Protein

Protein accession
K4JRA8 [UniProt]
Representative
4PrSU
Source
UniProt (cluster: phalp2_28766)
Protein name
Putative NlpC/P60 family cell wall peptidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 95% (predicted by ML model)
Protein sequence
MTRDDIVTEARRYVALQTPWRHRGRTERGLDCIGLAVMIFEKFNLEYMDQDGYARTPDGEKFVEVIRQHMTLADPTALKPGMLLLFNDDARPCHVGILARQHGRLTLIHATADKKRTVEEVYDRRYAARFRMAFDFPGVED
Physico‐chemical
properties
protein length:141 AA
molecular weight:16384,6 Da
isoelectric point:6,97
hydropathy:-0,48
Representative Protein Details
Accession
4PrSU
Protein name
4PrSU
Sequence length
140 AA
Molecular weight
15987,02330 Da
Isoelectric point
9,17973
Sequence
MRNDVVEEARRWIGTRWRHQGRNEHGIDCAGLIIVVASKFGLQDTNPNNYPRRTSGDKFVEYFRAAGMVDVPFTHRLPGDVILTRASGFPCHCGFFSQKRGEDHYIHGYALRRKVVEEPLAVWVPDITHVLRFPKIEGGA
Other Proteins in cluster: phalp2_28766
Total (incl. this protein): 248 Avg length: 143,0 Avg pI: 8,12
Protein ID Length (AA) pI
4PrSU 140 9,17973
11Hsj 145 9,55056
11Ici 154 8,57837
13j5m 154 8,57857
14cgE 138 9,46256
16Biq 154 9,49795
17be9 104 6,64092
17dZq 172 10,00293
1IyY0 143 9,40666
1NGr5 142 7,08603
1lKHT 144 6,69855
1lyym 137 6,49990
1oSnL 166 8,71866
1pBBE 106 6,55021
1pmaA 135 6,94916
1qZ06 138 9,65577
1reky 142 7,02282
1rkgH 124 9,37417
1rvcJ 123 10,02408
1slVm 140 8,36305
1wWYH 141 8,38174
1ywPQ 162 8,29355
2AhlB 144 7,09387
2B8vb 154 7,13019
2I4Li 145 8,50888
2JiW 140 9,15743
2Mb2G 143 8,60468
2QyC8 131 11,25877
2SoWN 141 9,05022
2V842 148 9,17264
2aCM6 141 9,02462
2ce7S 148 7,08654
2ce7X 144 9,54450
2kYKF 144 7,83692
2kZtu 141 6,50729
2l1Pc 145 7,81004
2naBp 141 9,65493
2ns48 147 5,66306
2s40k 141 9,03616
2tAl6 149 8,41108
34A5p 139 7,81410
34yZT 139 7,75752
35HT3 144 9,65777
35dzi 144 8,57857
389Iq 142 9,38352
389KA 142 9,61548
3AYqD 140 7,89088
3BdaU 142 6,88857
3GF3y 149 9,57841
3NPeF 138 9,48080
3NfeF 148 6,53850
3NgGH 148 6,17950
3NhBA 148 7,13275
3NhrG 153 6,34263
3Nojt 143 7,09756
3NpR3 153 6,49496
3NqMp 143 6,69873
3O3vU 158 6,39736
3O4fO 143 8,66089
3Ojon 138 9,48080
3OkQw 143 7,09728
3Om0D 153 7,88972
3OncX 148 7,09791
3QVjd 143 6,70367
3R3Ab 143 6,69827
3R8Oo 148 6,74681
3UQ4c 188 6,95388
3VN2 140 7,68568
3X7lS 154 8,87912
3XixO 154 6,34234
3Y6qA 141 9,09560
3YPkk 149 7,15281
3anpn 144 8,59294
3bx7i 163 7,68664
3dIIm 125 8,65619
3dLrV 146 8,97640
3e4TB 136 9,49995
3e5Co 149 9,60709
3eGcP 141 8,51197
3eql4 138 7,16566
