Protein

Protein accession
A0A7G9A347 [UniProt]
Representative
7ZyR0
Source
UniProt (cluster: phalp2_1607)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAKFSSLITGTTPDHGKNRGSDPNKKRIIVHHWAGTSGGDTALMKPKGQNSRGDVSASYILYSDGRLVGQVSEDKSPWTTGSADWGSVTVETQNAKGAPNWDIDPRAKEKLAQLMADLSDRYGWGELKLGTNVRMHREFNATACPGPDMVASLPSIVARANQLRKGGGGSQPSTGGTYTVVKGDTLSGIAGKHGTTWQELQKLNGLADPNKIYPGQKLKVPSGGGSTPSKPSQSISDVAKAVIRGDYGNGQDRVNRLRAAGYDPAEVQQEVNRQLYGGGSKTPVASNTDAIARQVIRGDWGNDPQRKQRLTAAGYDYSAIQRRVNEILAGK
Physico‐chemical
properties
protein length:331 AA
molecular weight:35312,9 Da
isoelectric point:9,70
hydropathy:-0,71
Representative Protein Details
Accession
7ZyR0
Protein name
7ZyR0
Sequence length
335 AA
Molecular weight
36563,08020 Da
Isoelectric point
6,70970
Sequence
MKNWNTVDADIVQLMNRHYTPGRDGESIRFITIHHNAANLTVGGCWQTWQNRPASAHYQVEENGTIGQLVWDRDTAWHAGTWNANIKSIGIEHADKLINGQWQLTQTALDNGAHLVAALCKMYNLGTPQWGVNVFPHSRFSSTACPASLQGTQNGEYMRLAQSYYSQMNGGAAVAPAPAEQTSNEKRGRKDNDTIAAEVIQGLWGVGADRANKLSQAGYDYNLVQSLVNQKLGMGTGTSQPAQSIDSIARAVINGEYGNGDERARRLEAAGYDYAVVQAKVNELLGQSNTAAQDLTAIARRVINGEFGNGDTRRARLQAAGYDYQAVQARVNQLV
Other Proteins in cluster: phalp2_1607
Total (incl. this protein): 345 Avg length: 296,3 Avg pI: 8,22
Protein ID Length (AA) pI
7ZyR0 335 6,70970
11A5C 248 9,77168
11xz2 288 9,98862
11zij 286 9,68781
11zmR 294 10,06276
13s4m 327 8,91877
14Gqz 300 8,69203
14ztW 286 9,74583
1DVL5 335 9,11256
1Id7L 283 9,43490
1IfjL 229 8,54092
1IvAw 281 8,78145
1IvZv 280 6,86413
1LNKd 322 9,64578
1cXNX 286 9,99442
1cyax 307 9,76021
1dg1n 313 6,75375
1fQnk 326 9,67105
1fR7S 286 9,94962
1fR8o 233 9,63366
1hOfy 286 8,91225
1hSgw 253 5,72115
1jGON 273 8,79254
1kZ41 295 4,97446
1kfAT 356 4,96951
1lPHB 283 9,11178
1lWEg 269 9,37855
1lWuc 280 9,72294
1nSD9 273 8,90458
1ojBO 273 5,57905
1orlj 269 9,34716
1osPY 274 10,03523
1zFMB 299 4,94763
21nMd 327 9,39706
23xvx 331 4,73829
242g3 279 8,95416
24Cbr 300 5,20414
2GFUa 286 9,84195
2Qxkr 383 9,50736
2SNYN 256 5,92657
2SdTN 276 6,02774
2SpOp 274 5,63493
2TgWb 253 6,25010
2XkiQ 333 9,60774
2YpEo 283 10,16758
2ekpK 336 9,38029
2lWex 376 6,04610
2qNyS 286 10,06327
38Pxy 307 9,57596
3A3NF 289 6,22997
3Mb1f 289 9,78013
3Mb8t 290 9,85942
3MhCf 286 9,21532
3NHLV 291 10,01460
3PIEi 275 8,84256
3bVPv 270 6,01393
3bWK4 292 5,97369
3c8lC 307 9,84163
3dKZj 243 10,01769
3dKh4 242 9,93421
3ebxW 294 9,82680
3edow 243 9,98817
3eelP 290 10,06527
3gZhz 383 9,70979
