Protein

Protein accession
R4JHA2 [UniProt]
Representative
8MRZu
Source
UniProt (cluster: phalp2_39755)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSFRIVNGNTHTEKGWRCCNRDECDIVRIPGLYLTDTAPIRKGAPLTILGAWLYWYDRNVEEIVTPIWGWSLDNDVLGQPGKNNGSNHLSGVAVDVNAPKYPWGTYRMSADKIAKVEEGLRLFEGTVFWGRRWSKPDEMHYDLSYPEGDPRNEAFAKKLLDGYLGIYKPATQVSAAPILAAATGLSEARAAEILPAVRSGLRESECTNVNRIAMWLAQIGHESGSFQYTEEIAKNGRYAPYIGRTWIQITWDYNYRSFSQWAYAFGMVPTPDYFVVNYRELADLKWAGIGPAWYWTVARPDINELSDRRDLNTVTRRINGGTNGLADRQARYNRALAQGDALLQLLHEEDDFLSALTDAEQRELLDLARQQAKYKRKSRSPLHWPHEGEVDTIAGLSWSTDANVHIQLVEKLAVIYGDPVSIALLYAVSNSDDPTNNPELAKRILKRVKPEDITAAQVQIQKWLAAEQKFHAA
Physico‐chemical
properties
protein length:473 AA
molecular weight:53475,6 Da
isoelectric point:6,06
hydropathy:-0,44
Representative Protein Details
Accession
8MRZu
Protein name
8MRZu
Sequence length
519 AA
Molecular weight
57857,97150 Da
Isoelectric point
5,00606
Sequence
MSFRVVNGNTHTENGWRCCNRDECGIVDIADLFLTETAPLRNGAPLIILGAWLFWYDRNVEEIVSSVWGWSLNNDVLGQPGRNNGSNHLSGTAVDVNAPKYPWGLYRMTDDKIAKVREGLELFQGSIFWGRRWGELGVSKADEMHYQMAWPEGDPRNEAFAEKLRNGYLGIYGTDTGTETPSSPRKPVVPGQGGTFWNDVSQYQVKPIDESYPHKVFSFRTNSGDVTDTLALQNARAAKTLLDSGQLEIVIPYYFFRPGQANCDLHREILETAGLFNHPRTVSMVDVEGDKGSVKGDNSIEINDEVTRMRGWYGSNDRVIGYLNSNADPNLWPTRNGINLVVPQYGRTPGDISSIKDATVRTDAIAHQYTSTATDQSPWIGRSVDANWSPYDLSELLALFGIQKAEGLFMYLTKDEEFAIRDKILGYKSMGNKWPARGIFADSLEGVDDTVGMLLNSDGNIWDVLVILGALSGVSEHISRIERLANGQGPRGKEERFVKIAQELLRFIQAKDEGTEDNA
Other Proteins in cluster: phalp2_39755
Total (incl. this protein): 55 Avg length: 428,8 Avg pI: 6,02
Protein ID Length (AA) pI
8MRZu 519 5,00606
4M8tn 518 5,27013
8MS1A 522 5,02016
A0A2L1IWT7 519 5,00606
A0A5Q2WFY0 472 5,94396
A0A411BRR3 482 6,35144
U5NZY5 225 6,22401
G8I5V5 473 6,05508
W8FPK3 482 6,19576
A0A515MM52 473 6,24492
A0A1B1PCT5 472 6,00444
A0A481VSH7 226 6,52849
V5R928 473 6,19218
A0A3G2KG67 522 5,02016
A0A0K1LRS8 473 6,19218
A0A0K1LTD6 473 6,05508
A0A0K2CLB2 485 6,11243
A0A1L6BY60 473 6,05508
A0A1L6BZ44 473 6,05508
A0A2L0HK03 473 6,05508
A0A2P1A164 473 6,05508
A0A2P1CE32 473 6,05508
A0A2P1CGN0 473 6,05508
A0A2P1N3B0 473 6,05508
A0A2Z5HF97 473 6,05508
A0A345KKQ5 473 6,11192
A0A345KPK5 473 6,05508
A0A385DVK0 226 6,52849
A0A386KNG9 225 6,22844
A0A411BND8 473 6,05508
A0A4D6T9Q1 473 6,05508
A0A4Y5TXM6 473 6,05508
A0A514DH66 226 6,52849
A0A5B8RQY2 473 6,19218
A0A5Q2WGH6 473 6,05508
A0A6B9LEW7 473 6,05508
A0A6B9LI91 226 6,53020
A0A6M3SWZ9 226 6,52673
A0A6M3T5F5 473 6,05508
A0A7G8LEP4 473 6,05508
A0A7G8LH55 473 6,11192
A0A7G8LPS2 522 5,15134
A0A7U0J6D3 473 5,87979
G1JTQ9 473 6,05508
A0A8A1VBL3 218 5,82960
A0A8A1VES4 222 5,96783
A0A8A1VG37 218 5,82960
A0A8F3E638 473 5,93350
A0A976SRZ9 473 6,24492
A0A9E7QKG2 471 6,29551
A0AAE7VBH6 225 6,52832
A0AAU8GKY1 471 6,29551
A0AAU8GQ87 473 6,19218
B3VGP8 473 5,93350
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_30503
5hxHI
 19 30,7% 508 1.661E-62
2 phalp2_1213
8JrjH
 54 30,4% 371 1.185E-27

