy:-0,15
Representative Protein Details
Accession
77dZ
Protein name
77dZ
Sequence length
269 AA
Molecular weight
30977,69740 Da
Isoelectric point
6,46421
Sequence
MYTSQTGVNLIKEFEGLRLDSYYCSSGVLTIGYGHTGPDVWVGQIITEEQAEQFLRDDLEVFERAVEELIDIDLTQNQFDALVSFTFNCGDGALEQSTLRKRLNAGEDPNTVAEEELPRWNKGANGPLPGLTRRREAEVKLFTLEERIVELCTNYNTWLKKKTVASSKLKSNEKAKVIKGRCYKSCKIVKSEHNHTLVQFPYGMGTWWVYNEHWDGLKENKDQSKNNLGYKVLNVPYQSQRDNYTQWWRTCFSSSCAMALMYLKPNVIK
Other Proteins in cluster: phalp2_29201
Total (incl. this protein): 15 Avg length: 236,7 Avg pI: 7,78
Protein ID Length (AA) pI
77dZ 269 6,46421
165Bc 230 9,08613
1Ami8 236 4,51889
2Yikw 220 8,20587
33w3f 220 8,51281
3nuFB 248 9,06691
4fpaJ 227 6,07151
6QreU 209 8,79776
6VT7f 280 5,88667
7CppA 242 9,26683
8bPvl 252 5,72701
8t1TH 251 9,09644
GJao 227 9,07658
GbFN 261 8,26538
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_31943
7FwYi
 314 57,5% 280 7.530E-124
2 phalp2_2764
1lyD
 3 37,9% 216 1.582E-40
3 phalp2_29474
1HD6V
 2 32,0% 184 3.950E-35
4 phalp2_40631
7SPSj
 2 24,5% 228 7.654E-33
5 phalp2_28322
16R6i
 5 33,1% 187 5.136E-28
6 phalp2_33109
4K52y
 18 27,3% 168 1.240E-16

Domains

Domains [InterPro]
GH24
Unannotated
Unannotated
Representative sequence (used for alignment): 77dZ (269 AA)
Member sequence: A0A8S5N9M9 (178 AA)
1 269 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctpLW14
[NCBI] 		2826464 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015100 [NCBI]
CDS location
range 22779 -> 23315
strand -
CDS
GTGGCGAACTTGAGGCTGAGTAAGAAAAGCGGGGCTGTGGGCGTTGTGTGTTCCGTTGGCACCATCATTGCCATCGTGATAAGCGCCGGCCATGTGCGCACGAACGAGCGAGGACTGGAGTTAATCGGCAATGCTGAATCCTGTCGCCGTGACCCTTATGTCTGCCCGGCTGGAGTACTGACGGACGGAATTGGCAATACCCACGACGTAAAAGCTGGTGTCCGAAAAACGGATGAGCAGATCGCCCGCGACTGGGAAATGAATATTCTGGAAGCGGAGAAGTGCGTTAACAGCTACGCCAGCGGTAAGGGGCTCAGCGACGACACATTCTCTGCCGTCACCTCTATCACCTTCAATGTCGGCTGCGGCGCCATGAGAAAATCCACGCTCTACTCAATGCTGCGTGACGGTCCCGATGCCTGGCCTTCAGCCTGTAACCAGTTCACGCGATGGGTATACGCCGGAAAGACCATCCTGCCGGGCCTGGTTAAACGCCGTGACGCGGAGAAGCAACTCTGCCTGGATGGGCTGAAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
A0A8S5N9M9
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (77dZ) rather than this protein.
PDB ID
77dZ
Method AlphaFoldv2
Resolution 90.87
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50