3iiz3 459 8,41662
3iu8W 439 9,05860
3jTBZ 269 9,24633
3jTwe 271 8,30541
3jTx9 273 9,94278
3klbs 324 8,57953
3lUug 322 8,57347
3lgNs 355 5,33868
3nASz 243 9,10611
3nHeX 257 8,59720
3rdU5 326 8,72233
402hV 285 9,82145
40wDB 285 10,02549
415Mt 280 9,69419
4CMRW 282 7,88082
4IFOJ 284 6,01632
4Jj17 294 9,70322
4JjVX 282 9,48660
4JmsH 284 9,15846
4KNCk 363 10,14192
4N3QK 362 10,14192
4QJTq 251 9,98540
4QlOG 336 9,74100
4Tmey 238 9,74248
4UGR4 383 9,11391
4VeHi 360 10,54002
4W3nN 386 6,51855
4XR2t 286 9,87412
4XSQN 295 9,73332
4Xvjy 289 9,93459
4uny3 228 9,26631
4uuxm 230 9,23904
4vCOA 283 9,18534
4wAD9 282 9,14021
4xoAv 334 9,12590
5BE97 291 5,55433
5BnyW 245 9,93582
5EXZ 392 9,42800
5GJd8 279 6,24668
5H4br 336 9,36192
5HIrp 279 9,53025
5HNvK 320 4,84197
5HbYP 284 8,88834
5JLpq 292 9,76388
5MFdr 352 8,58379
5NJQN 287 9,37301
5Nl23 304 4,95877
5QvKN 305 5,32152
5RRh8 331 9,12358
5TAya 278 8,87325
5V1FZ 292 9,34110
5WDsN 303 7,75786
5Xi7t 301 4,30887
5Xl3W 278 6,12192
5YS9h 352 7,19124
5i2BC 294 9,86664
5jKG8 279 8,63465
5nMVa 389 4,67594
5nN6w 389 4,72147
5nP70 280 7,33947
5oFBq 274 7,81797
5oGRY 319 6,16222
5oGSV 276 9,18315
5oGVW 318 9,79921
5tFSX 277 9,63649
5tGfn 318 9,97063
5tSO6 276 9,62992
5zWkT 291 5,58366
607Cn 285 4,84350
607pz 303 6,60119
60jB1 302 8,43983
60vcO 285 4,91330
61JfS 329 6,70310
63gGL 331 5,68199
64wO3 331 9,12352
66PQA 323 5,08382
66wim 278 8,91554
670Qd 352 7,76900
6AjyW 336 9,18225
6CHeF 277 6,97928
6CLkC 282 6,16558
6CMlV 282 5,98500
6CcJw 245 6,35354
6DJCA 277 7,87741
6DTP4 280 7,28746
6Df95 243 9,92957
6Dh67 279 7,94265
6Dnna 291 9,66731
6DxCP 248 9,64204
6EAUz 291 9,65764
6EqQ9 280 6,83173
6F5YH 277 7,30650
6FmFP 279 8,55968
6Ft83 289 9,83957
6H2pE 278 6,44863
6HRHK 281 6,52122
6Je90 282 8,73116
6KJhZ 291 9,71734
6KNJT 334 9,07949
6KNNL 287 9,51897
6N8Kc 277 8,86139
6N9oc 277 7,30565
6Od5E 279 8,03613
6RRiP 294 9,75473
6RRyX 245 9,66918
6S3e3 277 8,83876
6S3oj 283 9,03068
6S50s 286 9,97302
6SIPt 293 9,86510
6SIUD 282 7,89597
6SJ5T 291 9,60265
6SLS4 279 9,28527
6SQyo 282 8,92192
6STcG 334 8,91109
6VOe8 250 9,84814
6W54t 276 6,08964
6W7ex 282 9,47029
6YYbD 270 8,30541
6ZTNv 272 9,30003
6dOjs 304 4,93137
6dT61 352 8,29374
6eUyj 294 9,39125
6hP4w 352 7,75883
6hrJL 274 5,89349
6hwCV 280 9,24485
6jJdb 380 9,75305
6jyfo 301 4,32507
6oKZL 318 8,99942
6scmK 363 9,91777
6sxXd 264 5,90633
6uw5u 280 9,48383
70Bec 304 4,83276
