Protein

Protein accession
G1BRV1 [UniProt]
Representative
728Ni
Source
UniProt (cluster: phalp2_1049)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MALLGSLTADSSFDDVGEAIVRECLRRGYPPTKTIACVSTAIQESYLRPRARSANGLWVGIYQQDTSYPKREDPNENIREFLNRLDVKCASAGASPDPWKNIFWLQQRPGEKSAEDAYRNGRQAYLTEIKSRVNQATVLFEKYSGGEVIVAERPDFNEYAIWSPNRSSRNGVKPTMFLLHTQEGNGNADSLAKYFTSANQVSYHYTISKGANDDGVTVVDCVDTDYAAWSVGNANSRSINLCFAGSFASWTREQWLAKAGRAIDVAAYLAVQDAKKYGFSTLVVPPPYSNGTPGISDHRWVTDVFKWGTHTDVGPGFPWDVLAASVAKYTGQAQAPAAPSFAYPSTDVMIREIWEQLRGPQGKGWPQLGKNAKGENLTLVDAIAELKAAS
Physico‐chemical
properties
protein length:390 AA
molecular weight:42874,4 Da
isoelectric point:6,47
hydropathy:-0,43
Representative Protein Details
Accession
728Ni
Protein name
728Ni
Sequence length
1394 AA
Molecular weight
147152,31580 Da
Isoelectric point
5,41507
Sequence
MTETVELARVLVSLWPEASHLDEGVEKIADKAEKRFGRSGKVMGQQLASGLDEGTRRAESGLKKVEAASKKVQVARKAEADAAGRLVVAEARLEDVRKKASVSAGQRKAAEESVERARRAQVLATDNLTRALRDQHRAEQDNAAGHRDAATAVNVLGGALGKAGSAADRFGSGGNVLGSMLGRLSTGASGLSEALGSAETGAAALGAVAGTVAGAGLAALGAGAAAAMKQLYDLGESYDEVFDKLRLKTGATGPELEGLKQATMEIANQVPLTTGEIGSMTAQVNKALGQTADGLVEVTTNIANLSRIAEEPIDVRQLGKVFKAYSLKDAKEQVAALNSFKNASQSTQIPVNELIGLAAKGGPAMRQLGMDLGKATAMMGVFEEAGMEPEKIIAPLTKGLGTLAKKGQSGPEALRTLTNEIQRLIDVGDEAGAINLGNKLFGGRGGLQFVDAIRRGVFDVKKLDEALSHTGTTIQEDVEATDDFAQQWQILKNKAAGALQPLSSEVFDFTNEALGGLGDWVSEHQSDLVKFFSLMAEGAVDAGRHVIIFAADMMTAVGDIIAAAGDVAGTWMQLRGVWDQVLGNDDKAQQNFKRAQDFFAWQSGPDSLFEKAKKWKDAANSGADELNKKLDEAGNQTAQALKFTEKLGKAKASLGDDKTTVYIDSNAPEVTDKLAKIGIQVKELPDGKFEVNANTEEGQKTLDAWRQKQGGKKLEVPVTVDTKQAQEDWDNFKRNITAPAPASSPPPGDWSTLMLPPPAAPRARGGIYDVWDSVASFAGGKLPRTAMFQPPVAGAGLVQWAEPSTGGEAFIPIRGGKRSIDIWAKTGQMLGVFDQGGFNNVSQDEVNRMGGGTVNLSILRALREANPSAVLTSAKTDHGVDGGYHPKGMAIDVDPSRRNLDALWSMRDQLAQIIFDDPQKVWYNVNGEHAEGQAARRIYGESTMKQHGDHIHVAALHEIGSYGQMPGGGRYEQQSVGLGQLTPNSSPDDVASAILGEATRRGYSQDEAIAVLSTAMQESGLNPKASGGGGAWHGVFQQDTSYGGRDDPNQNIGEFFNRLDEKRRSGGSSKDIWKDIFWLQQAPGAASAEAAYSGGRQAYKTEIQSKAGAASAAYSRLGGGGGGVSGYGYQRMPATPGYDDDGRPGYYRPDAKQVREAQERVTDADQRVRDADLRVKEAEAKQKELTAAATDLEVERAQNAVDRAKNDAAKARREAGDAREDLSEAQRGKFTANKGSKGSGPDGQNFAKDMLSGALDALGFDGEIFSNPMDWGIWKLFTGGANYLGGLAKNAFGGPQRGNFPGLAGGPLGSEDGGLSGMNFGDGGGISSAGDTIASVLPQVSDFLPNSQTQAPPSVDQSINITGNVGMDPAALKSEIHTEQNARSRTYASGLPRP
Other Proteins in cluster: phalp2_1049
Total (incl. this protein): 27 Avg length: 634,1 Avg pI: 5,91
Protein ID Length (AA) pI
728Ni 1394 5,41507
3NROp 1394 5,44383
3NS2d 1393 5,45969
6PhKh 1394 5,41439
7gOss 1204 5,12400
7pMJl 1394 5,40234
7qfnp 1152 5,83085
A0A6B9JAC6 389 5,40319
A0A1D8EPE3 389 5,39558
A0A0M5M2Y5 389 5,71939
A0A291I9S1 389 5,55177
A0A222ZNF4 390 6,46750
A0A386KAF4 390 6,15887
A0A3S9UPF9 390 6,15887
A0A411BPJ3 390 6,15887
A0A482JBU9 390 6,15887
A0A482JC58 390 6,15887
A0A514U504 390 6,15887
A0A5Q2W9D4 390 6,46750
A0A649VJJ3 390 6,15887
A0A649VKX6 390 6,15887
A0A7L7SK57 390 6,15887
A0A7U0J5X7 390 6,46739
E0YPF8 390 6,46739
H6U5F7 390 6,15887
A0AAE7VHZ0 390 5,50045
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_27600
5Jhdd
 38 31,1% 1411 5.313E-193
2 phalp2_12304
7qhxR
 109 23,5% 1488 3.497E-53

