Protein

Protein accession
O03950 [UniProt]
Representative
7u45O
Source
UniProt (cluster: phalp2_38217)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MKLKNKLLLTGSATMAALFLGMNANAQTLSSQSIPDISEFQNSLTVASAKQLKGESGGVILRTGYGENRKDYHIDANLKAAISAGLPYGIYQYGQFINASDARSEARAAYNRAPHAQFYVNDAEEYTTTSGSYAAAVQAWASEMRKLTKKPIVLYSYRSFYNLYIKSSTGYDAKWIAAYQKSMPAPYDYEMWQNENAHYFLSLKQATDASKIVTSKHSLSWWFGNTVNTSKYPNGGYKVGDKVHLKAGITYYGTTTKADDSLTKTKLTVKAVKTVYTGTSSQVLTVYNGSKVIGQVRAQDVTKVGSSTPSKPSNSAKWVKESKHYTLKTAVKLRTGASTSSNVITTLPAGTTVKTDQAIIQGGYRWVRQPRFNGHGYLATGPSSNTLEYVETSASHAYYTVVSGDSWWKIAQRNGLSMYTLASQNGKSIYSTIYPGNKLIIK
Physico‐chemical
properties
protein length:442 AA
molecular weight:48510,1 Da
isoelectric point:9,71
hydropathy:-0,43
Representative Protein Details
Accession
7u45O
Protein name
7u45O
Sequence length
266 AA
Molecular weight
29251,44220 Da
Isoelectric point
9,83976
Sequence
VGAVLATDVEAKEQGILSQATNDRNNAAFMKEIQKFGYRADIYTSGSWANNKMTIKGKTGWVAGYPFVPAGKQWYTNNNAWQWSGSAHFRISYGGFDVSQLYTDYYTAGQKSTVKPTNKDAVKANNQEANKNTSKPSNSAKWVKESKTYALKTAVKLRTGASTASSVIAILPAGTTVKTDQAIIQNGYRWVRQPRFNGYGYLATGPVSNTLEYVKSGAAHTYYTVKSGDSWWSIAQHNGLSMTTLASQNGKMIYTTIYPGQRLVVR
Other Proteins in cluster: phalp2_38217
Total (incl. this protein): 5 Avg length: 338,6 Avg pI: 9,81
Protein ID Length (AA) pI
7u45O 266 9,83976
5HEV8 348 9,83016
7qPYB 347 10,01582
7xJhG 290 9,63378
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17635
6JmE3
 482 64,5% 265 2.902E-106
2 phalp2_144
5oGmc
 8 30,9% 197 1.025E-26
3 phalp2_25839
5j1l4
 12 27,2% 283 2.213E-25
4 phalp2_38172
72d4D
 103 32,9% 231 3.434E-22
5 phalp2_10110
c1k0
 16 30,0% 246 3.128E-18
6 phalp2_29108
6ZCjl
 6 29,1% 182 9.589E-16
7 phalp2_9283
7cTgF
 101 24,6% 264 7.815E-15
8 phalp2_26548
858CP
 728 26,8% 268 1.421E-14
9 phalp2_15728
3kqKZ
 1 25,7% 214 2.083E-13
10 phalp2_5407
2G2v9
 4 25,0% 276 2.083E-13

Domains

Domains [InterPro]
Unannotated
Unannotated
LysM
Representative sequence (used for alignment): 7u45O (266 AA)
Member sequence: O03950 (442 AA)
1 266 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage phig1e
[NCBI] 		52979 No lineage information
Host Lactobacillus
[NCBI] 		1578 Firmicutes > Bacilli > Lactobacillales > Lactobacillaceae >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
X90511 [NCBI]
CDS location
range 1354 -> 2682
strand +
CDS
GTGAAACTCAAAAATAAACTATTACTGACGGGATCAGCCACCATGGCGGCTCTTTTTTTAGGCATGAATGCCAATGCTCAAACATTAAGTAGCCAGTCCATTCCTGATATTAGTGAATTTCAAAATTCTTTAACAGTGGCATCTGCCAAACAATTAAAGGGTGAATCTGGTGGCGTTATTCTGCGTACGGGTTATGGTGAAAATCGAAAAGATTATCATATTGATGCCAATTTAAAAGCAGCTATTTCGGCGGGGTTGCCTTATGGGATTTACCAGTACGGTCAATTTATCAATGCCAGTGATGCTCGGTCTGAAGCTCGGGCGGCATATAATCGGGCACCACATGCACAATTTTATGTTAACGATGCTGAGGAATACACCACTACAAGTGGCAGCTATGCAGCAGCGGTTCAAGCGTGGGCTTCGGAAATGAGAAAACTAACTAAGAAGCCAATTGTATTGTATAGTTACCGTTCTTTTTATAACTTGTATATCAAATCGAGCACGGGTTATGATGCGAAATGGATCGCGGCTTATCAAAAATCAATGCCAGCGCCTTATGATTATGAGATGTGGCAGAATGAAAATGCGCATTACTTCTTATCTTTGAAACAAGCAACAGATGCCAGCAAGATTGTTACTTCAAAGCATTCACTAAGTTGGTGGTTTGGTAATACGGTTAATACTTCCAAATACCCGAATGGTGGCTATAAGGTGGGTGATAAAGTTCATCTAAAGGCCGGTATTACTTACTATGGTACGACCACTAAAGCAGACGACTCACTTACTAAGACTAAATTAACCGTCAAGGCAGTTAAGACCGTCTACACTGGAACATCAAGCCAAGTGCTCACTGTTTACAATGGCAGCAAAGTGATCGGGCAAGTTCGTGCGCAGGATGTAACTAAGGTTGGGTCAAGCACACCGTCCAAGCCATCTAATTCAGCCAAGTGGGTTAAGGAGTCGAAGCATTACACGCTCAAGACTGCGGTCAAGCTGCGCACAGGCGCATCAACGTCATCAAACGTGATCACGACTTTACCTGCTGGAACTACGGTCAAAACTGATCAAGCTATCATTCAAGGTGGCTATCGGTGGGTACGCCAGCCACGATTTAATGGACACGGCTATCTAGCAACCGGCCCATCAAGCAATACGCTGGAATACGTCGAAACTAGTGCTTCTCACGCGTATTACACGGTCGTTTCAGGCGACTCATGGTGGAAGATTGCCCAACGGAACGGATTAAGCATGTATACGCTGGCGAGTCAGAACGGCAAATCAATCTATAGTACGATTTATCCTGGCAACAAGTTGATTATCAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi000009b9bd_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7u45O) rather than this protein.
PDB ID
7u45O
Method AlphaFoldv2
Resolution 82.83
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50