Protein

Protein accession
A0A7D7F147 [UniProt]
Representative
1Mo76
Source
UniProt (cluster: phalp2_38866)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKLSQRGIDLIKQFEGYSSKAYPDPATGGAPWTIGYGTTKGVKPGMIITAEQAEKMLRDDVAKFESGVSSLITAPTTQGQFDAMVSLAYNIGLGNFGKSTLLKKHNARCYTCAADQFRVWNRANGKVMNGLTKRRAAERQVYMS
Physico‐chemical
properties
protein length:144 AA
molecular weight:15748,9 Da
isoelectric point:9,73
hydropathy:-0,39
Representative Protein Details
Accession
1Mo76
Protein name
1Mo76
Sequence length
336 AA
Molecular weight
35367,78870 Da
Isoelectric point
9,45198
Sequence
MKTSPAGRQAIAHHEGNRLKAYPDPATGGDPWTIGVGHTSAAGPPKVTKGMTITAEESDAILTRDLATFERAVERAVKVPVTQNQFDAMVSLAFNIGGGNFAKSTLVKKLNAGDIASAADAFLSWNKAAGKVMKGLKTRRAAERKLFLSGGSAPVAKPEEPKNEPRSQPNEFDSILHNGSRSQFVKRLQQNLNTLGYGPVMVDGRFGDQTETAVVAFQHDNGLEPDGWAGPHTLEAIGKAIKDRETAPKIAAAKDVVDDAASNGISKTEVITTVTGVGGVATVVKETVDSVKDGASSLLSLGPWILLALVIAGGAAFVIWDRRRKRLAANAAKAVM
Other Proteins in cluster: phalp2_38866
Total (incl. this protein): 29 Avg length: 256,1 Avg pI: 9,41
Protein ID Length (AA) pI
1Mo76 336 9,45198
15O0v 407 9,73732
1KDSc 333 9,73145
1lwYN 352 7,66357
1rFTg 279 9,00032
5Hbvt 327 8,70260
6RWAJ 344 9,69135
6x40a 345 9,87973
71TaZ 383 9,26238
7d3hr 260 8,60107
7rSHK 275 9,41762
7vPGT 339 9,59691
7wTHV 262 9,09541
8Hj38 327 9,24897
8pOxv 332 9,60793
Qens 346 9,46062
bjZL 332 9,51781
A0A411AV83 144 9,72842
R9TMH8 144 9,72842
A0A6G9LBT2 201 9,95232
R9VWD7 150 9,20488
A0A193GZ38 163 9,48731
A0AAE8XHU3 144 9,82480
A0A6G5Y8L3 149 9,66157
A0A6J7VSQ6 165 9,99068
A0A8S5LZ44 144 9,82480
A0AAE8YFQ8 150 8,70737
D6QWN7 149 9,37785
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_34307
3A2Hz
 178 42,1% 242 1.256E-60
2 phalp2_22247
7g4te
 1 38,4% 252 1.114E-54
3 phalp2_9590
1qPJJ
 8 38,6% 243 2.829E-54
4 phalp2_40579
4SZ2W
 11 33,8% 334 4.283E-50
5 phalp2_28322
16R6i
 5 34,1% 249 6.693E-42
6 phalp2_13854
7rIjv
 1 33,8% 263 1.984E-40
7 phalp2_16965
86QY9
 61 36,1% 235 1.258E-39
8 phalp2_36335
j9L3
 5 33,5% 313 2.003E-38
9 phalp2_6611
1poy8
 1 35,3% 243 3.696E-36
10 phalp2_27796
7vIKE
 3 31,7% 236 1.259E-35

Domains

Domains [InterPro]
GH24
PG_1
Unannotated
Disordered region
Representative sequence (used for alignment): 1Mo76 (336 AA)
Member sequence: A0A7D7F147 (144 AA)
1 336 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Klebsiella virus KpV2811
[NCBI] 		2759464 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MT682064 [NCBI]
CDS location
range 34605 -> 35039
strand -
CDS
ATGAAACTATCGCAGCGTGGCATTGATTTAATTAAACAATTCGAGGGTTACAGCTCGAAGGCATATCCAGACCCAGCCACTGGCGGAGCGCCGTGGACTATCGGTTACGGTACAACCAAAGGCGTTAAGCCAGGCATGATTATCACCGCAGAACAAGCGGAAAAGATGCTGCGTGACGACGTAGCGAAATTTGAAAGCGGCGTCTCGTCACTCATCACCGCCCCAACAACTCAGGGCCAGTTTGATGCAATGGTGTCGCTGGCCTATAACATCGGGCTTGGTAACTTTGGCAAATCAACTCTGCTGAAAAAGCATAACGCCCGCTGCTACACCTGCGCCGCCGACCAGTTCCGGGTGTGGAATCGTGCTAATGGCAAGGTCATGAACGGACTCACCAAGCGCCGCGCCGCTGAACGTCAGGTCTACATGTCATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1Mo76) rather than this protein.
PDB ID
1Mo76
Method AlphaFoldv2
Resolution 75.87
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50