Protein

Protein accession
O64298 [UniProt]
Representative
8IEyq
Source
UniProt (cluster: phalp2_30831)
Protein name
Orf288 gp
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MTRRYTKMNVPQSLVNWFVNHRNLLTYSMYGSRNGSDGTADCSGSMSQALKEAGIPIQGLPSTVTLGQQLAKNGFYRISRNEDWNAETGDIVLMSWGADMASSGGAGGHVGVMMDSVNFISCDYSTQGAAGQAINTYPWNDYYEANKPAYIEVWRYSESAPQTKNQANTAVTPQQKAYYEANEVKYVNGIWQIKCDYLSPIGFDYLENGIPVTMVNWVDKDGNDLPDGADQDLKAGMYFSFSSDETNIVDTGNGGYYGGYYWRLFEFGQFGPVWLSCWNKDDLVNYFQ
Physico‐chemical
properties
protein length:288 AA
molecular weight:32178,2 Da
isoelectric point:4,53
hydropathy:-0,49
Representative Protein Details
Accession
8IEyq
Protein name
8IEyq
Sequence length
200 AA
Molecular weight
21820,90700 Da
Isoelectric point
4,82111
Sequence
MSVQQSIVNWFVNHRGQLTYSMYGSRNGSDGTADCSGSISQALKEAGIAIQGLPSTVTLGKQLANNGFYRVSINQDWNAETGDIVLMSWGADMSSSGGAGGHVGVMMDSVNFISCDYSTQGAPGKAINTYPWNDYYAANKPSYIEVWRYSDSAPQTNNQANTAVVPQSKAYYEANEVKYVNGIWQIKCDYLCPIGFDWVN
Other Proteins in cluster: phalp2_30831
Total (incl. this protein): 212 Avg length: 240,3 Avg pI: 4,67
Protein ID Length (AA) pI
8IEyq 200 4,82111
11Bq2 284 6,11846
1Z1bk 281 5,08603
1Z1uk 287 4,18616
1gPnV 233 8,59675
20y7R 200 4,76768
2kVP1 281 5,11320
2kVqj 281 4,99805
5Mqly 281 4,49917
5P74P 162 4,68503
5Rnvh 127 4,31837
5TEw8 281 4,30785
6Yyxv 281 4,08481
6bA9p 281 4,92160
6l019 281 5,00879
6ngsV 281 4,44750
6uGY7 200 4,98367
725AQ 284 4,75381
7JC1g 281 4,57317
7NVsz 201 4,52316
7OzYh 281 4,08515
7QkRD 200 4,44648
7QlwE 200 4,64087
7ULjA 236 5,09626
7cyqy 200 5,30913
7kSQ3 254 9,09715
7o4sm 248 5,63390
7o4uL 277 5,74690
7uQAH 219 4,33701
7wYf2 238 8,91470
7xeka 237 8,91470
88KnB 146 4,38845
88Y38 284 4,26494
8IEwy 281 4,93240
8IEx2 281 4,35713
8IExK 281 4,26784
8IExO 281 4,37697
8IExb 281 4,26897
8IEyF 199 4,74960
8IEyH 200 4,66719
8IEyK 200 4,66719
8IEyL 199 4,64468
8IEyM 200 4,45410
8IEyl 200 4,98367
8LLWy 281 4,50451
8LLX2 200 4,64087
8Mm65 200 4,76768
8k43O 147 4,43381
8oPoI 281 5,31805
8s7uX 187 4,88158
JTTm 208 4,40283
JU9b 200 4,79382
O3ud 180 4,31848
eRXp 264 5,35852
q1xk 200 4,44966
wJvM 147 4,34832
wPl4 281 4,08447
wW2l 281 4,08913
A0A286QMV9 200 4,82111
A0A3G8FDG2 281 4,30785
A0A286QRI1 200 4,64724
O80189 288 4,52952
A0A4D6A6K2 281 4,63723
B3GW20 283 4,34923
A0A3S5X5X3 200 4,66878
A0A191KBF9 200 4,64087
A0A4D6ATB4 200 5,30913
A0A2P0VGB0 281 4,35713
A0A2P0VI94 281 4,48780
A0A286QQE2 281 4,34252
A0A2P0VI32 281 4,45228
A0A286QQS9 281 4,39430
A0A286QRB7 281 4,31399
O21982 288 4,52952
A0A286QRM7 281 4,36998
A0A2P0VFZ2 281 4,40243
A0A286QRD2 281 4,41454
W6LMV8 281 4,24573
C5IUL1 281 4,26784
A0A286QT49 281 4,16399
A0A1S5PRV1 281 4,37697
A0A286QNK3 281 4,37856
A0A1S5PS05 281 4,35008
A0A2P0VJV4 281 4,31399
C9WB87 281 4,29938
A0A286QS74 281 4,26897
A0A4D6B0N5 284 4,61063
A0A286QMZ7 281 4,39623
A0A286QMJ6 281 4,41982
A0A2P0VI55 281 4,36355
A0A286QR44 281 4,50298
A0A286QRQ3 281 4,31211
A0A1S5PRZ0 281 4,24601
A0A286QN25 281 4,40027
A0A2P0VIM3 281 4,33525
L0P533 281 4,35037
A0A286QRV9 200 4,48519
A0A2P0VJP4 200 4,84464
