Protein

Protein accession
A0A6J5MIW2 [UniProt]
Representative
5vvs4
Source
UniProt (cluster: phalp2_14618)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKMSAAGLDTVKEFEGLRLKAYKCPAAVWTIGYGHTSAAGSPIVTSDLEITREAAEEILKKDMGQYEDGVSKYVKVGLTQGQFDALVDFAYNAGVGALAKSTLLKKVNAGKFDEVPAEFMKWTKGGGKELPGLVRRRRAEVKLWRGLEEDIPVSKTQSRFQPDQPKASKKITQSKEANAAVVAGGLGTVAVVREVMPMVKEGGDLLGSLSPTILILFVIIAAAGAVWYFRKQRLDEEGA
Physico‐chemical
properties
protein length:239 AA
molecular weight:25807,5 Da
isoelectric point:9,13
hydropathy:-0,14
Representative Protein Details
Accession
5vvs4
Protein name
5vvs4
Sequence length
157 AA
Molecular weight
16857,42290 Da
Isoelectric point
8,56877
Sequence
FDALVDFAYNAGVGALAKSTLLKRVNAEKFDEVPAEFMKWTKGGGKELPGLVRRRRAEVKLWRGLETEKPVCNDEARAEPDLPVPKKSIMQSKEANGAVIAGGAGAIAVVQEVMPIVKEGGNILSAMSGTALVCLVIMVAAGAIWYFRKQRLDEDGA
Other Proteins in cluster: phalp2_14618
Total (incl. this protein): 11 Avg length: 156,7 Avg pI: 8,05
Protein ID Length (AA) pI
5vvs4 157 8,56877
1DtsO 134 9,25097
1hx2D 164 5,89735
1wWtT 157 6,58948
3bnN8 127 7,01242
48KyH 134 6,60267
53A1M 169 8,68352
5iGoY 110 9,22293
6LzXL 120 9,66157
A0A6J5NA53 213 7,92931
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_34047
8e5e3
 8 35,4% 155 1.046E-19
2 phalp2_10966
4MkR6
 70 34,3% 157 4.487E-18
3 phalp2_6008
4MOEK
 54 35,4% 161 2.933E-17
4 phalp2_26378
1q5mp
 207 35,4% 158 1.185E-12
5 phalp2_30561
5EHHM
 5 31,9% 166 1.941E-11
6 phalp2_23338
5xKRF
 1 36,5% 123 4.922E-11
7 phalp2_118
5dvo1
 1 32,3% 136 9.148E-11

Domains

Domains [InterPro]
GH24
Disordered region
Representative sequence (used for alignment): 5vvs4 (157 AA)
Member sequence: A0A6J5MIW2 (239 AA)
1 157 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796466 [NCBI]
CDS location
range 16334 -> 17053
strand +
CDS
ATGAAAATGTCTGCCGCTGGTCTGGATACAGTCAAGGAGTTCGAAGGTCTTAGACTAAAGGCGTATAAATGTCCTGCGGCTGTCTGGACTATCGGCTACGGTCATACGTCAGCGGCGGGTTCGCCAATAGTCACAAGCGACCTTGAGATCACGCGGGAAGCTGCCGAGGAAATCCTCAAGAAGGACATGGGTCAATATGAAGATGGCGTCAGCAAGTATGTCAAAGTCGGACTTACGCAGGGTCAATTTGATGCGCTCGTTGATTTTGCTTACAATGCTGGTGTCGGCGCTCTTGCTAAGTCCACACTGCTGAAGAAGGTCAACGCTGGTAAGTTCGACGAAGTTCCAGCCGAGTTTATGAAGTGGACCAAAGGCGGCGGCAAAGAGCTTCCCGGTCTGGTGCGTCGCCGTCGTGCAGAGGTCAAGCTGTGGCGTGGTCTGGAAGAAGACATCCCGGTATCCAAAACACAGTCACGGTTCCAGCCCGATCAGCCCAAGGCATCTAAGAAGATCACCCAGTCCAAGGAGGCAAACGCTGCGGTAGTGGCTGGCGGGTTGGGTACTGTTGCGGTCGTGCGGGAAGTTATGCCAATGGTCAAAGAGGGTGGCGATTTGCTAGGCTCACTGAGCCCGACAATCCTGATCCTGTTCGTCATCATCGCTGCGGCAGGTGCTGTATGGTACTTCCGCAAGCAGCGTCTGGATGAGGAGGGCGCATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5vvs4) rather than this protein.
PDB ID
5vvs4
Method AlphaFoldv2
Resolution 78.06
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50