Protein

Protein accession
A0A6J5LDR3 [UniProt]
Representative
48EM7
Source
UniProt (cluster: phalp2_31530)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MTMHMSPEGINTLLKPFEGCKLNSYRCPANVLTVGYGHTSAAGAPEVIEGMKITQAQANTILASDLVKFEKGVEALLKQQVTQGQFDVLVDFAYNAGLGNLKNSGILKKVNAAQFDAVPAELMKWNKGKIPGKGMQVLPGLVKRCQARSLWWTTHSSAPIDEQELRVTPEPIPQKTMAESKQGNAALVTAGLGSLGIAKEVAAQAQDASDTANQLMGLLHNPNFLIMAAVIGLGAAIWFWRKKHMDEYGV
Physico‐chemical
properties
protein length:250 AA
molecular weight:26913,9 Da
isoelectric point:8,68
hydropathy:-0,08
Representative Protein Details
Accession
48EM7
Protein name
48EM7
Sequence length
99 AA
Molecular weight
10593,08650 Da
Isoelectric point
5,09371
Sequence
MRMSAEGLGLVKEFEGLRLKAYKCPAAVWTIGYGHTSAAGAPTVNPGMEITKEEAEAILKRDMVQYEAGVEKLVKVELTQGQFDALVDFAYNAGVGALA
Other Proteins in cluster: phalp2_31530
Total (incl. this protein): 20 Avg length: 112,2 Avg pI: 7,44
Protein ID Length (AA) pI
48EM7 99 5,09371
18TfU 71 7,85446
1vDoe 70 6,06889
1yCyT 109 6,55924
27enh 124 5,66198
2V84O 121 10,24914
3g8Ao 147 10,30922
48j5V 85 4,64547
4V9k6 174 8,89801
4VKeo 95 7,84253
4eWJF 148 10,17738
4l6hS 94 6,03337
5kBNk 79 5,28309
67CG 106 6,69628
6y0r4 78 7,73223
7eH5T 89 6,81769
7w3RA 89 8,88318
8DMvl 139 8,84779
8tMyp 76 6,54429
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33221
5jbqV
 447 58,7% 97 8.206E-44
2 phalp2_4451
31DIk
 4919 57,1% 98 1.491E-39
3 phalp2_31263
8mZo1
 167 58,5% 99 1.251E-37
4 phalp2_36488
1js3Z
 12 55,5% 99 1.717E-37
5 phalp2_26644
2b0IA
 24 55,4% 92 1.442E-35
6 phalp2_4289
84eDR
 22 53,0% 83 1.662E-33
7 phalp2_31105
1YRHZ
 456 52,4% 101 1.018E-31
8 phalp2_39262
3ZDlT
 646 50,5% 89 3.310E-30
9 phalp2_20450
3rDzg
 26 43,1% 95 8.555E-30
10 phalp2_9019
535M3
 35 47,3% 95 2.211E-29

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 48EM7 (99 AA)
Member sequence: A0A6J5LDR3 (250 AA)
1 99 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796242 [NCBI]
CDS location
range 52486 -> 53238
strand -
CDS
ATGACCATGCACATGAGCCCAGAGGGCATCAATACCCTCCTCAAACCGTTTGAAGGCTGCAAGCTAAACAGTTATCGCTGCCCGGCAAACGTGCTAACGGTGGGCTATGGGCACACCTCCGCCGCTGGCGCCCCCGAAGTGATTGAAGGCATGAAGATCACGCAGGCGCAGGCGAACACTATCCTCGCTTCCGATCTTGTGAAGTTTGAGAAGGGCGTCGAGGCGCTGCTGAAGCAGCAGGTCACGCAGGGGCAGTTCGACGTTCTCGTGGACTTTGCCTACAACGCTGGCCTTGGAAATCTCAAAAATTCTGGCATCCTCAAGAAAGTTAACGCCGCGCAGTTCGATGCGGTTCCCGCCGAGTTGATGAAATGGAACAAGGGCAAGATACCGGGGAAGGGTATGCAAGTTCTTCCGGGCCTTGTGAAGCGTTGCCAAGCGCGATCGCTCTGGTGGACTACCCATTCCAGCGCCCCTATCGACGAGCAAGAGCTTCGTGTCACACCTGAACCAATCCCTCAGAAGACAATGGCGGAGAGCAAGCAGGGTAACGCTGCGCTGGTCACGGCTGGCCTTGGAAGCCTTGGAATTGCGAAGGAGGTCGCTGCGCAGGCGCAGGATGCGTCTGACACGGCAAATCAGCTCATGGGTCTTCTTCACAACCCGAACTTCCTCATCATGGCTGCGGTCATTGGGCTCGGCGCCGCGATCTGGTTCTGGCGCAAGAAGCACATGGACGAGTACGGTGTTTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (48EM7) rather than this protein.
PDB ID
48EM7
Method AlphaFoldv2
Resolution 94.84
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50