Protein

Protein accession
A0A7S5PMJ4 [UniProt]
Representative
1pDJr
Source
UniProt (cluster: phalp2_20036)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MQLSRKGLEAIKFFEGLKLEAYEDSAGIPTIGYGTIRIGGKPVKMGMKITAEQAEQYLLADVEKFVAAVNKAIKIPTSQNEFDALVSETYNIGITAMQDSTFIKRHNAGNKVGCAEAMQWWNKVTVKGQKVTSNGLKNRRRMEADIYLDSVYPK
Physico‐chemical
properties
protein length:154 AA
molecular weight:17124,6 Da
isoelectric point:9,25
hydropathy:-0,34
Representative Protein Details
Accession
1pDJr
Protein name
1pDJr
Sequence length
408 AA
Molecular weight
43416,77080 Da
Isoelectric point
5,01550
Sequence
MRISPEGLTLIKRFEGLRLHAYQDVGGVWTIGYGTTRTPDGPVAEGQRITQTEAEAFLADDVREFEQGVDAAVTVGVTQPMFDALVSLAYNVGLGAFRGSTLLRKLNARDWEGAAAEFARWNKVGQTVVDGLTRRRAEEAAVFRAGVAQLTMQPAGPAPAAQPTASAPVAEAPAPAAPAPPPPYIDPMRSPEEARADEAWVRIERERLEAASIAATDTPGGPTMPLPVSAVVALGGELLKLLPFAAKPQQQDKLDTLAQQLVRIAQAVQPASVNEQQAVEQVRANPQLQRAFVAEAASQWSELQPLLEFEAGEREKARGFVEALTSGDAPMWRQIGAAGIVGVLSLLLIGGGGWIFYTMLIGDALDAGQKGMVLGALLAAFSGAVSFWFGSSASSQRKDRTIEEQARK
Other Proteins in cluster: phalp2_20036
Total (incl. this protein): 122 Avg length: 156,1 Avg pI: 9,18
Protein ID Length (AA) pI
1pDJr 408 5,01550
A0A384TAV0 154 8,88698
A0A6B9WWR1 154 8,57205
D2K0A1 154 9,07787
A0A1B1PD64 154 9,07787
A0A291AYS9 154 9,13893
A0A0K2CN83 154 9,27682
A0A0E3XCC0 154 9,23395
A0A142EZW8 159 9,40763
A0A2I6PH21 154 9,23395
K4I0N0 154 9,44721
A0A2I6PHR1 154 9,23395
A0A653FXZ4 154 9,36095
A0A7G3M9T8 154 8,92476
A0A291AXT8 154 9,16130
A0A0D4DAU1 154 9,23395
A0A0B5HA99 154 9,23395
A0A0K1LPG6 154 9,13867
A0A2K9V2F8 154 9,30010
K9K9S8 154 9,09715
A0A1V0DYV1 154 9,40673
A0A0N9SI93 154 9,36095
A0A0A0RKF2 154 9,25484
A0A0F6R666 154 8,88698
A0A0F6R9G3 154 8,88698
A0A0H3UCP7 154 9,23395
A0A1B1PDY4 154 9,23395
A0A1W6DWU5 154 9,23395
A0A2S1GPK4 154 9,07787
A0A384TDB0 154 9,46984
A0A385ISM9 154 9,36095
A0A411B9P2 154 9,49344
A0A411BH90 154 9,49344
A0A455XIZ2 154 9,23395
A0A481W2A3 154 9,23395
A0A482JGH9 154 9,51845
A0A482JKJ9 154 9,13893
A0A482JMB8 154 8,60700
A0A482MPW8 154 8,88698
A0A482MQH0 154 8,88698
A0A482MRY4 154 8,88698
A0A494RIC5 154 9,23395
A0A4Y5NXE2 154 9,09715
A0A4Y5NXT5 154 9,38307
A0A5B9MYH8 154 9,25458
A0A5Q2F7L2 154 9,23395
A0A653G1D6 154 9,36095
A0A653G7I6 154 9,36095
A0A679F8V0 154 8,88698
A0A6B9LPA3 154 9,23395
A0A6B9SP46 154 9,23395
A0A6B9WI36 154 9,36095
A0A6B9WIX5 154 9,09715
A0A6B9WN42 154 9,23395
A0A6B9WUX3 154 9,23395
A0A6B9WVD2 154 9,49344
A0A6B9WZ65 154 9,07787
A0A6B9X2R3 154 9,09734
A0A6B9X4V6 154 9,25458
A0A6B9XDI0 154 9,09734
A0A6B9XDL4 154 9,25458
A0A6B9XEY0 154 9,09715
A0A6B9XG93 154 9,23395
A0A6G5V611 154 9,21429
A0A6G6XZ82 154 9,07787
A0A7H0XB78 154 9,23395
A0A7S9SPQ4 154 9,07787
A0A7S9SPV2 154 9,07787
A0A7S9ST89 154 9,07787
A0A7U0J692 154 9,23395
K4I2W6 154 9,23395
K4I5A0 154 9,23395
S4TR07 154 9,25484
S4TSM1 154 9,25484
S4TV96 154 9,25484
S5M826 154 9,23395
A0A9E7A2T6 154 8,88698
A0A9E7LJI5 154 9,33974
A0AAE9WHV8 154 9,36095
A0AAE9WIE0 154 9,36095
A0AAE9WPB8 154 9,36095
A0AAF0B1K8 154 9,36095
A0AAF0B1P7 154 9,36095
A0A6G8QY11 154 9,23395
A0A6G8QZA5 154 9,23395
A0A6G9LTD3 154 9,38307
A0A6J5M6T5 147 9,40698
A0A7T5QU83 154 9,23402
A0A899IL77 154 8,55613
A0A8E7BYS6 154 9,23395
A0A8X8M8D9 154 9,32453
A0A8X8M8W0 154 9,54579
A0A8X8M9F5 154 9,27708
A0A976SGJ0 154 9,25490
A0A9E7N496 154 9,32453
A0A9E7TBH4 154 9,23395
A0AA47KZP6 154 9,23427
A0AA49EZD9 154 8,55607
A0AA51U6L9 154 9,27663
A0AA94WYN7 154 9,25484
A0AAD1V3P5 154 9,23395
A0AAE7J1C6 154 9,23395
A0AAE7SAX1 154 9,25458
A0AAE7V7E4 154 9,25458
A0AAE7V8D5 154 9,25458
A0AAE8XN56 154 9,23395
A0AAE8Y0N4 154 9,36095
A0AAE9CFF2 154 9,23395
A0AAE9CHW7 154 9,27682
A0AAE9HQF0 154 9,23395
A0AAE9HQH4 154 9,46984
A0AAE9KWC9 154 9,36095
A0AAE9KWL3 154 9,36095
A0AAE9VJ99 154 9,23395
A0AAE9VVU0 154 9,32453
A0AAE9WHH5 154 9,23395
A0AAE9WN46 154 9,23395
A0AAF0B1B7 154 9,23395
A0AAX3C193 154 9,23395
A0AAX4M582 154 9,23395
A0AB39C368 154 9,36095
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37963
5hjd8
 62 38,4% 416 2.095E-60
2 phalp2_37960
5fckM
 10 34,0% 411 1.023E-43

