Protein

Protein accession
A0A8F2JCF7 [UniProt]
Representative
7B99h
Source
UniProt (cluster: phalp2_8252)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSIKARIAAIVAASLLSAGGIAHIKLSEGRHTTAYPDPGTNGAPWTICYGHTGPEVKPGLKVSLEQCELWLLEDTAKHEKFVQNLVKVPLKQGEYDSLVSFSFNLGPGNLQSSTLLRKLNSGDRRGSCMEYPKWKYANKRVLEGLVVRRFKEQTQCLQEGPYVFRP
Physico‐chemical
properties
protein length:166 AA
molecular weight:18431,0 Da
isoelectric point:9,32
hydropathy:-0,34
Representative Protein Details
Accession
7B99h
Protein name
7B99h
Sequence length
223 AA
Molecular weight
24911,63710 Da
Isoelectric point
9,71547
Sequence
MSTLNFISTYGSVLITSLAILVAGITLVLRVQELIYKYRKERKRIKMSESAKQQDWAWKIIALGGLGLSAAGVVAISSHEGLRYTAYPDPATKAAPWTICYGHTGPEVRPGLVVTQSQCDKWLAQDLSKAEQQVRAVVKVRITQGEMDAYTSFVYNAGIGNFRGSTMLKLLNQGKRKEACDQFPRWSYANKIRLEGLAKRRYEERAMCLKGGKYVNAAIMETH
Other Proteins in cluster: phalp2_8252
Total (incl. this protein): 46 Avg length: 170,8 Avg pI: 9,08
Protein ID Length (AA) pI
7B99h 223 9,71547
1bOzU 167 9,27998
4KzH2 175 8,35892
4Rz0S 173 9,53463
5BC6J 161 7,93840
6Dovs 177 8,88292
6Dz36 175 8,26519
6ri9 161 4,60472
7BE78 174 9,53657
7b1ex 179 9,31911
7eTvq 171 9,44077
7gvEA 177 9,29926
8L7oQ 164 9,37062
8LOCn 166 9,17451
8LQZf 178 9,46733
puOS 144 7,79160
zxHn 141 4,91483
Q7Y5I9 223 9,71547
A0A1S5R1I9 164 9,08361
C4ML28 174 9,53657
I7HDJ5 179 9,31911
V5Q7S4 173 9,36199
V5Q9M8 164 9,37062
Q2NPG4 166 9,17451
A5H1N1 178 9,46733
A0A1B1SEJ4 168 9,18115
A0A5B9N870 166 9,43297
A0A6F8ZLE0 170 9,53831
A0A8E7FQ07 175 9,62121
A0AAE9C8U9 174 9,41105
A0AAU7J7Z4 179 9,36308
A0A868BZ37 169 9,31892
A0A976SH44 173 9,36205
A0A9X9JN06 173 9,45547
A0A9X9JNL4 173 9,45547
A0A9X9NYW9 168 9,31937
A0AAE7WM38 166 9,43290
A0AAE8Y9H7 166 9,43297
A0AAE8YHC0 166 9,43380
A0AAE9GBA7 169 9,34052
A0AAE9GQJ3 152 9,48228
A0AAF0AS88 150 9,41137
A0AAX4GV69 176 9,47107
A0AAX4MTZ3 166 9,32376
A0A8E6PLA2 167 9,44128
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_2632
6RhYr
 14867 47,2% 144 1.513E-55
2 phalp2_33221
5jbqV
 447 48,9% 145 2.072E-55
3 phalp2_2176
3Yhf4
 930 43,5% 156 5.921E-53
4 phalp2_28113
7zmZV
 50 44,2% 147 9.999E-52
5 phalp2_2498
5GMvl
 297 44,3% 142 9.007E-51
6 phalp2_6830
8n5Jv
 121 43,7% 151 5.332E-49
7 phalp2_6905
2wnW6
 22 38,2% 141 9.989E-49
8 phalp2_4532
3QBcV
 9 40,4% 141 3.505E-48
9 phalp2_14481
4Lj5N
 23 45,7% 140 5.903E-47
10 phalp2_126
5jCCA
 637 46,5% 144 7.260E-46

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 7B99h (223 AA)
Member sequence: A0A8F2JCF7 (166 AA)
1 223 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Stenotrophomonas phage BUCT598
[NCBI] 		2834253 Autographiviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MW831865 [NCBI]
CDS location
range 3310 -> 3810
strand +
CDS
ATGAGCATCAAGGCAAGGATCGCAGCCATCGTGGCTGCGTCCCTGCTGAGCGCCGGTGGTATTGCCCACATCAAGCTCAGTGAGGGACGGCACACCACGGCTTACCCTGATCCGGGTACCAACGGCGCACCGTGGACCATCTGTTACGGCCACACCGGCCCCGAAGTTAAGCCCGGCCTCAAGGTTTCGCTGGAACAGTGCGAGCTTTGGCTGCTGGAAGACACCGCTAAGCACGAGAAGTTCGTCCAGAATCTGGTCAAGGTTCCCCTCAAGCAGGGTGAGTACGACTCCCTCGTGTCGTTCTCGTTCAACCTTGGCCCCGGCAACCTCCAGAGCAGCACCTTGCTGCGCAAGCTTAACTCTGGCGACCGCCGGGGCAGTTGCATGGAGTACCCGAAGTGGAAGTACGCCAACAAGCGTGTCCTCGAAGGGCTCGTTGTCCGTCGATTCAAAGAGCAGACCCAGTGTTTGCAGGAGGGACCGTATGTATTCCGTCCGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
A0A8F2JCF7
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7B99h) rather than this protein.
PDB ID
7B99h
Method AlphaFoldv2
Resolution 92.74
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50