71Gn0 283 9,31389
71Uv9 280 9,72294
72Xo9 271 8,60519
72vGP 270 7,73848
72x9J 279 8,82013
73Jks 326 8,78667
73mKp 298 5,90787
74ASL 298 5,78254
74ATc 298 6,04098
74fuY 270 7,73814
75Z6u 268 6,78904
78pK 274 5,55279
7AcQF 281 4,88965
7BQsv 271 9,24388
7BY8I 268 9,29758
7C1mg 278 9,68226
7E5ZV 289 10,09996
7I1ZH 274 5,71854
7Ih3g 250 5,36409
7KjtJ 323 9,41601
7M67g 301 4,30597
7NNsH 346 8,91077
7ZBgp 403 4,45540
7ZDIO 352 8,58379
7czYM 280 8,82239
7d1Kq 268 9,59955
7d35X 283 9,04184
7dI5U 278 8,74973
7dRnP 258 9,95503
7hCxG 271 8,62531
7iQ4K 283 5,87871
7iQ5D 275 8,62518
7k8gi 273 8,85997
7kyBZ 255 8,60564
7kyCK 255 8,97356
7o06U 283 8,84205
7p9hH 270 7,11388
7p9j2 269 9,44122
7pj2j 314 7,72632
7plU9 255 8,61531
7plWw 255 8,61538
7q1Qc 325 9,14550
7qH4S 280 9,66254
7qH4v 270 8,62498
7qH5x 272 8,54582
7qJ1v 280 9,66254
7qJqE 269 9,33040
7qOvB 328 4,74699
7qQGr 280 9,66254
7qQUB 280 9,70315
7qR0y 280 8,19736
7qURJ 269 9,33040
7qUqD 269 9,86967
7qUqf 282 8,62756
7qxlE 271 8,55439
7qxqq 256 7,07858
7qyoJ 271 9,36089
7r2lW 279 9,53225
7rOb9 351 9,74744
7rObn 351 9,86174
7rPwj 322 8,91464
7rYXq 280 9,72294
7rq99 334 6,04314
7rq9M 335 6,75477
7s41H 302 5,59412
7s5Xw 271 7,70301
7s5Yk 273 8,60519
7s6LZ 277 8,30535
7s9vw 231 9,57692
7smcf 335 9,18180
7t6kP 328 9,33420
7t9OZ 280 4,94922
7tHNs 277 8,61499
7tRqC 298 6,35331
7uMR 300 6,25657
7ubmh 274 9,28321
7ues0 325 5,68654
7uiD4 280 8,22612
7uka3 269 9,41588
7ukmJ 280 9,40737
7ulp9 274 9,16684
7v752 280 9,70315
7vYrp 347 9,55488
7wekG 277 9,40711
7xGtC 315 8,67991
7yGkj 280 9,61805
7yjDI 325 9,08142
7zQhr 331 9,75814
7zbC7 279 5,82619
7zbLi 279 5,90741
7zbUb 280 7,64555
7zbXW 278 8,87325
7zbu2 280 7,68716
853N1 304 4,83276
86wpQ 307 9,44038
8IAfv 267 4,51008
8JT9M 291 10,01402
8JT9N 289 9,98810
8JT9O 290 9,99029
8JT9P 289 10,01453
8JT9R 289 9,96528
8KrCa 270 9,59826
8KrCi 317 4,90216
8LnBK 330 9,83415
8bEj4 304 4,87317
8eNln 352 6,85589
8eW2d 360 9,97095
8hlus 304 4,84981
8hrWQ 247 6,15478
8i3Do 300 6,17728
8mFqF 352 8,28266
8nehW 260 8,30322
8qUg2 301 4,26175
8r4pX 327 5,68654
8r7FQ 301 4,32507
8tMaZ 352 6,29136
8tOB6 346 6,29068
CGL2 283 9,73758
EXtK 327 8,57347
No1u 403 4,41357
O3Eo 271 9,33162
QOmi 288 10,23959
YoXF 274 6,03047
ZVpT 286 9,92576
bhVa 291 5,30168
bk60 293 9,98359
bknj 336 7,73905
bnXw 274 5,66909
boAh 295 9,82764
bsGV 303 5,59662
dE2 280 9,66254
dF0 270 8,98646
e7Yb 256 5,92657
fGq4 253 5,72115