Domains

Domains [InterPro]

No domain annotations available.

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage UPIE
[NCBI] 		1034147 Vilmaviridae > Bronvirus > Mycobacterium virus Bron
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
JF704113 [NCBI]
CDS location
range 24373 -> 25545
strand +
CDS
TTGGCGCTACTGGGAAGCCTTACGGCTGATTCGTCTTTTGACGATGTTGGGGAAGCGATTGTTAGGGAATGTCTAAGGCGCGGTTATCCGCCGACTAAGACCATTGCGTGTGTCTCGACTGCGATTCAGGAGTCCTACCTCAGGCCGCGCGCGAGAAGCGCTAACGGCCTGTGGGTAGGCATTTACCAGCAGGACACGAGTTATCCAAAGCGGGAGGACCCGAACGAAAACATTCGGGAGTTCCTGAACCGGCTGGATGTTAAATGCGCGAGCGCGGGTGCGTCTCCGGACCCGTGGAAAAACATCTTCTGGCTTCAGCAGAGGCCAGGGGAGAAGTCCGCTGAGGACGCGTACCGCAATGGTCGCCAGGCGTACCTAACCGAGATTAAGAGTCGCGTTAATCAGGCGACGGTTTTATTTGAGAAGTATTCGGGGGGTGAGGTAATCGTGGCCGAACGGCCAGACTTTAACGAGTACGCGATTTGGAGTCCTAACCGCTCTTCACGCAACGGTGTTAAACCGACCATGTTCCTTCTCCATACGCAGGAGGGGAACGGCAATGCGGATTCGTTGGCGAAGTATTTCACGTCCGCGAATCAGGTTAGTTACCACTACACGATTTCTAAGGGCGCTAACGACGATGGGGTGACTGTCGTCGACTGTGTTGATACGGATTACGCGGCGTGGTCGGTGGGTAACGCGAATAGCCGGTCGATCAACCTGTGCTTTGCGGGTTCGTTCGCGTCGTGGACGCGTGAGCAGTGGTTGGCTAAGGCTGGCCGCGCTATCGACGTGGCCGCGTATCTGGCGGTGCAGGACGCTAAGAAGTACGGGTTTTCGACGCTGGTGGTGCCGCCGCCGTACTCGAATGGCACGCCGGGTATCAGCGATCACCGTTGGGTCACGGACGTGTTCAAGTGGGGCACCCATACGGACGTTGGTCCAGGGTTCCCGTGGGACGTGCTAGCGGCCTCTGTGGCGAAGTACACGGGCCAGGCGCAGGCCCCGGCAGCACCGTCGTTCGCCTACCCGTCCACGGACGTAATGATCCGCGAGATTTGGGAACAGTTGCGCGGCCCGCAGGGTAAGGGTTGGCCGCAGCTTGGTAAGAACGCTAAGGGCGAGAACTTGACCCTTGTCGACGCCATCGCCGAACTGAAAGCGGCGAGCTAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000218d92e_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (728Ni) rather than this protein.
PDB ID
728Ni
Method AlphaFoldv2
Resolution 62.84
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50