Protein

Protein accession
A0A6M3BEB5 [UniProt]
Representative
7hCUl
Source
UniProt (cluster: phalp2_30714)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MPHYDVVDTSNNNGTMTKANWLSMKKYGVKAMIAKLSEGTYFTDQTAKPSIRNAVAAGLHVNGYHFARFTTVAGAKVEAQMAARSALNAGLGKNSVIVLDFEATNSGWTQNSKIVKAWINEVHRMGYPKTDVYTMGSWINSVPLNTTGRGGWVANYPYNPSGFKLYTGYNGWQWTSSMHFPGCYGTFDVSQMYSNYYYGTATKAVKPKKAIYYRYNPKMIYARTPINRYKDVAFKHKVDNFPAGTVFAIAKVINYGKITRFQLANGYYITSNQTNVNRLYYSADGGAKRVKSVRGTHRYKDKALKHVVDWQPAGTEFDVAKIVKYGDTTRIQLANGLFISGNKKINKFVK
Physico‐chemical
properties
protein length:350 AA
molecular weight:39270,3 Da
isoelectric point:9,91
hydropathy:-0,44
Representative Protein Details
Accession
7hCUl
Protein name
7hCUl
Sequence length
374 AA
Molecular weight
40952,10180 Da
Isoelectric point
7,59280
Sequence
MKCKLVYMVGLLLAGLFFFSINVDAARTDMVDVSNHNGYMTTANFVDMRNNYGVKSVVTKISEGTYYHDYTAANNISTAQAAGLYINGYHYAKYKTEFQAVAEADYASALAKQDGLPIGAVLVADVEDGSQAGLTKSQMNANNKAFMNQVAKYGYRSDVYTMGSWVNNRFVVPTGTGWIASYPYNASGKSWYSSNNGWQWGSTYKFQGSYGNFDVSQLYTNFYTADQAAKVDPRASISNVVSVKGNDYKAYATFNGKGMANIGTNVISGSDWISASIVAVNDRPYYVIGVDTLIPQAITTFKDKLVINYRSDYGVNAYNSEGQAIKDSNQTFKGGSEWKTSDKLTNVPNVGLCYKVATDEYIPIQYAQGSGFNG
Other Proteins in cluster: phalp2_30714
Total (incl. this protein): 46 Avg length: 367,8 Avg pI: 7,97
Protein ID Length (AA) pI
7hCUl 374 7,59280
1QQ5N 374 9,04390
1QQc3 366 9,16826
1Z0PB 373 6,95251
1gRN1 366 4,94985
2TxFG 305 9,36701
2l4qo 372 8,25178
5iYMO 374 8,69538
6bR7q 388 8,57915
79GJQ 389 7,88734
79GW3 373 8,73387
79JAd 367 8,84611
7BFm3 367 9,00025
7bb9H 358 9,32537
7eqR9 374 8,55136
7f5NY 373 5,41820
7f5O0 373 6,95336
7f5OU 374 6,95780
7fxqy 372 8,26544
7gSxp 377 6,28818
7ibPL 374 8,77648
7lCgB 372 9,51110
7lCik 372 9,54101
7o1BY 365 8,78989
7o1DY 365 8,80943
7o7Re 373 6,89209
7r7EJ 378 9,24253
7t62a 363 9,28714
7tCT0 332 4,70277
7vBGl 377 7,01748
7vQlw 374 6,42300
7vQxm 375 6,47990
7vzby 374 7,66163
7wD8G 351 4,50576
7wDav 351 4,50764
7wDbp 351 4,41817
7wDg7 367 8,66463
7wDgc 367 8,68442
7wLAj 374 8,29368
7z8jE 367 9,08625
7z8kF 369 9,28694
7zBH2 381 9,51065
nnfV 391 9,04751
A0A6M3BEF4 350 9,91280
A0A6G5Y785 365 8,79615
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17635
6JmE3
 482 47,1% 263 2.233E-77
2 phalp2_37990
5tY12
 7 48,3% 242 7.783E-77
3 phalp2_18353
5tR7x
 6 39,0% 251 3.798E-54
4 phalp2_14854
7znRU
 13 28,7% 337 5.787E-30
5 phalp2_12156
6iQWP
 264 29,9% 247 5.012E-20
6 phalp2_387
7iNag
 20 25,1% 413 9.320E-19
7 phalp2_32643
239ef
 4 22,4% 272 1.753E-14
8 phalp2_1050
734XP
 69 24,5% 334 5.359E-12
9 phalp2_17009
8mast
 2 20,9% 286 6.457E-09
10 phalp2_11865
7owpA
 74 20,7% 251 4.219E-06

Domains

Domains [InterPro]
Disordered region
GH25
Unannotated
Representative sequence (used for alignment): 7hCUl (374 AA)
Member sequence: A0A6M3BEB5 (350 AA)
1 374 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage JNU_P2
[NCBI] 		2686382 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN830254 [NCBI]
CDS location
range 26175 -> 27227
strand +
CDS
ATGCCACATTATGATGTTGTGGATACTTCTAATAACAATGGGACCATGACTAAAGCCAATTGGCTATCAATGAAAAAGTATGGTGTTAAAGCCATGATAGCTAAGCTATCCGAAGGCACGTACTTCACTGACCAAACGGCCAAGCCGAGCATTCGTAATGCGGTTGCTGCTGGCTTACACGTCAACGGTTATCACTTTGCCCGATTTACGACAGTGGCTGGGGCTAAGGTCGAAGCTCAAATGGCGGCGCGGAGTGCACTAAATGCCGGCCTAGGTAAGAACAGTGTGATCGTACTTGACTTTGAAGCCACCAATTCTGGCTGGACTCAGAACTCCAAAATTGTTAAGGCCTGGATCAACGAAGTTCATCGCATGGGCTATCCTAAGACGGACGTTTATACAATGGGCAGCTGGATTAATTCAGTGCCTTTGAATACAACCGGTCGGGGTGGTTGGGTCGCAAATTATCCTTACAATCCGTCCGGGTTTAAGCTTTATACCGGATATAATGGTTGGCAATGGACGTCAAGCATGCACTTTCCGGGTTGTTATGGAACGTTTGATGTGTCCCAGATGTACTCTAACTATTACTACGGCACCGCAACCAAGGCAGTTAAACCGAAAAAGGCCATCTACTACCGATACAATCCCAAGATGATCTATGCCCGGACACCGATTAATCGTTACAAGGACGTTGCCTTCAAGCACAAAGTGGACAACTTCCCAGCCGGCACCGTATTTGCGATCGCTAAAGTGATTAACTACGGTAAGATTACTCGGTTCCAGTTGGCAAATGGGTACTATATCACGTCTAACCAAACTAATGTCAATCGCTTATACTATTCCGCTGATGGCGGCGCCAAGCGAGTAAAGTCTGTACGCGGCACTCACCGATACAAGGACAAGGCCCTCAAGCACGTTGTTGACTGGCAACCAGCTGGGACTGAATTTGATGTCGCTAAGATCGTCAAGTATGGAGATACAACTCGGATTCAGTTGGCTAATGGATTATTTATTAGTGGCAACAAAAAGATTAACAAATTTGTCAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7hCUl) rather than this protein.
PDB ID
7hCUl
Method AlphaFoldv2
Resolution 89.01
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50