fIPM 288 9,73784
gh67 288 5,17675
gkEv 274 5,54916
ntza 278 8,80865
yj6L 403 4,41357
A0A2P1CFA9 331 9,75814
A0A2P1CEX4 330 9,83415
A0A4D6E2K7 331 9,64371
A0A4D6E508 334 9,44670
A0A4D6E595 332 9,70277
A0A4D6T757 334 9,44670
A0A514DGM4 331 9,58247
A0AA96GSN4 330 9,77897
A0AA96H6G6 330 9,77897
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_20487
3X7ua
 81 35,8% 324 5.016E-98
2 phalp2_6225
6oM64
 106 52,8% 214 6.808E-92
3 phalp2_14834
7s5S0
 47 38,6% 334 8.874E-80
4 phalp2_4921
6qvcZ
 45 41,6% 300 1.988E-75
5 phalp2_10280
1cMFf
 75 29,5% 325 1.811E-66
6 phalp2_11417
eYHn
 21 33,4% 272 2.736E-54
7 phalp2_15173
ovmV
 70 26,3% 300 4.956E-49
8 phalp2_2897
yopH
 100 32,6% 276 3.929E-45
9 phalp2_5937
6aZNZ
 614 23,6% 283 1.353E-44
10 phalp2_28103
7vQh7
 9 32,8% 222 4.187E-39

Domains

Domains [InterPro]
Ami2
CW_7
CW_7
CW_7
Representative sequence (used for alignment): 7ZyR0 (335 AA)
Member sequence: A0A7G9A347 (331 AA)
1 335 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF08230

Taxonomy

  Name Taxonomy ID Lineage
Phage Microbacterium phage Kauala
[NCBI] 		2743403 Kojivirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MT657344 [NCBI]
CDS location
range 18628 -> 19623
strand +
CDS
ATGGCCAAGTTCAGCAGCCTGATCACCGGCACCACGCCGGATCACGGCAAGAACCGGGGCAGCGACCCGAACAAGAAGCGGATCATCGTTCACCACTGGGCGGGCACGTCCGGCGGCGACACCGCGCTGATGAAGCCCAAGGGCCAGAACAGCCGTGGCGATGTGTCTGCGTCGTACATCCTGTACAGCGATGGTCGCCTGGTGGGCCAGGTCTCGGAGGACAAGTCCCCGTGGACCACCGGCTCGGCTGACTGGGGTTCGGTTACGGTCGAGACCCAGAACGCCAAGGGTGCCCCGAACTGGGACATCGACCCCCGTGCGAAGGAGAAGCTGGCTCAGCTCATGGCGGACCTCAGCGACCGCTACGGCTGGGGCGAGCTGAAGCTCGGCACGAACGTCCGGATGCACCGCGAGTTCAACGCCACGGCCTGTCCTGGCCCCGACATGGTGGCCAGCCTGCCCAGCATCGTCGCCCGCGCGAACCAGCTCCGCAAGGGCGGGGGCGGCAGCCAGCCGTCCACCGGGGGCACCTACACCGTCGTGAAGGGCGACACGCTCAGCGGCATCGCGGGCAAGCACGGCACGACCTGGCAGGAGCTCCAGAAGCTCAACGGCCTGGCCGACCCGAACAAGATCTACCCCGGCCAGAAGCTGAAGGTGCCGTCGGGCGGGGGCAGCACCCCCAGCAAGCCCAGCCAGTCCATCTCTGATGTGGCCAAGGCCGTCATCCGTGGCGACTACGGCAACGGTCAGGACCGCGTCAACCGGCTGCGCGCTGCTGGCTACGACCCCGCCGAAGTGCAGCAGGAGGTCAACCGCCAGCTCTACGGAGGCGGCAGCAAGACCCCTGTCGCGTCCAACACGGATGCCATCGCGCGCCAGGTGATCCGGGGCGACTGGGGCAACGACCCCCAGCGGAAGCAGCGCCTGACGGCTGCGGGGTACGACTACTCCGCCATCCAGCGCCGCGTGAACGAGATCCTCGCGGGCAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7ZyR0) rather than this protein.
PDB ID
7ZyR0
Method AlphaFoldv2
Resolution 84.04
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50