Protein

Protein accession
A0A6M5C8W4 [UniProt]
Representative
4nPQZ
Source
UniProt (cluster: phalp2_14378)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSLRTKVVAALTGATMLGGAITGVIQHNEGLSLTAYKDSAGIPTICYGETKGVKMGQRATLSDCQKQLIQSAGEHAKALDGLPMQLSDVSLTGSLDFTYNIGVSGFNESAVKPHLKRLDHAAAAKSVLAWRYISKYQQKSPGTGWVYKGGNRWTFDCSQYINGQRNKVCWGLWERRQWQSKAIGNQFKDVNTAVAALMKTGG
Physico‐chemical
properties
protein length:202 AA
molecular weight:21903,8 Da
isoelectric point:9,62
hydropathy:-0,30
Representative Protein Details
Accession
4nPQZ
Protein name
4nPQZ
Sequence length
206 AA
Molecular weight
23392,58930 Da
Isoelectric point
9,28914
Sequence
MDLKSTIKGISAGVIFLFGTSVVTFEGLPSMNPNGSYSPYKDPIGITTLCYGYVPQMTEAIQKEYTKKECDVLLDKTLYKYTVVLNNLPVMPVSTTVGFLDFAYNTGINAANSSTVKKRLAEGNYAQASKAVLQWRYVSQKKPDYSKGRWEHRNGKYYYDCSQYHQGKPNKLCYGLYTRRLMESELLAGTMTNKEEIQKYIHKFGK
Other Proteins in cluster: phalp2_14378
Total (incl. this protein): 9 Avg length: 195,4 Avg pI: 9,34
Protein ID Length (AA) pI
4nPQZ 206 9,28914
1a4p3 206 9,03313
1cn5Y 206 9,21629
1k1Ik 176 9,15698
7oFgr 206 9,05570
7yl5I 206 9,14653
A0A1J0MIA3 145 9,88753
A0AA50F3F4 206 9,61502
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_21319
1KsyR
 184 34,3% 166 6.352E-28
2 phalp2_22286
7A6Fj
 714 29,5% 193 6.139E-16
3 phalp2_9097
5EHW9
 11 23,5% 191 1.293E-12
4 phalp2_12784
8jI3j
 17 28,1% 167 2.065E-08
5 phalp2_16580
7BuG7
 798 21,3% 192 3.280E-06
6 phalp2_23830
1lpLy
 242 24,6% 134 2.725E-04

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 4nPQZ (206 AA)
Member sequence: A0A6M5C8W4 (202 AA)
1 206 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Klebsiella virus 2019KP1
[NCBI] 		2736194 Autographiviridae > Drulisvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MT360680 [NCBI]
CDS location
range 41082 -> 41690
strand +
CDS
ATGAGTTTAAGGACTAAGGTTGTGGCGGCCCTCACGGGGGCCACTATGCTAGGCGGCGCTATTACCGGGGTTATCCAGCACAACGAGGGGTTGAGCCTGACAGCATACAAGGACAGTGCCGGTATCCCTACTATCTGCTATGGCGAAACCAAGGGCGTCAAAATGGGCCAGAGAGCCACTCTGAGCGATTGTCAGAAGCAACTGATACAGTCAGCAGGGGAACATGCAAAGGCCCTTGACGGGCTTCCTATGCAGCTCTCGGATGTATCTCTAACTGGGTCCTTGGACTTCACGTACAACATTGGGGTGTCCGGATTCAACGAGAGTGCGGTAAAGCCGCATTTGAAGCGGCTAGATCATGCAGCTGCAGCTAAGTCTGTGCTGGCCTGGCGTTATATTAGTAAGTACCAACAGAAGTCCCCCGGCACTGGTTGGGTGTACAAGGGCGGGAACCGCTGGACCTTTGACTGCTCCCAGTACATTAACGGGCAACGCAATAAGGTGTGCTGGGGCCTGTGGGAGCGCAGGCAGTGGCAGAGTAAGGCCATTGGGAACCAGTTCAAGGATGTTAATACTGCGGTGGCTGCACTTATGAAGACAGGAGGATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4nPQZ) rather than this protein.
PDB ID
4nPQZ
Method AlphaFoldv2
Resolution 91.67
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50