Protein

Protein accession
A0A7T3KC70 [UniProt]
Representative
8MElA
Source
UniProt (cluster: phalp2_32347)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MATGFYLLDNPQPHTQQWGYPRRGAKLTGTCIIHTAECAIDYEGADTAAEGTAVFIRNRSDYGSYHDLVDSDSIIEMVPFEYEAWQDSETNPWAVGISAAVTANDWLTIPVARRNKIYRNMAWCAADFVKYMKEAYNITVPLRRITGAQARAGVPGFCAHGDSGISRYDPGPDFDWALFFRYTQEALNGTVAAQASATAKKELDVAPKWKRMISKPADRRLAKGLEWYLKDASGKINENYASLGAGSYDIDLFIQGNGLFDGESIQVQFYLVNTKNGKREASGYFPQEVHGSTDGVFKASVRFKMPVAGKRLEVGVMSTSETAHLKVYGADVYNLG
Physico‐chemical
properties
protein length:336 AA
molecular weight:37156,3 Da
isoelectric point:6,11
hydropathy:-0,35
Representative Protein Details
Accession
8MElA
Protein name
8MElA
Sequence length
333 AA
Molecular weight
36383,30290 Da
Isoelectric point
7,66277
Sequence
MTTGYLLVDQPNPTTPQGTFPRRGTRGKLTGTCIVHTSEGAWQAGVDSLTNQVRTRTDYGCYHRACDWQDIALYYPWEWEAWQDSETNNWAVGIAAACRTSDWAIMPADIREGFYRNMARMAADFVTYMKAEHGITVPLVRLSGEQARAGVPGFCAHGDSGISRTDPGADFNWTLFFTYTRQALAGITAQGGTTAPVKKESEMPTSKRVDSAFKARHRLPKGKAYTLSVKDDGGSANFAVNGAGHYLIHNHIRGEGLLPGQRIKAQFFITKGGKTSGHFAQDIVGTIDGTFDQPVEFNRAVETGTTLTCLLTSSNTETAYITGFGAEVTTWKA
Other Proteins in cluster: phalp2_32347
Total (incl. this protein): 7 Avg length: 304,0 Avg pI: 6,18
Protein ID Length (AA) pI
8MElA 333 7,66277
42xoE 334 6,54310
A0A3G2KER3 333 7,66277
A0A0U4B3G8 270 5,14850
A0A249XPR0 261 5,10172
A0A9E7MN79 261 5,03886
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_36881
7s6K6
 44 42,2% 218 3.287E-56
2 phalp2_31913
4N8u3
 4 32,9% 237 3.560E-47
3 phalp2_22788
7oqUg
 6 36,4% 203 5.410E-37
4 phalp2_21748
3Ptm0
 18 30,1% 318 1.794E-32
5 phalp2_9231
6Te1j
 3 30,1% 222 4.482E-32
6 phalp2_7699
6IwWh
 11 29,5% 227 8.352E-21
7 phalp2_24092
8fabO
 1 26,8% 242 9.034E-11
8 phalp2_24741
6EXtT
 52 22,7% 215 1.204E-10
9 phalp2_36735
6wX8V
 3 24,2% 219 3.640E-08
10 phalp2_32423
SnuP
 3 20,5% 224 1.337E-04

Domains

Domains [InterPro]
Unannotated
Unannotated
Representative sequence (used for alignment): 8MElA (333 AA)
Member sequence: A0A7T3KC70 (336 AA)
1 333 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Arthrobacter phage Wollypog
[NCBI] 		2790985 Wollypogvirus > Wollypogvirus wollypog
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MW055913 [NCBI]
CDS location
range 21256 -> 22266
strand +
CDS
ATGGCTACAGGATTCTATCTGCTAGACAACCCACAGCCTCATACACAACAGTGGGGCTATCCGCGCCGAGGGGCCAAGCTCACCGGCACATGCATCATCCATACCGCTGAGTGTGCCATCGACTATGAAGGGGCTGACACTGCGGCCGAGGGCACAGCGGTGTTCATCCGCAACCGCTCAGACTATGGCTCCTATCACGACCTGGTGGACAGCGACTCCATTATCGAGATGGTTCCGTTCGAGTATGAGGCGTGGCAGGACTCCGAAACCAACCCATGGGCTGTGGGCATCTCTGCCGCAGTCACGGCCAACGACTGGCTCACGATCCCCGTCGCTCGTCGAAACAAGATCTATCGCAACATGGCATGGTGTGCAGCTGACTTTGTGAAGTACATGAAGGAAGCGTACAACATCACGGTGCCCTTGCGCAGGATCACTGGGGCGCAGGCTCGTGCAGGCGTTCCCGGCTTCTGCGCCCATGGAGACTCGGGGATCAGCCGGTACGATCCCGGTCCCGATTTCGACTGGGCGCTGTTCTTCCGGTACACCCAGGAAGCGCTCAATGGAACGGTAGCAGCACAAGCATCAGCAACAGCAAAGAAGGAGCTCGACGTGGCACCCAAGTGGAAGCGCATGATCAGCAAGCCGGCAGACCGGCGTCTGGCCAAGGGTCTGGAATGGTATCTGAAGGACGCGAGCGGAAAGATCAACGAGAACTATGCGTCGCTCGGCGCAGGCTCGTACGACATCGATCTGTTCATCCAGGGCAACGGATTGTTCGACGGCGAGTCCATCCAGGTCCAGTTCTACCTCGTGAACACCAAGAATGGTAAGCGCGAGGCTTCCGGGTACTTCCCGCAGGAGGTGCACGGATCCACGGACGGCGTGTTCAAGGCGAGCGTTCGCTTCAAGATGCCCGTCGCGGGTAAGCGGCTCGAGGTAGGTGTAATGTCCACGAGCGAAACCGCCCATCTCAAGGTTTACGGCGCGGACGTCTACAATCTCGGCTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8MElA) rather than this protein.
PDB ID
8MElA
Method AlphaFoldv2
Resolution 87.66
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50