3fguo 144 7,83106
3lCaT 137 9,37295
3yRCT 144 8,83812
3zyME 144 7,08830
40wy4 139 9,41356
43Ku 146 8,91367
44SiH 143 9,03416
48mIk 143 7,86870
48mrP 157 9,68001
48n31 152 6,64069
48n3E 145 8,98846
4AZ5w 161 6,51002
4Ajuu 145 6,58772
4BHG8 145 9,69264
4Bdoa 133 8,54685
4EoFd 143 7,06846
4EoNd 143 7,93014
4Eomw 127 11,14460
4JHYf 149 9,72449
4JuXm 151 8,45169
4JzAT 143 7,96928
4KCxp 141 8,59488
4LgxZ 139 6,20514
4M8FA 146 9,56003
4OGCM 138 7,77219
4OQXX 154 8,57857
4Qn7s 142 8,68036
4Qnar 140 7,87554
4QyZS 166 8,93089
4SUVb 140 7,96721
4U02a 129 6,69799
4Uc60 138 7,09666
4UcWm 138 7,09842
4UmL2 143 9,09605
4Vjhw 142 6,74283
4VkhR 138 6,74545
4Vkxq 138 7,09842
4WmVa 138 7,09563
4Wob4 140 7,12121
4WpGS 154 9,40492
4XnmN 138 7,09842
4YPIc 144 7,09285
4b50 149 6,78631
4cgb2 152 7,76070
4dZ2Z 138 6,05292
4f5L0 150 9,57737
4faeB 137 7,71347
4fhXb 139 9,29539
4gHSy 150 9,29584
4gHYN 150 9,29584
4grQa 141 7,77105
4qBEv 159 8,68745
4sdU7 138 7,21437
4uFZO 124 9,81146
4xfmt 143 6,48780
53zzl 154 8,98614
5DlN9 126 6,63876
5ErlP 154 8,98510
5FnYz 144 8,56090
5GLY9 154 7,80546
5HWzc 103 6,30261
5Hp3g 124 10,32115
5Hpqt 146 9,25123
5HptD 144 7,12286
5IOTz 144 7,18146
5IQyI 144 8,54272
5JkZG 144 6,69765
5Jl9I 144 7,08762
5jimB 141 7,01196
5klsT 168 7,79308
5lDtx 136 6,29875
5nHEr 141 8,96344
5nIOW 151 8,67482
5yXxz 143 6,70810
6BK6D 126 6,88874
6DK5Q 142 7,01174
6IWl7 145 6,48797
6PF28 145 7,70426
6PFCB 145 9,12848
6PHb0 146 8,40179
6PKEd 149 7,85510
6PlMk 124 8,93353
6Q0a0 145 8,51848
6Q10q 138 9,54959
6QL49 142 6,95916
6R0H3 144 8,98543
6R1vM 123 10,18815
6R9t1 143 9,18083
6RLAr 147 8,49463
6RkCs 133 8,58160
6S6ck 140 6,50127
6VymK 137 6,64285
6W5zQ 142 6,28619
6WVRV 144 7,18027
6WzLm 140 7,70625
6XR09 141 7,84156
6wYTl 159 8,64381
6x46f 160 9,21190
72b6B 154 8,59713
72sBf 137 9,83022
7A0JL 140 6,64587
7B0lb 142 8,98614
7CCht 153 6,05809
7IqJy 141 6,85600
7LQLQ 145 9,54179
7PuHA 141 6,20144
7Tx0z 141 8,97537
7cbcr 154 8,57857
7dAke 119 11,22899
7dAm9 119 10,97621
7dScj 154 8,98549
7dSe8 154 8,57857
7dVY8 134 8,49463
7dzL0 119 11,18605
7dzwI 119 10,63085
7escf 144 8,55175
7jVXB 149 6,42965
7jVZD 154 8,59733
7lxrq 149 6,74647
7oN9v 154 8,57857
7pisz 154 7,85626
7rK5y 154 8,59733
7sken 144 6,78523
7vXfZ 154 8,57857
7vXff 152 7,84324
7vav5 103 5,85916
7w053 123 10,52487
7w8DO 138 7,91628
7yjgx 124 9,63856
7zPYz 140 6,58715
80cBM 142 9,16587
84WJa 145 7,73496
