Protein

Protein accession
A0A6G5YJP0 [UniProt]
Representative
7s4x2
Source
UniProt (cluster: phalp2_13857)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTRQISQHGLEKLKQWEGLKTKAYKDAGGVWTIGYGHTAAAGTPAPHQGMVITEADAESILLKDLTQYEAAVENNVNVKLNDNEFAALVSFAFNVGINAFKNSALLKKLNKGNFDAVPSELMKWVKAGGKKLQGLVNRRRAEGYLWMEGAFVASKDVVPEQKTVHPVLKPEVIGPVISAASGLTGFATGSGPFQWALAAVMVIGVAIGSFYFIKRLREAEL
Physico‐chemical
properties
protein length:221 AA
molecular weight:23873,3 Da
isoelectric point:9,30
hydropathy:-0,02
Representative Protein Details
Accession
7s4x2
Protein name
7s4x2
Sequence length
134 AA
Molecular weight
14412,46580 Da
Isoelectric point
9,55404
Sequence
LFSFCYNVGTTAFCNSTLLKKLNNGEYEAVPAELQKWTKAGGKRLQGLVHRRVAEAGLWAKGTYVSSNYQTVETKDSTALFKAEALAPVIGSFSGLGGLLAGNGPVQWALATIMVLAAGVGLFFVAKRFQEHRL
Other Proteins in cluster: phalp2_13857
Total (incl. this protein): 6 Avg length: 206,5 Avg pI: 9,52
Protein ID Length (AA) pI
7s4x2 134 9,55404
A0A6G5XUW6 221 9,64313
A0A6G5Y0R7 221 9,45501
A0A6G5Y3B2 221 9,49801
A0A6G5YEC3 221 9,67098
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_30334
4CJ0A
 8 36,1% 141 8.088E-23
2 phalp2_29354
11yhI
 7 32,0% 103 2.388E-11

Domains

Domains [InterPro]
GH24
Disordered region
Representative sequence (used for alignment): 7s4x2 (134 AA)
Member sequence: A0A6G5YJP0 (221 AA)
1 134 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Caudoviricetes sp
[NCBI] 		2832643 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN856063 [NCBI]
CDS location
range 4574 -> 5239
strand +
CDS
ATGACGCGACAAATCAGCCAACACGGTCTTGAAAAACTGAAACAATGGGAAGGTCTCAAAACCAAAGCCTATAAGGATGCCGGCGGCGTCTGGACAATCGGCTACGGGCACACGGCAGCGGCTGGAACGCCCGCACCACACCAAGGAATGGTTATCACCGAAGCCGACGCGGAAAGCATTCTCCTGAAAGATCTTACGCAATATGAAGCGGCTGTCGAGAATAACGTCAATGTCAAACTCAACGACAATGAATTTGCCGCTCTTGTATCCTTTGCTTTCAACGTCGGCATCAATGCTTTCAAAAATTCTGCACTTCTCAAAAAACTCAATAAAGGCAATTTTGATGCGGTTCCGTCTGAACTGATGAAATGGGTCAAAGCAGGGGGCAAAAAGCTTCAAGGACTTGTCAATCGGCGGCGGGCTGAAGGGTATCTCTGGATGGAAGGCGCTTTTGTCGCTTCCAAAGATGTCGTGCCGGAACAAAAAACTGTTCATCCGGTGTTGAAGCCGGAAGTCATCGGGCCGGTTATCAGCGCCGCTTCCGGCTTGACCGGTTTTGCCACCGGTTCGGGGCCTTTCCAATGGGCGTTAGCGGCCGTCATGGTTATCGGCGTTGCAATCGGCAGTTTCTATTTCATTAAACGATTGAGAGAGGCGGAATTATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7s4x2) rather than this protein.
PDB ID
7s4x2
Method AlphaFoldv2
Resolution 81.43
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50