Protein

Protein accession
A0A7T7ZAG9 [UniProt]
Representative
2mvmf
Source
UniProt (cluster: phalp2_4390)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSKKGIDVSEWQGDIDFNAVKASGVEFVIIRAGYGIGCKDKWFEQNYRKAKAAGLDVGAYWYSYANSGFEAAEEAQSCVNMLSGKSFEYPVYFDLEEKSQLNRGRAFCDSLITSFCNKLEACGYYAGFYTSLSTANNLVSAHVRDRYALWIAQWNTHCNYQGSYGLWQYSSSGSVPGVAGRVDMDYAYVDYPSIIKNAGLNGCKNGGSDQAARTSSIDEVAREVINGAWGNGNERKQRLTQAGYDYASVQNKVNELLGVKACRKSVDELAREVIRGTWGNGNERKNRLTQAGYDYDTVQKRVNELL
Physico‐chemical
properties
protein length:306 AA
molecular weight:34025,4 Da
isoelectric point:6,74
hydropathy:-0,51
Representative Protein Details
Accession
2mvmf
Protein name
2mvmf
Sequence length
145 AA
Molecular weight
16014,91730 Da
Isoelectric point
8,66824
Sequence
MAIKGIDVSVWQGNIDFGKVKVSGINFVIIRAGYGNGNKDKWFDENYRKAKAAGLHIGAYWYSYATSADGAKQEAQSCAKVLSGKQLDYPVYFDIEEKSQLSRGKDFCSSLITAFCTELERLGYYAGFYTSLSSLNSVISDAVKK
Other Proteins in cluster: phalp2_4390
Total (incl. this protein): 118 Avg length: 205,6 Avg pI: 6,84
Protein ID Length (AA) pI
2mvmf 145 8,66824
1f96G 194 4,05003
1jFSi 155 6,71066
1jT7v 199 7,58161
23JaM 171 8,43403
23iUj 144 4,94820
2Ai6 123 8,41959
30EXK 187 8,84663
3LP3E 132 6,13187
3TQ6u 122 4,72726
3VFxB 157 5,12565
3VHxc 153 6,10146
3VLVA 317 8,80369
3WFd7 156 5,54336
3k3ye 111 5,81539
3kpQc 267 7,78380
3kri7 144 8,95764
3l2Jb 272 9,73732
3lKTk 132 6,57681
3mawn 132 5,03721
3mhY6 235 6,83963
3onR2 265 6,91562
3sQPq 189 4,14211
3tAzL 167 8,16294
3tn8E 197 5,41502
3tsgg 127 9,16220
3txxu 143 5,75122
3tyke 155 9,01805
3u3R7 267 5,76253
3uRMK 286 8,30445
3uiWF 173 9,08535
3v0eM 285 8,49476
3vOk8 134 8,83567
3wrmh 111 5,81539
3xQWx 134 9,06227
3xXtz 111 6,56709
3yrjo 263 7,74536
40CBw 258 8,81239
4LaQ0 241 5,06870
4MiOY 124 4,81616
4yy9u 262 8,72065
5HJ71 189 4,11932
5HJXK 191 4,05003
5JYYE 187 5,16805
5KxRM 261 5,64703
5Mrcm 188 4,23316
5Nc7t 281 7,02191
5ONoV 262 5,87104
5PTbK 281 7,76940
5QoLo 261 5,86967
5QzJT 260 5,53904
5RoHN 281 8,49476
5U5dL 211 5,61611
5ULOd 261 5,76975
5UuLf 261 6,08259
5VcAZ 126 4,05003
5VqSh 262 5,57587
5WXKY 262 5,97482
5ZpbJ 119 4,72135
5ou7C 141 4,26045
5tD8T 200 8,87428
614h2 232 8,57534
61x35 261 5,29315
62Kyn 267 6,66672
62U9X 160 8,33101
63JjM 262 6,97155
68P2v 147 9,03758
69Ema 191 5,59349
69Tg6 188 5,94351
6ZfgM 178 9,47113
6bl0t 261 5,87069
6bmrE 262 6,30898
6eFBr 265 6,91562
6ejK2 157 4,61194
6eprB 168 8,67753
6fflD 261 5,97619
6g6p6 185 5,25331
6gcsC 237 8,56690
6hByR 142 9,23589
6hXKt 220 5,55058
6jmGF 195 9,04287
6kK7S 262 7,02129
6lRQX 125 8,48773
6mB5E 171 4,16678
6nFRu 281 8,49476
6nXMa 186 6,29164
6njwe 233 6,74062
6npmi 272 9,72533
6oEFS 261 5,69455
6oPLg 262 5,69836
6os3v 262 6,07657
6pddW 188 5,49243
6qF8d 153 9,04209
6r7gT 258 6,53151
6sehV 258 8,93585
6tJN7 262 5,88201
6uWCX 261 5,69626
6vSMk 265 5,98398
76tpy 146 9,41988
7MsbT 267 6,16938
7Nq5t 155 7,75292
7UICd 269 5,12855
7Y6Ym 111 5,81539
7sAQi 171 4,08322
8g4zl 138 9,44747
8jHYn 266 6,97007
8jT4j 158 8,63040
8klFt 285 8,92483
F688 271 9,73732
NPrl 144 6,90761
NU3H 128 4,97156
mYma 118 8,64394
oePX 222 5,20778
oqdn 315 8,06198
osqO 150 5,73604
ww70 152 6,71663
xs8w 263 8,62975
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_14273
3kLGA
 7 40,7% 140 1.029E-43
2 phalp2_24879
a1g4
 16 43,5% 131 1.604E-41
3 phalp2_10753
3yWC4
 1 33,8% 139 1.329E-39
4 phalp2_5668
4yhqW
 7 40,9% 144 4.274E-38
5 phalp2_11218
6q99m
 1 34,7% 141 1.101E-37
6 phalp2_25924
66tGM
 6 53,5% 99 1.374E-36
7 phalp2_29946
8mgNr
 1 41,4% 135 1.883E-36
8 phalp2_3380
3qQTc
 8 44,8% 98 4.851E-36
9 phalp2_5939
6bh0H
 94 35,9% 142 2.928E-34
10 phalp2_34287
3mtX2
 6 44,2% 95 6.231E-32