Domains

Domains [InterPro]
Unannotated
Unannotated
Unannotated
Representative sequence (used for alignment): 8MRZu (519 AA)
Member sequence: R4JHA2 (473 AA)
1 519 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage PattyP
[NCBI] 		1327773 Fromanvirus >
Host Mycobacterium smegmatis str. MC2 155
[NCBI] 		246196 Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KC661273 [NCBI]
CDS location
range 4371 -> 5792
strand +
CDS
GTGAGCTTCCGGATCGTCAACGGGAACACCCACACCGAGAAGGGATGGCGGTGCTGCAACCGGGACGAGTGCGACATCGTCCGCATCCCCGGCCTGTATCTAACCGACACAGCACCCATCCGTAAGGGAGCTCCGCTAACCATTCTCGGGGCGTGGCTGTACTGGTACGACCGCAACGTCGAGGAGATCGTCACCCCGATCTGGGGCTGGTCCCTTGATAACGACGTACTAGGGCAGCCGGGGAAGAACAACGGGTCTAACCACCTGTCCGGGGTAGCTGTGGACGTCAACGCGCCCAAGTACCCCTGGGGCACGTACCGGATGTCTGCGGACAAGATTGCCAAGGTCGAGGAAGGACTTCGGCTGTTCGAAGGGACAGTCTTCTGGGGACGGCGCTGGTCAAAGCCCGACGAGATGCACTACGACCTCTCGTACCCCGAAGGCGACCCTCGAAACGAAGCCTTCGCGAAGAAGCTCCTGGATGGGTACCTCGGGATTTACAAGCCCGCTACCCAGGTGTCCGCAGCCCCCATCCTGGCGGCGGCCACCGGCCTGAGCGAAGCTCGCGCGGCGGAGATCCTGCCCGCGGTCCGCTCGGGCCTCCGGGAATCCGAATGCACGAACGTCAACCGCATCGCGATGTGGCTGGCTCAGATCGGGCATGAGTCCGGGTCATTCCAGTACACCGAGGAGATCGCCAAGAACGGTCGGTACGCGCCGTACATCGGCCGGACGTGGATTCAGATCACCTGGGACTACAACTACCGGTCGTTCTCGCAGTGGGCGTACGCGTTCGGGATGGTTCCGACTCCGGACTACTTCGTCGTGAACTACCGCGAGCTCGCTGACCTGAAGTGGGCGGGCATCGGCCCTGCCTGGTACTGGACGGTCGCCCGCCCGGACATCAACGAGCTGTCCGATCGCCGCGACCTGAACACGGTCACCCGCCGGATCAACGGCGGCACCAACGGCCTCGCGGATCGACAAGCCCGCTACAACCGCGCGCTCGCCCAGGGCGATGCGCTGCTGCAACTACTTCACGAAGAGGACGACTTTTTGTCTGCTCTAACCGACGCTGAACAGCGTGAGTTGCTGGACCTGGCTCGCCAGCAGGCCAAGTACAAGCGCAAGTCCCGCTCGCCGCTGCACTGGCCGCACGAGGGCGAGGTCGATACGATCGCCGGCTTGTCCTGGTCGACGGACGCGAACGTCCATATCCAGCTGGTCGAGAAGCTCGCTGTGATCTACGGCGACCCGGTCTCGATCGCGCTGCTGTACGCGGTGTCGAACTCCGACGATCCGACGAACAACCCCGAGCTGGCGAAGCGCATCTTGAAGCGCGTCAAGCCCGAGGACATCACCGCTGCTCAGGTCCAGATCCAGAAGTGGCTGGCTGCCGAGCAGAAGTTCCATGCCGCTTAA

Gene Ontology

Description Category Evidence (source)
GO:0008233 peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000218e85e_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (8MRZu) rather than this protein.
PDB ID
8MRZu
Method AlphaFoldv2
Resolution 85.83
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50