Protein

Protein accession
A7TWR7 [UniProt]
Representative
7kL3N
Source
UniProt (cluster: phalp2_27772)
Protein name
Amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKTYSEARARLRWYQGRYIDFDGWYGYQCADLAVDYIYWLLEIRMWGNAKDAINNDFKNMATVYENTPSFVPQIGDVAVFTKGIYKQYGHIGLVFNGGNTNQFLILEQNYDGNANTPAKLRWDNYYGCTHFIRPKYKSEGLMNKITNKVKPPAQKAVGKSASKITVGSKAPYNLKWSKGAYFNAKIDGLGATSATRYGDNRTNYRFDVGQAVYAPGTLIYVFEIIDGWCRIYWNNHNEWIWHERLIVKEVF
Physico‐chemical
properties
protein length:251 AA
molecular weight:29057,6 Da
isoelectric point:9,25
hydropathy:-0,48
Representative Protein Details
Accession
7kL3N
Protein name
7kL3N
Sequence length
163 AA
Molecular weight
18993,33920 Da
Isoelectric point
9,20894
Sequence
MKTYSEARARLRWYQGRYIDFDGWYGYQCADLAVDYIYWLLEIRMWGNAKDAINNDFKNMATVYENTPSFVPQIGDVAVFTKGIYKQYGHIGLVFNGGNTNQFLILEQNYDGNANTPAKLRWDNYYGCTHFIRPKYKSEGLMNKITNKVKPPAQKQSVNLQVK
Other Proteins in cluster: phalp2_27772
Total (incl. this protein): 52 Avg length: 234,4 Avg pI: 8,96
Protein ID Length (AA) pI
7kL3N 163 9,20894
1M1vw 130 7,76514
5BAgk 132 5,05511
78p7A 206 8,88486
7vBUN 188 9,59730
7vBUS 184 9,35889
7vBVR 163 9,04184
7vypd 143 7,85169
7wA74 170 9,05273
7wA8o 163 7,85600
E0Y3N1 251 9,25200
A0A223LH90 251 8,77281
A0A075LZV3 257 9,25200
A0A6M9Z395 251 8,77281
Q4ZCZ2 251 9,25200
A0A499SSS7 251 9,23131
A0A0H3U325 251 9,25200
A0A1J0MF80 251 8,77281
A0A1J0MF88 251 8,77281
A0A1J0MG26 251 8,77281
A0A1P8L6B2 251 9,25200
A0A1W6JPQ5 251 9,25200
A0A1W6JQ85 251 9,25200
A0A1X9H021 251 9,25200
A0A1X9H092 251 9,25200
A0A223LFP9 251 8,77281
A0A223LGK1 251 8,77281
A0A223LGS5 251 8,77281
A0A345AQ64 251 9,25200
A0A345AQJ1 251 9,25200
A0A345AQQ9 251 9,25200
A0A345AR29 251 9,25200
A0A385IRL8 251 9,25200
A0A494W9E6 251 8,77281
A0A494W9Q0 251 9,12913
A0A494WD81 251 8,91432
A0A499SIE6 251 8,92483
A0A513ZXN3 251 9,25200
A0A513ZXT8 251 9,25200
A0A5B8RNT3 251 8,77281
A0A6M9Z3L4 251 8,77281
A0EX11 251 9,25200
C8CH38 251 9,25200
D2JLG5 251 9,25200
Q4ZE09 251 9,25200
Q8SDJ9 251 9,25200
Q9MBN4 251 9,24098
R9QSV2 251 9,25200
A0A9E7QR95 251 9,31228
A0AAX3C8V3 251 9,25200
A0AB39C7Y7 251 9,03687
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_13870
7vCZb
 24 39,2% 140 2.478E-44
2 phalp2_796
28Kwv
 80 49,3% 160 1.354E-41
3 phalp2_368
7aJP9
 3 40,8% 142 1.528E-39
4 phalp2_25333
7ocj2
 56 37,5% 149 4.143E-30
5 phalp2_39580
6iLgH
 177 37,0% 151 3.764E-26
6 phalp2_24452
4BMZo
 66 33,0% 133 2.463E-22
7 phalp2_3543
4zM0o
 163 27,3% 139 2.953E-18
8 phalp2_30026
2tAM9
 32 30,2% 139 1.031E-17
9 phalp2_568
Omza
 65 31,8% 138 1.925E-17
10 phalp2_17703
71dZW
 23 32,0% 125 1.925E-17

Domains

Domains [InterPro]
CHAP
Disordered region
Representative sequence (used for alignment): 7kL3N (163 AA)
Member sequence: A7TWR7 (251 AA)
1 163 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF05257

Taxonomy

  Name Taxonomy ID Lineage
Phage Staphylococcus phage tp310-3
[NCBI] 		445517 Peeveelvirus >
Host Staphylococcus aureus
[NCBI] 		1280 Firmicutes > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
EF462199 [NCBI]
CDS location
range 37605 -> 38360
strand +
CDS
ATGAAAACATACAGTGAAGCAAGAGCAAGGTTACGTTGGTATCAAGGTAGATATATTGATTTTGACGGTTGGTATGGTTACCAATGTGCAGATTTAGCAGTTGATTACATTTATTGGTTGTTAGAAATTAGAATGTGGGGAAATGCAAAAGATGCAATCAATAACGATTTTAAAAACATGGCAACAGTATATGAAAACACACCATCGTTTGTTCCACAAATAGGTGATGTGGCTGTATTTACCAAAGGAATATATAAACAATACGGTCATATTGGTTTAGTGTTTAATGGTGGTAATACAAATCAATTTTTAATTTTGGAACAGAACTATGACGGTAACGCAAATACGCCTGCAAAGTTACGTTGGGATAATTATTACGGCTGTACTCACTTTATTAGACCTAAGTATAAAAGTGAGGGCTTAATGAATAAGATCACAAATAAAGTTAAACCACCTGCTCAAAAAGCAGTCGGTAAATCTGCAAGTAAAATAACAGTTGGAAGTAAAGCGCCTTATAACCTTAAATGGTCAAAAGGTGCTTATTTTAATGCGAAAATCGACGGCTTAGGTGCTACTTCAGCCACTAGATACGGTGATAATCGTACTAACTATAGATTCGATGTTGGACAGGCTGTATACGCGCCTGGAACATTAATATATGTGTTTGAAATTATAGATGGTTGGTGTCGCATTTATTGGAACAATCATAATGAGTGGATATGGCATGAGAGATTGATTGTGAAAGAAGTGTTTTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
A0A0H3U325
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A1P8L6B2
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A1W6JPQ5
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A1W6JQ85
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A1X9H021
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50

Showing first 5 of 25 structures.

The structures below correspond to the cluster representative (7kL3N) rather than this protein.
PDB ID
7kL3N
Method AlphaFoldv2
Resolution 89.75
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50