Protein

Protein accession
A0A6J7WL85 [UniProt]
Representative
7vIKE
Source
UniProt (cluster: phalp2_27796)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MAPSSNCIDLIKKFEGLFLKAYKCPAGVPTIGYGSTMWNDGKKVEMGQVITLEDAEKLLMWEVMSKTKALPKMNLTQNQHDSIISFCYNLGVGAFLKSTLYKKININPNDPSIRDEFMKWTKARVKGILTELPGLVRRRKAEADMYFNTITTNKKSKTDIIKDEKTNGLLNVFLFILSVKALIDIYLLINI
Physico‐chemical
properties
protein length:191 AA
molecular weight:21647,3 Da
isoelectric point:9,40
hydropathy:-0,10
Representative Protein Details
Accession
7vIKE
Protein name
7vIKE
Sequence length
355 AA
Molecular weight
38842,44330 Da
Isoelectric point
9,40705
Sequence
MKPSQACIDFIKSFESFYANAYLCPANVPTIGWGTTKWDLTRPVKLGEKITRAEAERQLRLEVDRVAAAVNAAVRVPLSQNQFDALVSWGYNVGTGWITGRRGSKQASFIKALNKGDYDAPVRDLPKFSRTTGGKQLSGLSRRRREEVKMWQSGAIASGRVADESDDASEGYVSRPTTAPYFDARFRQVQARLRALGYPVGAVDGLHGRASARGIAAFQRDHGLEGDAGVWYERYDDTLDTAQSVIPAERSATKTRQLTATDPLAKKLSWVEKILMWLGLGGGAAASLPDAASQATGTFSALNGVWQIIADNKALIIVAGFILAALLIRWVLTELRDAYRNNDYQGAIPSDEVRQ
Other Proteins in cluster: phalp2_27796
Total (incl. this protein): 3 Avg length: 302,0 Avg pI: 9,24
Protein ID Length (AA) pI
7vIKE 355 9,40705
2ZUI 360 8,92250
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_38866
1Mo76
 29 34,3% 314 1.566E-30
2 phalp2_22247
7g4te
 1 32,9% 264 9.828E-27
3 phalp2_10026
79q9u
 11 29,2% 243 1.036E-22
4 phalp2_34307
3A2Hz
 178 34,1% 237 1.876E-22
5 phalp2_9590
1qPJJ
 8 34,1% 252 6.149E-22
6 phalp2_1642
8qFOb
 229 34,3% 227 8.270E-22
7 phalp2_24666
5IWY5
 127 34,0% 238 1.765E-18
8 phalp2_16965
86QY9
 61 27,5% 232 3.172E-18
9 phalp2_6611
1poy8
 1 31,8% 223 4.406E-17
10 phalp2_40050
3winH
 1 26,9% 304 1.471E-12

Domains

Domains [InterPro]
GH24
PG_1
Unannotated
Representative sequence (used for alignment): 7vIKE (355 AA)
Member sequence: A0A6J7WL85 (191 AA)
1 355 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR798259 [NCBI]
CDS location
range 28206 -> 28781
strand +
CDS
ATGGCCCCATCTAGTAACTGCATCGATCTAATTAAAAAGTTTGAGGGATTGTTTTTAAAGGCATATAAATGCCCTGCAGGAGTACCTACTATAGGATATGGATCTACTATGTGGAATGATGGCAAAAAAGTAGAGATGGGGCAGGTTATTACTTTAGAGGATGCAGAAAAGCTGTTAATGTGGGAGGTAATGAGTAAAACAAAGGCATTACCTAAAATGAATCTAACACAGAATCAGCATGATAGCATCATTTCATTTTGTTATAATTTAGGGGTAGGGGCATTTTTAAAATCTACTCTATATAAAAAGATTAATATAAATCCTAATGATCCATCCATCAGGGATGAGTTTATGAAATGGACAAAGGCAAGGGTAAAAGGAATATTAACTGAATTACCGGGCCTAGTAAGGCGGCGTAAAGCTGAGGCGGATATGTATTTTAATACAATTACAACTAATAAAAAAAGTAAAACTGATATAATTAAAGATGAAAAAACTAATGGGTTATTAAATGTATTCTTATTTATATTATCAGTAAAAGCATTAATAGATATTTATTTGTTAATTAATATCTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7vIKE) rather than this protein.
PDB ID
7vIKE
Method AlphaFoldv2
Resolution 70.37
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50