Domains

Domains [InterPro]
GH24
Unannotated
Unannotated
Representative sequence (used for alignment): 1pDJr (408 AA)
Member sequence: A0A7S5PMJ4 (154 AA)
1 408 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Escherichia phage Andreotti
[NCBI] 		2706841 Felixounavirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN850610 [NCBI]
CDS location
range 76009 -> 76473
strand +
CDS
ATGCAACTCTCAAGAAAAGGTTTAGAAGCTATTAAGTTCTTTGAAGGTCTTAAGCTTGAGGCTTACGAAGATTCTGCTGGAATCCCCACAATTGGGTATGGGACAATTCGTATTGGTGGGAAGCCTGTTAAGATGGGTATGAAGATTACCGCTGAACAAGCTGAACAGTATCTTCTCGCAGATGTTGAAAAGTTCGTTGCAGCAGTGAACAAAGCTATCAAGATTCCAACTTCTCAGAACGAGTTTGATGCACTTGTAAGTGAAACATACAACATTGGTATCACAGCTATGCAGGACTCTACATTTATCAAGCGCCACAACGCTGGTAATAAGGTAGGTTGTGCAGAAGCTATGCAGTGGTGGAACAAGGTTACAGTCAAAGGTCAGAAGGTCACTTCAAACGGCCTGAAAAACAGACGTAGAATGGAAGCTGACATTTATCTTGACAGTGTATACCCAAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1pDJr) rather than this protein.
PDB ID
1pDJr
Method AlphaFoldv2
Resolution 71.43
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50