Domains

Domains [InterPro]
GH25
Representative sequence (used for alignment): 2mvmf (145 AA)
Member sequence: A0A7T7ZAG9 (306 AA)
1 145 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Gardnerella phage vB_Gva_AB1
[NCBI] 		2800706 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MW387018 [NCBI]
CDS location
range 33618 -> 34538
strand +
CDS
ATGAGTAAAAAAGGAATAGACGTGTCAGAGTGGCAGGGTGACATTGATTTCAACGCGGTGAAAGCATCCGGTGTTGAGTTTGTGATCATTCGAGCAGGATACGGTATCGGATGCAAAGACAAGTGGTTTGAACAGAACTATCGTAAAGCAAAAGCAGCTGGTCTTGATGTTGGAGCCTACTGGTATTCGTACGCAAACTCTGGTTTTGAGGCGGCTGAGGAGGCTCAAAGCTGTGTGAACATGCTTTCAGGTAAGAGTTTTGAGTATCCTGTTTACTTTGATTTGGAAGAGAAAAGCCAGCTTAACCGTGGGCGAGCTTTCTGCGATTCGCTGATTACAAGCTTTTGCAATAAGCTGGAAGCTTGCGGGTATTATGCAGGTTTTTACACTTCGCTTTCAACTGCTAATAATCTTGTGTCCGCTCATGTTAGAGACCGTTACGCTTTGTGGATCGCACAGTGGAACACGCACTGCAATTATCAGGGTTCGTATGGTCTTTGGCAATACTCGTCAAGTGGCAGTGTGCCTGGAGTAGCCGGCAGAGTTGACATGGATTATGCTTACGTGGATTATCCGAGCATTATTAAAAACGCTGGATTAAACGGGTGTAAAAACGGCGGCTCTGACCAAGCTGCGCGCACGTCAAGTATTGATGAGGTGGCGCGAGAAGTTATTAACGGCGCTTGGGGTAACGGAAATGAGCGTAAACAGCGTTTAACTCAAGCCGGATACGATTATGCGAGCGTGCAAAATAAGGTTAATGAGCTTCTCGGTGTTAAAGCCTGTAGAAAGTCGGTTGATGAGCTTGCGCGTGAAGTAATCCGAGGCACGTGGGGTAACGGAAATGAGCGTAAAAACCGTTTAACTCAAGCCGGATACGATTATGATACGGTACAAAAACGAGTAAACGAACTCTTGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
A0A7T7ZAG9
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (2mvmf) rather than this protein.
PDB ID
2mvmf
Method AlphaFoldv2
Resolution 96.65
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50