Protein

Protein accession
G8EY22 [UniProt]
Representative
48DOP
Source
UniProt (cluster: phalp2_10824)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MISFAYNLGSGFYGSQGFETISQKLRAKDWQAVPDAMLLYRNPGSSFEAGLKRRRQSESKLWKGGDQSPPTETAKLRPESAFSSRLTPHITLGEFALNLEERRFNEQHQLDTAATLAAFLERVRGRFGGKPVIITSGYRPPAINRSVGGASGSEHLYPPGAGAVDFYLQGADIYAVQEWCDQNWPHSLGYGANRGFIHLGVRKGGPRIRWDY
Physico‐chemical
properties
protein length:212 AA
molecular weight:23552,1 Da
isoelectric point:9,51
hydropathy:-0,54
Representative Protein Details
Accession
48DOP
Protein name
48DOP
Sequence length
247 AA
Molecular weight
27732,00980 Da
Isoelectric point
8,74786
Sequence
EADMLLRQEVDRIADKLRATVPHWGEMADHQKCALISFAYNLGSGFYGSRGFETISKRLREKDWPGVPDALLLYRNPGTNVEAGLKRRRIAEGDLWGRERQTTGPIEATFTPESPFSFKITPHITYGEFALNQEARRFDHQHQCDTAVKLAQFLEKVRVQFGGKPIIITSGYRPAAINRAVGGASQSEHLYDAPGVGAVDFNIIGADINAVQDWCDRQWPYSLGYGAPKGFVHLGIRQGSPRVRWIY
Other Proteins in cluster: phalp2_10824
Total (incl. this protein): 67 Avg length: 317,6 Avg pI: 8,55
Protein ID Length (AA) pI
48DOP 247 8,74786
154dX 354 5,50664
15bqW 362 6,66894
16qCV 350 8,62788
1JKi7 353 9,25980
1NLvR 352 9,32517
1Pf5U 355 9,21964
1XRxz 171 9,87335
1YlvW 201 9,29649
1jwMM 354 9,33568
2Ij0b 350 8,96866
2JaMy 202 6,20030
2JaS4 250 7,97295
2K0Rs 251 6,67491
33yhd 308 8,69345
33ziL 349 9,06285
3XOFS 196 9,43735
3XSij 359 9,07265
4A39c 358 9,54546
4DDSj 352 9,11256
4DTA3 348 8,84708
4IZlC 384 9,12635
4ce02 351 9,14576
4jrZj 354 8,99890
4o4o0 352 7,20380
4zQVe 360 9,45914
5FaJd 183 7,90133
5Hqhd 350 8,85069
5HuK8 351 8,80208
5HuQJ 350 8,79209
5d60f 388 9,32472
5lvM8 365 8,90755
5lwWu 286 9,19005
5lwxs 334 9,29823
5mx0X 350 8,98678
5zmLu 349 9,04351
5znSt 363 8,89891
5zoA5 397 9,25033
5zp6M 353 8,85958
5zrDe 356 9,27212
5zvKU 350 9,07620
5zxoQ 361 8,86178
5zyfZ 362 9,27167
6GQDl 220 8,91090
6Ivej 321 6,56390
6LTLD 321 6,27624
6MBjV 238 9,19076
6MEK3 238 9,05028
6MFnO 353 9,09644
6My47 350 8,82374
6VQTI 383 9,20913
7TtIq 189 5,46623
7XgED 332 9,11836
81qVP 351 9,29797
8BNVd 206 5,61833
8rVLe 349 9,05299
8sCdO 355 6,27078
A8H2 224 9,67730
AMda 295 8,34854
AYwq 352 8,99890
Dy7o 298 8,42661
Frx4 383 9,25265
jWdr 355 6,27283
sTPd 354 9,01405
swiG 335 8,97647
tIwi 196 6,54526
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_1022
6SXkR
 694 80,9% 247 2.818E-134
2 phalp2_17125
2HBub
 15 70,1% 151 1.478E-79
3 phalp2_16330
5ni24
 119 26,4% 321 4.544E-23
4 phalp2_20566
4xp9r
 4 26,5% 256 2.042E-18
5 phalp2_15772
3TMNr
 7 22,5% 319 3.684E-09

Domains

Domains [InterPro]
GH24
PET_M15
Representative sequence (used for alignment): 48DOP (247 AA)
Member sequence: G8EY22 (212 AA)
1 247 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF08291

Taxonomy

  Name Taxonomy ID Lineage
Phage Synechococcus phage S-CAM8
[NCBI] 		754038 Kyanoviridae > Neritesvirus > Neritesvirus scam8
Host Synechococcus sp. WH 7803
[NCBI] 		32051 Cyanobacteria > Oscillatoriophycideae > Chroococcales > Synechococcus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
JF974299 [NCBI]
CDS location
range 157793 -> 158431
strand +
CDS
TTGATCAGTTTTGCCTACAACCTCGGTTCTGGATTTTATGGATCACAAGGTTTTGAGACGATCAGTCAAAAGCTTCGTGCGAAAGACTGGCAAGCAGTTCCTGACGCGATGCTGTTGTATAGAAACCCTGGGAGCAGTTTTGAAGCCGGTCTGAAAAGACGTAGGCAATCGGAAAGCAAGCTCTGGAAAGGCGGCGATCAGTCACCGCCGACTGAAACTGCCAAGTTGCGTCCTGAATCTGCATTTTCTAGCAGGTTGACACCGCACATCACGCTGGGCGAATTTGCGCTGAACCTAGAAGAGCGACGGTTCAATGAGCAGCATCAGTTGGATACTGCCGCAACTCTGGCGGCATTCCTAGAGCGTGTCCGTGGCAGGTTTGGGGGGAAGCCGGTAATCATTACGTCTGGCTACAGACCACCCGCGATCAATCGATCAGTCGGCGGAGCCAGCGGTTCAGAGCACCTGTACCCACCAGGCGCTGGCGCTGTGGATTTCTATTTGCAGGGGGCTGATATTTACGCGGTACAAGAATGGTGTGACCAAAATTGGCCGCACAGTCTTGGTTATGGTGCGAATCGTGGATTTATCCACCTAGGCGTCAGGAAGGGCGGCCCTAGGATACGCTGGGACTACTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

PDB ID
upi000235cbef_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (48DOP) rather than this protein.
PDB ID
48DOP
Method AlphaFoldv2
Resolution 92.83
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50