Protein

Protein accession
A0A6B9IA36 [UniProt]
Representative
5HBET
Source
UniProt (cluster: phalp2_9110)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSLRTKVIAALTGATMLGGAITGVVQHNEGLSLTTYKDSAGVPTICYGETKGVKMGQRATLSDCQRQLIESAGEHAKALDGLPMQLSDVALVGSIDFIYNVGVSGFNGSAVKRHLKSLNYAAAGKAVLDWRYISKYQQKSPGTGWVYKGSNRWTFDCSQYINGQRNRVCWGLWERRQWQSKAIGNQFKDVNTAVAALKKTGH
Physico‐chemical
properties
protein length:202 AA
molecular weight:22020,9 Da
isoelectric point:9,70
hydropathy:-0,29
Representative Protein Details
Accession
5HBET
Protein name
5HBET
Sequence length
104 AA
Molecular weight
11308,02950 Da
Isoelectric point
6,55691
Sequence
MASRLAKNTILAGVLVSLVGGFEGLRTVAYLDPVGIPTVCFGETKGVKLGDRYTKEECKDMLKESLVEHERGMRKCLGRPDDIPDLTYGAFLSFTYNVGVGAFC
Other Proteins in cluster: phalp2_9110
Total (incl. this protein): 95 Avg length: 191,3 Avg pI: 9,45
Protein ID Length (AA) pI
5HBET 104 6,55691
3gBom 98 4,24493
4Ts8O 96 6,05662
6VBCT 88 5,67022
7nLDe 118 9,58118
8bkPr 117 8,95023
8tQhn 111 9,69342
eXCD 131 9,14673
A0A1D8ES60 202 9,59504
A0A2S1ZES1 199 9,64823
Q3HQU9 165 9,14853
A0A0P0HS42 184 9,64855
A0A1B0Z137 202 9,78793
A0A0C5PVL1 202 9,67131
A0A142F120 202 9,78793
A0A068Q6B6 202 9,64855
A0A0S2MXR6 202 9,61780
D1L301 202 9,71940
V9QL51 199 9,67131
A0A482II55 199 9,58092
A0A1U8V571 188 9,64197
A0A0C5Q3S9 202 9,69645
A0A2P0XN13 203 9,24536
A0A1I9SEI7 199 9,69645
A0A5B9NC12 202 9,57383
A0A5B9NC51 202 9,57383
A0A5B9NGL7 202 9,57383
A0A5J6CU92 199 9,69542
A0A5K7NJB8 185 9,53573
A0A6B9I807 202 9,55320
A0A6B9I9N1 202 9,55320
A0A6B9I9S0 202 9,55320
A0A6G5S769 187 9,49486
A0A6G8R436 200 9,69542
A0A6H0X2U1 199 9,61715
A0A6M2YFT1 183 9,19237
A0A6M3YLL6 199 9,74415
A0A7D7FD64 202 9,64855
A0A7L8ZI01 199 9,69574
A0A7R8MJX7 199 9,61754
A0A7R8ML46 199 9,74293
A0A7R8R9W2 199 9,74293
A0A873WEP7 165 9,25458
A0A873WUP5 199 9,69574
A0A8F2F3Z1 191 9,35161
A0A9E7M8E3 202 9,74370
A0A9E7NYK9 198 9,58124
A0A9E7SBL1 207 9,72146
A0A9E7SRK9 180 8,53550
A0A9E8GE14 200 9,71940
A0A9E9C2A1 202 9,81404
A0A9X9JW35 202 9,71940
A0AA96KQP4 202 9,67092
A0AAD2GPQ9 198 9,72146
A0AAD2GSQ3 202 9,76956
A0AAE7SM17 199 9,67131
A0AAE8YHG3 199 9,59504
A0AAE9C7G9 199 9,71940
A0AAE9HC85 199 9,64758
A0AAE9KEM2 199 9,12577
A0AAE9YH45 202 9,81404
A0AAF0D833 203 9,71940
A0AAT9V6A4 207 9,91042
A0AAU7J8L2 202 9,67163
A0AAU7PFZ0 202 9,77001
A0AAV1MCZ5 199 9,69574
A0AAV1MII4 202 9,74409
A0AAV1MIY0 202 9,73958
A0AAX4GET9 202 9,67131
A0AAX4GK36 205 9,64823
A0AAX4GKE5 195 9,42819
A0AAX4GLY1 202 9,78793
A0AAX4GM38 202 9,78793
A0AAX4GMC4 203 9,71940
A0AAX4GMG1 202 9,78793
A0AAX4GMZ3 202 9,67163
A0AAX4GNM7 199 9,67131
A0AAX4GPI5 202 9,64855
A0AAX4GQC1 195 9,44747
A0AAX4GW39 195 9,53573
A0AAX4GWW7 199 9,67131
A0AAX4GX62 199 9,67131
A0AAX4GYE5 202 9,67131
A0AAX4GZT6 202 9,88270
A0AAX4H0M1 202 9,71972
A0AAX4H226 202 9,67163
A0AAX4H271 199 9,67131
A0AAX4H2G9 202 9,67163
A0AAX4Q430 202 9,55417
A0AAX4RFS7 204 9,67163
A0AB39C5X7 202 9,71940
A0AB39TZW6 202 9,67131
A0AB74UPH8 211 9,42697
A0AB74UQD3 202 9,64855
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4305
8aoFg
 2477 52,5% 99 9.684E-36
2 phalp2_11002
4Mz75
 307 44,6% 94 2.338E-27
3 phalp2_2632
6RhYr
 14867 41,0% 100 2.611E-21
4 phalp2_35864
4Lj4w
 95 40,0% 115 1.165E-19
5 phalp2_25155
1IVIw
 4 34,0% 100 3.471E-17
6 phalp2_37312
8djZH
 4 43,0% 86 1.231E-16
7 phalp2_26644
2b0IA
 24 38,7% 80 8.219E-16
8 phalp2_21089
jcH9
 1 36,0% 86 1.128E-15
9 phalp2_31530
48EM7
 20 36,2% 91 2.914E-15
10 phalp2_17749
7tNIh
 28 32,0% 75 5.025E-14