86JjF 145 9,73487
877yy 147 8,97647
88CBR 142 8,79963
8DbsI 145 8,39754
8Jxjl 141 6,96888
8LpMx 140 6,64587
8LpUS 140 6,94660
8caH2 154 8,59733
8ewSm 154 9,01740
8odlU 162 5,96869
8qog8 141 8,59281
9tQr 154 7,85626
Qdhp 154 8,59733
SmXT 138 9,68852
UXS5 144 7,82429
WBon 140 8,78087
YoIn 143 6,97508
Yqe7 143 6,59249
ZTjm 141 8,97369
bur3 138 7,75764
d8to 147 8,91470
dfxU 124 10,21239
dgNm 124 9,81146
dgQy 123 10,02408
ffA 140 7,63913
i8Ol 142 6,43079
jAyZ 144 9,11971
pJcV 144 7,82403
tnH2 141 7,05670
u1RY 143 9,17993
yc2C 154 7,13019
Q5DN20 142 8,98614
K4JMZ6 141 6,20144
A0A1V0ECN7 141 6,96888
A0AB74UIM2 141 6,96888
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_38771
1fCGD
 1216 39,5% 139 6.961E-49
2 phalp2_20469
3OKnd
 174 33,1% 151 2.753E-39
3 phalp2_19724
4MrB2
 69 27,5% 145 8.072E-37
4 phalp2_33260
5BBWg
 36 31,5% 152 6.093E-34
5 phalp2_29511
1Z7BX
 61 34,4% 151 9.484E-32
6 phalp2_922
7oz39
 3811 33,3% 144 4.591E-31
7 phalp2_201
5IaYc
 48 36,4% 107 2.021E-29
8 phalp2_36512
1oWEW
 304 34,7% 118 5.205E-29
9 phalp2_38782
1j4UU
 4 27,7% 137 4.731E-28
10 phalp2_28794
7FpgX
 23 36,2% 113 1.218E-27

Domains

Domains [InterPro]
Unannotated
Representative sequence (used for alignment): 4PrSU (140 AA)
Member sequence: K4JRA8 (141 AA)
1 140 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Caulobacter virus Karma
[NCBI] 		1211641 Shapirovirus >
Host Caulobacter vibrioides
[NCBI] 		155892 Proteobacteria > Alphaproteobacteria > Caulobacterales > Caulobacteraceae > Caulobacter >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
JX100811 [NCBI]
CDS location
range 68136 -> 68561
strand +
CDS
ATGACCCGCGACGACATCGTGACCGAAGCGCGCCGCTATGTCGCGCTCCAAACCCCCTGGCGTCATCGAGGCCGCACCGAACGCGGCCTCGACTGCATCGGGCTGGCCGTCATGATCTTCGAGAAATTCAACCTGGAATACATGGACCAGGACGGTTACGCGCGCACGCCCGACGGCGAGAAGTTCGTCGAGGTGATCCGCCAGCACATGACCCTGGCCGATCCGACGGCGCTCAAGCCGGGCATGCTGCTGCTGTTCAACGACGACGCCCGGCCCTGCCATGTCGGCATCCTGGCGCGCCAGCACGGACGCCTGACCCTGATCCACGCGACCGCCGACAAGAAGCGGACGGTCGAGGAAGTCTATGACCGCCGCTATGCCGCCCGGTTCCGCATGGCCTTCGATTTCCCCGGCGTTGAGGACTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008234 cysteine-type peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi00028a5662_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (4PrSU) rather than this protein.
PDB ID
4PrSU
Method AlphaFoldv2
Resolution 86.96
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50