Protein

Protein accession
A0A7S5Y8W0 [UniProt]
Representative
25Cxw
Source
UniProt (cluster: phalp2_6734)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 95% (predicted by ML model)
Protein sequence
MDNTLGDIRNHEHMSVVAERIKDDEGKRNIPYQLEYKGNMKNKVKEDFYTVGYGHKIYGEVKEFYSNDEIEALFEQDFKKAQDGALRLLDGAVIKPEAFGVLTEMVYQMGEKGVGGFKKTLDFLKEGNYKEAGLEVLKGNSAGTVSNWSLQTPKRADRASKLLISLSK
Physico‐chemical
properties
protein length:168 AA
molecular weight:18962,3 Da
isoelectric point:6,33
hydropathy:-0,65
Representative Protein Details
Accession
25Cxw
Protein name
25Cxw
Sequence length
202 AA
Molecular weight
22845,88090 Da
Isoelectric point
6,92455
Sequence
LRKADKGLVSEALAQAYFARDPNLIVFTALGGVGPVDICTYNIKTKEYCNYDVKTVSYRKSNTKYGHKNNDRINILAKVYLDSLGKATIGYGHLLTEEDDFVEGVIYDKDILEALFEKDFNKAVQGAEELLKGYNIALVAKEVIIEMVFQLGKTGVSKFKKMFDALKNNEYSKAADEMLNSAWYRQTPSRCEELSNLMRSCY
Other Proteins in cluster: phalp2_6734
Total (incl. this protein): 80 Avg length: 157,9 Avg pI: 5,49
Protein ID Length (AA) pI
25Cxw 202 6,92455
1B0nn 143 5,10127
1JJmS 144 5,26087
1JT0F 142 5,28991
1O9mE 144 5,00271
1Qbr8 143 5,47225
1RyFH 246 7,17083
1UHj2 246 7,16986
1Uee 143 4,72817
1imWC 143 6,14841
1sfJM 143 4,58380
1wst5 251 6,59863
1xGWz 245 8,87789
27WZm 142 5,41973
27vdE 142 5,28105
286Q8 144 5,13685
287qA 142 5,27815
2MlF1 143 4,58380
2cUrV 142 5,24387
2iFE1 144 5,42968
2iFGi 142 5,61452
2jz2l 142 5,24666
2kY7b 142 5,24666
2yY7i 239 5,14236
38e3O 144 4,98821
38eVG 144 5,10865
3D1V8 244 8,72678
3EaZL 245 8,99200
3IDte 143 4,99151
3VXaG 142 5,27815
3W6UU 142 5,26894
3XJFI 142 5,29770
3YDun 142 5,27815
3dqLk 143 4,91910
3rCl1 143 4,63462
41RKz 142 5,26894
42Qhc 244 5,44963
479KY 143 5,27462
4A9CY 142 5,45173
4NKol 142 5,27815
4Ze72 142 5,44383
4bGxP 142 5,25945
4sWOs 143 4,56738
4zWzG 142 5,25644
513s5 144 5,10865
55XvF 144 5,00271
5HWLZ 142 5,79078
5af1K 144 5,00271
5fXmQ 144 5,25649
5tsHD 144 5,23029
5urfO 142 5,26598
5ym1q 144 5,00271
6HG8a 144 5,26087
6LZZ2 142 5,42695
6Lskh 144 5,10865
6xP33 144 4,90341
7K9sp 144 5,00271
7Zk3t 142 5,42695
82O0d 246 7,04789
83cDL 142 5,28105
85Q2J 244 5,61805
8b5pZ 142 5,45173
8eOs4 142 5,27815
8hEGs 246 7,04789
8jEyz 142 5,13008
8jrfF 142 5,42695
8m0TW 144 5,03050
8sNHX 142 5,45173
CaJD 142 5,45935
GOyq 142 5,55331
H0mw 142 5,16072
HjLh 142 5,28991
IDfX 142 5,41706
KS1Y 142 5,04249
e0zP 143 4,65150
jLd1 144 5,44088
jVpc 142 5,27815
x4lC 142 5,00271
A0A4Y1NTQ2 143 4,58380
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_21661
31ima
 875 57,3% 129 5.271E-51
2 phalp2_27968
RI1z
 5083 45,6% 125 9.787E-33
3 phalp2_2924
QDRo
 8927 35,7% 137 8.498E-29
4 phalp2_33457
7eghX
 14 41,2% 126 7.563E-28
5 phalp2_30730
7scFT
 23 38,7% 124 1.520E-25
6 phalp2_19234
42usC
 219 31,4% 140 1.837E-24
7 phalp2_24334
3Qw2p
 463 39,5% 139 1.189E-23
8 phalp2_35661
1vtav
 97 30,7% 140 4.128E-23
9 phalp2_17008
8jNgs
 3526 40,4% 126 7.688E-23
10 phalp2_9780
80F6A
 154 31,2% 144 1.260E-21

Domains

Domains [InterPro]
Unannotated
GH24
Representative sequence (used for alignment): 25Cxw (202 AA)
Member sequence: A0A7S5Y8W0 (168 AA)
1 202 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pelagibacter phage Eistla EXVC025P
[NCBI] 		2736226 Autographiviridae > Pelagivirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MT375521 [NCBI]
CDS location
range 6784 -> 7290
strand +
CDS
ATGGATAATACATTAGGTGATATTAGAAACCATGAACATATGAGTGTTGTGGCAGAGCGTATTAAAGATGATGAAGGTAAGAGAAATATACCTTATCAACTAGAATACAAAGGCAACATGAAAAATAAAGTAAAAGAAGACTTTTATACCGTAGGATATGGACATAAAATATATGGTGAAGTAAAAGAATTTTACAGTAATGATGAAATAGAAGCTTTATTTGAACAAGATTTTAAGAAAGCTCAAGACGGTGCTTTAAGATTACTTGATGGTGCTGTTATAAAACCTGAAGCTTTTGGTGTTTTAACTGAAATGGTGTATCAAATGGGTGAAAAAGGTGTAGGTGGTTTTAAGAAAACATTAGATTTTTTAAAAGAAGGTAATTATAAAGAAGCAGGTTTAGAGGTTCTTAAAGGAAACTCTGCGGGAACTGTAAGTAATTGGTCTTTACAAACTCCTAAGAGAGCTGATAGAGCATCTAAGTTACTAATAAGTCTTAGTAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (25Cxw) rather than this protein.
PDB ID
25Cxw
Method AlphaFoldv2
Resolution 76.65
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50