Protein

Protein accession
S4U9Y8 [UniProt]
Representative
8H1gU
Source
UniProt (cluster: phalp2_30830)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVKYTVENKIIAGLPKGKLKGANFVIAHETANSKSTIDNEVSYMTRNWKNAFVTHFVGGGGRVVQVANVNYVSWGAGQYANSYSYAQVELCRTSNATTFKKDYEVYCQLLVDLAKKAGIPITLDSGSKTSDKGIKSHKWVADKLGGTTHQDPYAYLSSWGISKAQFASDLAKVSGGGNTGTAPAKPSTPAPKPSTPSTNLDKLGLVDYMNAKKMDSSYSNRAKLAKQYGIANYSGTASQNTTLLSKIKGGAPKPSTPAPKPSTSTAKKIYFPPNKGNWSVYPTNKAPVKANAIGAINPTKFGGLTYTIQKDRGNGVYEIQTDQFGRVQVYGAPSTGAVIKK
Physico‐chemical
properties
protein length:341 AA
molecular weight:36432,9 Da
isoelectric point:9,81
hydropathy:-0,48
Representative Protein Details
Accession
8H1gU
Protein name
8H1gU
Sequence length
341 AA
Molecular weight
36402,82780 Da
Isoelectric point
9,80585
Sequence
MVKYTVENKIIAGLPKGKLKGANFVIAHETANSKSTIDNEVSYMTRNWKNAFVTHFVGGGGRVVQVANVNYVSWGAGQYANSYSYAQVELCRTSNATTFKKDYEVYCQLLVDLAKKAGIPITLDSGSKTSDKGIKSHKWVADKLGGTTHQDPYAYLSSWGISKAQFASDLAKVSGGGNTGTAPAKPSTPAPKPSTPSANLDKLGLVDYMNAKKMDSSYSNRAKLAKQYGIANYSGTASQNTTLLSKIKGGAPKPSTPAPKPSTSTAKKIYFPPNKGNWSVYPTNKAPVKANAIGAINPTKFGGLTYTIQKDRGNGVYEIQTDQFGRVQVYGAPSTGAVIKK
Other Proteins in cluster: phalp2_30830
Total (incl. this protein): 43 Avg length: 327,5 Avg pI: 9,39
Protein ID Length (AA) pI
8H1gU 341 9,80585
1cfG4 322 9,78541
1cfJv 327 9,76543
2O7F 421 5,99341
2Yw4e 363 10,06849
2lpjs 438 8,78461
2pwwp 260 9,57415
33mY 438 8,48593
3R5x 363 7,09927
3nIOJ 370 9,84163
78N3m 313 9,70373
78x2h 354 9,99481
7Gf7Q 247 5,65437
7e1Rm 307 9,71018
7rc0o 240 8,84753
7wEI7 234 8,60706
7x5Ag 233 8,37723
8M9yf 341 9,80585
gApk 238 9,17819
A0A5C2IBZ1 341 9,80585
A0A068CCD7 161 9,31815
A0A068CCC4 341 9,80585
A0A059T6U5 341 9,80585
A0A059T8F6 341 9,80585
A0A059T8J1 341 9,80585
A0A060AFE7 341 9,78632
A0A068CAR6 341 9,81829
A0A076G560 341 9,80585
A0A088FNU9 341 9,80585
A0A514U7N6 341 9,80585
A0A6H2A7G0 341 9,80585
A0A6H2A7Z4 341 9,80585
A0A6M9YZV3 341 9,80585
A0A7G9A520 341 9,80585
A0A7G9A5L8 341 9,80585
A8ASR3 341 9,77426
B6DQH9 309 9,73635
B6DQI8 309 9,73635
J3RJW9 334 9,76582
M4GZZ1 341 9,80585
Q30LD5 341 9,80585
Q38653 341 9,77426
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_10019
74ect
 1 38,4% 234 7.134E-48
2 phalp2_23617
eRWW
 1 38,0% 213 6.624E-35
3 phalp2_35269
6SkGy
 26 34,5% 223 8.759E-33
4 phalp2_27725
6UNCq
 90 28,6% 395 4.583E-31
5 phalp2_29156
7qyOK
 47 27,4% 295 7.441E-24
6 phalp2_22264
7pxLN
 64 20,1% 278 2.686E-06

Domains

Domains [InterPro]
Ami2
Unannotated
Unannotated
Representative sequence (used for alignment): 8H1gU (341 AA)
Member sequence: S4U9Y8 (341 AA)
1 341 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Listeria phage LP-125
[NCBI] 		1173766 Herelleviridae > Pecentumvirus > Pecentumvirus LP0832
Host Listeria monocytogenes
[NCBI] 		1639 Firmicutes > Bacilli > Bacillales > Listeriaceae > Listeria >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
JX126918 [NCBI]
CDS location
range 48446 -> 49471
strand +
CDS
ATGGTAAAATATACCGTAGAGAACAAAATTATTGCAGGATTACCTAAAGGTAAACTAAAAGGGGCTAACTTTGTTATTGCTCATGAAACTGCAAATAGCAAGTCTACTATTGACAATGAAGTAAGCTACATGACTAGGAACTGGAAGAACGCATTTGTAACTCACTTTGTAGGTGGCGGAGGTAGAGTCGTTCAGGTTGCTAATGTAAACTATGTTTCTTGGGGAGCAGGTCAGTATGCTAACTCTTATTCCTATGCGCAGGTAGAGTTGTGCCGTACAAGTAATGCAACTACATTTAAGAAAGACTATGAAGTGTACTGTCAATTACTAGTAGACCTAGCTAAAAAAGCAGGTATCCCTATTACACTTGACTCTGGTAGTAAAACTAGTGATAAAGGTATTAAATCCCATAAATGGGTTGCTGATAAGCTAGGAGGAACAACACACCAAGACCCATATGCTTACTTAAGCTCATGGGGTATTAGTAAAGCACAATTTGCTAGTGACTTGGCTAAAGTATCTGGCGGAGGAAACACAGGAACAGCGCCAGCTAAACCAAGCACACCAGCACCTAAACCAAGCACACCATCTACTAACCTAGACAAACTTGGCTTAGTAGACTACATGAACGCTAAGAAAATGGACTCTAGCTACAGTAACAGAGCTAAATTAGCTAAACAGTATGGTATTGCTAACTATTCAGGAACAGCTAGCCAGAACACTACACTCCTTAGTAAAATTAAAGGAGGAGCACCTAAACCAAGCACACCAGCACCTAAACCTAGTACATCTACAGCTAAGAAAATTTATTTCCCACCAAATAAAGGAAACTGGTCTGTGTATCCAACAAATAAAGCACCCGTTAAGGCTAATGCTATTGGTGCTATTAACCCTACTAAATTCGGAGGATTGACTTACACTATCCAAAAAGATAGAGGAAACGGTGTATACGAAATCCAAACAGACCAATTCGGCAGAGTTCAAGTCTATGGTGCACCTAGTACAGGAGCAGTTATCAAAAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
A0A059T6U5
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A059T8F6
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A059T8J1
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A076G560
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A088FNU9
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50

Showing first 5 of 15 structures.

The structures below correspond to the cluster representative (8H1gU) rather than this protein.
PDB ID
8H1gU
Method AlphaFoldv2
Resolution 82.65
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50