Protein

Protein accession
B4XYQ9 [UniProt]
Representative
71T7l
Source
UniProt (cluster: phalp2_32213)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKFKTKLITLVVAFLAAISFSLPSQVNAAKGDQGVDWSRYQGDNGVFGYSTDKFGISQIGGYSGYGTYEQTTYKTQVASLIAAGKRAHTYIWWQNIDNTNLAKQVLDHFLPEIQTPKGSIVALDYEAGSTNTATLLWALDYIRDAGYTPMLYGYKSFLVNHINLSQIASRYQLWLAEYPDYNVTTVPNYNYFPSFDNVGIFQFTSTYRAGGLDGNVDLTGITDSGYNGSTTTGSGKTYVKPATSTPATKAGQQANNTTLSQIKAGDNVKVNFGTTRWANGVAMPSWVQGKTYTVQQVSGSNVLLGGIMSWINRSNVELLTTTSVPSVSYGSTYTVQSGDSWWSIAYKYGMSMYTLASNNGKSIYSVIHPGDVLRVSGGYSVAVSSHTYYTVRYGDSFWSIASKYGISMYTLAANNGKSIYSLIYPGESLYIR
Physico‐chemical
properties
protein length:432 AA
molecular weight:47272,3 Da
isoelectric point:8,99
hydropathy:-0,19
Representative Protein Details
Accession
71T7l
Protein name
71T7l
Sequence length
615 AA
Molecular weight
68889,25470 Da
Isoelectric point
4,90341
Sequence
MVKWQATLSTTEPYNYIGIQNVRQGNRNTEVLEAILVENALPLDLTGCEVFFESVIDNKYPIQRSAKIVNAKKGIIQYTFDEYSMQSLHRQEAYFSIHKGDNLIGATQNFSYFVVNAASKTEGEMGSYWQSIEDLIADMTAFINENKGDFTAWMNARKEEFEKWRKARNRLSKWFESIKDILKTVDPGGTMLAELMDARVDIQGVRHNSISERLLADMEYLYQFAAKGDQGVDLSIWNGYQATFGYAHDKFSISQIGGQNNYGIYDQVTYSSQVASTIAQGKRAHTYVWWQNVLTYENAKQVLDYFLPKVQTPKGSIVALDAEDGVQSTDVTLWALDYIKEAGYTPMLYGYKGYLTSSYDLSRIAKKYQLWMAEYPDYEVTPYPNYNYFPSFENIGIFQFTSTYVAGGLDGNVDLTGITDNGYTKNNQPATNTPAIEEGKEVENTPSSDVKVGDTVKVKFSVDAWATGEAIPQWVKGNSYKVQEVTESRVLLEGILSWISKGDIELLPDAATVPDKQPEATHVVQYGETLSSIAYQYGTNYQRLAALNGLTNPNLIYPGQILKVNGSVVSNIYTVQYGDNLSSIAAKLGTTYQTLAALNGLANPNLIYSGQTLSY
Other Proteins in cluster: phalp2_32213
Total (incl. this protein): 9 Avg length: 465,4 Avg pI: 8,34
Protein ID Length (AA) pI
71T7l 615 4,90341
A0A3G3LKJ1 432 8,98362
C1KFN7 491 9,25465
A8YQK7 432 9,07059
A0A6M3BF05 432 6,89886
A0A7G9V4R6 491 9,00973
A0A8S5UYQ0 432 8,98356
A0AAF0APU0 432 8,98356
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_21701
3ifCN
 920 63,9% 394 1.495E-180
2 phalp2_17635
6JmE3
 482 28,2% 407 1.104E-29

Domains

Domains [InterPro]
BppU_N
Unannotated
GH25
Unannotated
LysM
LysM
Representative sequence (used for alignment): 71T7l (615 AA)
Member sequence: B4XYQ9 (432 AA)
1 615 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01476, PF10651

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage Lrm1
[NCBI] 		496874 Larmunavirus > Larmunavirus Lrm1
Host Lactobacillus rhamnosus
[NCBI] 		47715 Firmicutes > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
EU246945 [NCBI]
CDS location
range 19539 -> 20837
strand +
CDS
ATGAAATTTAAAACTAAACTGATTACTTTGGTAGTCGCCTTCTTGGCGGCTATTTCTTTTTCCCTGCCATCGCAGGTGAATGCGGCCAAGGGAGATCAGGGTGTCGACTGGAGCCGGTACCAAGGAGATAACGGTGTCTTTGGTTATTCCACTGACAAGTTCGGCATCTCTCAAATTGGTGGATACAGTGGATACGGCACGTACGAGCAAACCACCTACAAGACACAGGTTGCATCGTTGATTGCGGCTGGTAAGCGGGCACACACCTATATCTGGTGGCAGAATATCGACAACACCAATTTGGCCAAGCAAGTACTAGATCATTTCTTGCCTGAGATTCAAACACCAAAAGGGTCGATTGTTGCGCTTGACTATGAGGCCGGATCAACCAACACGGCAACCTTGCTGTGGGCACTCGACTATATCCGCGATGCTGGGTACACGCCAATGCTCTACGGTTATAAGAGCTTCTTGGTTAACCACATCAACTTGTCACAGATTGCCAGCCGCTATCAGTTATGGCTCGCGGAATATCCTGATTACAATGTCACTACCGTACCGAATTACAATTATTTCCCTAGTTTTGACAATGTAGGTATCTTCCAGTTCACTTCAACTTATCGCGCTGGCGGCCTTGATGGTAACGTTGATCTAACTGGCATCACTGATTCAGGCTACAACGGTAGCACGACAACGGGTAGTGGTAAAACTTATGTTAAGCCTGCTACGAGCACACCAGCGACAAAAGCAGGCCAGCAAGCCAACAACACCACACTTAGCCAGATCAAAGCTGGCGATAATGTTAAGGTTAACTTCGGCACAACCCGTTGGGCTAATGGTGTCGCAATGCCTAGCTGGGTTCAGGGCAAGACGTACACTGTTCAGCAAGTATCCGGATCTAACGTATTGCTTGGTGGCATCATGAGCTGGATCAATCGTAGCAATGTTGAGCTGTTGACAACGACCAGCGTGCCGTCAGTAAGCTATGGCTCTACCTACACGGTTCAGTCTGGTGACAGTTGGTGGTCGATTGCTTACAAATATGGCATGAGCATGTATACTTTGGCTTCTAACAACGGTAAGTCAATCTACAGTGTGATTCACCCAGGCGATGTATTGCGTGTCTCTGGTGGCTATTCAGTGGCCGTATCAAGTCACACGTACTACACGGTTCGATATGGTGACAGCTTCTGGAGCATTGCCAGCAAGTATGGCATTAGCATGTACACGTTAGCCGCTAACAATGGCAAGTCAATCTACAGCTTGATCTATCCGGGCGAAAGCCTGTATATCAGGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi00017bab1a_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (71T7l) rather than this protein.
PDB ID
71T7l
Method AlphaFoldv2
Resolution 80.70
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50