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 5HBET (104 AA)
Member sequence: A0A6B9IA36 (202 AA)
1 104 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Klebsiella phage VLC4
[NCBI] 		2686207 Autographiviridae > Drulisvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN794003 [NCBI]
CDS location
range 43912 -> 44520
strand +
CDS
ATGAGTTTAAGGACTAAGGTTATTGCGGCCCTCACGGGGGCCACTATGCTCGGCGGTGCCATTACCGGCGTAGTCCAGCACAACGAGGGCCTGAGCCTTACCACCTATAAGGATAGTGCCGGTGTCCCTACAATCTGCTACGGGGAGACAAAGGGCGTCAAAATGGGCCAGAGAGCCACGCTGAGCGATTGTCAGAGGCAACTGATAGAATCAGCAGGGGAACATGCAAAGGCCCTTGACGGGCTTCCTATGCAGCTCTCTGACGTAGCCCTGGTTGGGTCCATAGACTTCATTTATAACGTAGGCGTATCTGGCTTCAACGGCAGTGCTGTGAAGCGGCACCTCAAAAGCCTGAATTACGCAGCAGCTGGAAAGGCCGTACTGGACTGGCGCTATATTAGCAAGTACCAGCAGAAGTCCCCCGGCACTGGTTGGGTGTACAAGGGCAGCAACCGCTGGACCTTTGACTGCTCCCAGTACATTAACGGGCAGCGCAATAGAGTGTGCTGGGGATTGTGGGAGCGCAGGCAGTGGCAGAGTAAGGCCATTGGGAACCAGTTCAAGGACGTTAATACAGCTGTGGCGGCACTTAAAAAGACAGGGCACTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

PDB ID
A0A6B9IA36
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A976QNM5
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (5HBET) rather than this protein.
PDB ID
5HBET
Method AlphaFoldv2
Resolution 95.01
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50