A0A286QT03 200 4,69384
A0A191KC27 200 4,64087
A0A286QQX3 200 4,76768
A0A3G8FAE2 199 4,74960
C9W9J6 200 4,66719
A0A286QPZ7 200 4,66719
A0A3S5H1Z2 200 4,79485
A0A2I6QQX8 200 4,66719
A0A286QRP3 199 4,64468
A0A286QN60 200 4,45410
A0A1L2JXR0 200 4,64087
A0A286QPV9 200 4,82111
A0A240FHV4 200 4,46723
A0A286QPJ9 200 4,98367
A0A286QR96 200 4,82111
A0A1L2JXL6 200 4,66878
A0A286QQI6 200 4,78484
A0A2I6QR37 200 4,34963
A0A286QNW5 200 4,82111
Q9XJB8 200 4,64087
Q9MCJ0 281 4,18786
A0A191KBX4 200 4,76768
A0A2P0VGB4 82 9,42716
A0A286QNN9 281 4,35713
A0A286QTI1 281 4,26897
A0A2I6QQP3 281 4,41124
A0A2P0VHY1 281 4,52776
A0A2U7VK07 200 4,64087
A0A2U7VK18 200 4,64087
A0A3G6K3W4 281 4,25971
A0A3G8F6B0 281 4,39623
A0A3G8F6N9 200 4,82111
A0A3G8F6V1 200 4,82111
A0A3G8F796 200 4,84464
A0A3G8F7A2 281 4,41562
A0A3G8F7G9 281 4,37907
A0A3G8F7L2 281 4,40215
A0A3G8F7Q7 200 4,61398
A0A3G8F7Z5 281 4,42488
A0A3G8F815 200 4,64087
A0A3G8F898 200 5,02953
A0A3G8F8E0 200 4,50770
A0A3G8F8P4 281 4,28483
A0A3G8F8T5 200 5,05273
A0A3G8F974 200 4,81053
A0A3G8F9A0 200 4,82111
A0A3G8F9B1 281 4,33616
A0A3G8F9H7 200 4,71828
A0A3G8F9U6 200 4,82111
A0A3G8FA49 200 4,50770
A0A3G8FAH1 281 4,43244
A0A3G8FAT6 281 4,28483
A0A3G8FAV5 200 4,74199
A0A3G8FAW1 281 4,44733
A0A3G8FBA9 200 4,50770
A0A3G8FBB3 281 4,28256
A0A3G8FBN0 200 4,50770
A0A3G8FBN5 200 4,50770
A0A3G8FBS4 200 4,50770
A0A3G8FBX3 200 4,45410
A0A3G8FBZ7 281 4,16399
A0A3G8FC65 281 4,43244
A0A3G8FCB0 200 4,74199
A0A3G8FCL0 200 4,50770
A0A3G8FCP4 281 4,39760
A0A3G8FCV4 281 4,38589
A0A3G8FD49 281 4,30978
A0A3G8FDN2 281 4,34099
A0A3G8FDP2 281 4,45665
A0A3G8FE41 200 4,66719
A0A3G8FE73 200 4,50770
A0A3G8FF14 281 4,45665
A0A3G8FFK2 200 4,79485
A0A3S5H0B8 281 4,18872
A0A3S5H0J4 200 4,79485
A0A3S5H0W5 281 4,43244
A0A3S5H183 200 4,81963
A0A3S5H1D4 200 4,79485
A0A3S5H1R4 200 4,66878
A0A3S5H1W7 281 4,28256
A0A3S5H244 200 4,79485
A0A3S5H272 200 4,50770
A0A3S5H2A0 281 4,44733
A0A3S5H2E6 281 4,44733
A0A3S5X4F6 281 4,44733
A0A3S5X4H4 281 4,41454
A0A3S7W842 281 4,36486
A0A3S7W889 281 4,31734
A0A3S7W8K6 281 4,36486
A0A3S7W8T4 200 4,79485
A0A3S7W913 200 4,79485
A0A3S7W9F9 200 4,66878
A0A3S7W9X7 281 4,46802
A0A3S7WA38 200 5,00436
A0A3S7WA54 200 4,84464
A0A3S7WBF7 281 4,44733
A0A3S7WBZ9 281 4,48098
A0A451EFQ3 200 4,66878
A0A451EHH6 281 4,14415
A0A451EHL6 200 4,48132
A0A4D6AV63 286 4,37549
A0A7R6NGR4 281 4,23635
A0A7R6NGS6 179 4,39010
A0A7R6NH36 200 4,39766
Q9MCH6 288 4,56726
Q9T1D5 288 4,48240
A0A6G5XXS3 288 4,64400
A0A975LYC7 200 4,82111
A0AAD0LIX5 281 4,39623
A0AAD0LKD0 200 4,98367
A0AAD0LLW4 281 4,22293
A0AAD0LMC1 281 4,25908
A0AAD0PMI6 200 4,66724
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_13886
7C1QD
 360 66,8% 199 3.803E-84
2 phalp2_9275
76k47
 345 35,6% 171 2.081E-31
3 phalp2_632
1csV3
 60 33,5% 149 1.083E-28
4 phalp2_30683
6W6ka
 7 31,5% 184 1.183E-21
5 phalp2_28643
7orrE
 9 27,0% 211 2.820E-16
6 phalp2_20987
7y6FJ
 38 29,6% 165 2.431E-13
7 phalp2_20154
415G3
 53 34,1% 173 9.498E-12
8 phalp2_12594
1nLjj
 56 29,0% 172 3.210E-11

Domains

Domains [InterPro]
Ami5
Disordered region
Representative sequence (used for alignment): 8IEyq (200 AA)
Member sequence: O64298 (288 AA)
1 200 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF05382

Taxonomy

  Name Taxonomy ID Lineage
Phage Moineauvirus Sfi19
[NCBI] 		72638 Aliceevansviridae > Moineauvirus >
Host Streptococcus thermophilus
[NCBI] 		1308 Firmicutes > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
AF115102 [NCBI]
CDS location
range 23507 -> 24373
strand +
CDS
ATGACAAGGAGGTATACTAAAATGAATGTCCCACAATCTCTTGTTAATTGGTTTGTCAATCACCGCAATCTGCTTACCTACTCGATGTATGGCTCACGTAATGGATCAGACGGAACAGCCGACTGCTCTGGTTCTATGTCACAAGCCTTAAAAGAGGCAGGCATTCCTATCCAAGGGCTACCATCTACTGTCACACTTGGTCAACAACTTGCTAAAAATGGCTTCTATCGTATAAGTCGTAATGAAGACTGGAATGCTGAAACTGGTGATATCGTATTGATGTCGTGGGGCGCAGACATGGCTAGCTCTGGGGGAGCTGGTGGACACGTTGGTGTAATGATGGATAGCGTAAACTTTATTTCTTGTGACTACTCAACTCAAGGAGCAGCAGGGCAAGCTATCAATACGTATCCGTGGAATGATTACTATGAAGCTAATAAGCCTGCATATATCGAGGTTTGGCGCTATTCTGAATCAGCACCACAAACCAAAAACCAAGCGAATACAGCAGTAACTCCACAACAAAAGGCTTACTATGAAGCCAATGAAGTCAAATACGTTAACGGCATTTGGCAGATTAAATGTGATTATTTAAGCCCAATTGGGTTTGATTATTTGGAAAACGGAATCCCGGTTACAATGGTTAACTGGGTTGATAAAGATGGAAACGACCTTCCAGATGGAGCAGACCAAGATTTAAAAGCTGGAATGTACTTTTCATTCTCTAGTGATGAAACCAACATTGTAGACACTGGCAACGGTGGATACTACGGCGGATATTATTGGCGACTGTTCGAGTTTGGACAATTCGGTCCAGTATGGCTATCTTGTTGGAATAAGGACGACTTGGTAAACTATTTCCAATAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000009bd8f_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (8IEyq) rather than this protein.
PDB ID
8IEyq
Method AlphaFoldv2
Resolution 87.41
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50