Protein

Protein accession
A0A653FRM8 [UniProt]
Representative
7cXTn
Source
UniProt (cluster: phalp2_15038)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MMAGIPKKLKATLLAVTIAGGGVGGYQEMTRQSLIHLENIAYMPYRDIAGVLTVCVGHTGPDIEMRRYSHAECMALLDSDLKPVYAAIDRLVRVPLTPYQKTALATFIFNTGVTAFSKSTLLKKLNAGDYAGARDQMARWVFAAGHKWKGLMNRREVEMAIWNIRGADDLRK
Physico‐chemical
properties
protein length:172 AA
molecular weight:19045,1 Da
isoelectric point:9,62
hydropathy:-0,03
Representative Protein Details
Accession
7cXTn
Protein name
7cXTn
Sequence length
245 AA
Molecular weight
25874,37840 Da
Isoelectric point
9,04590
Sequence
VPNAVHSPPKKLSAVALAVAIATPSVVYFEGRENEAYLDIVGVPTICYGSTSGVKLGQTKTDAECEALLRGELGRTCQRVDQLVTVPMSATRTAALCSFAYNVGTGAFSRSTLLKKLNAGAGDEACAELSRWVYAGGKQVPGLVTRRGVERAVCEWSATDEQIQAASAWVQQAVHIPLSTTRHAALTAYAYGVGLAQLQVSPVVQQLNAGAGAKACVSMTTWPTPASKGELKRRKALQRLCEVVQ
Other Proteins in cluster: phalp2_15038
Total (incl. this protein): 20 Avg length: 165,0 Avg pI: 9,21
Protein ID Length (AA) pI
7cXTn 245 9,04590
A0A0U4JP67 170 9,26084
A0A0A8KXN5 156 7,68397
A0A5C2IBS7 156 7,68431
A0A1L7DQK7 158 9,00025
A0A0C4UQU4 171 9,54398
A0A4Y5TPT6 150 9,35251
A0A514CVS2 157 9,21016
A0A7D3QIX2 171 9,54398
A0A7D3QLQ2 171 9,54398
A0A7D3UKI4 171 9,54398
A0A7D3V4M6 171 9,54398
A0A7D7ESH3 171 9,54398
C9DGM9 171 9,54398
Q9T1X2 171 9,54398
A0A2H4JIE3 82 10,01808
A0AAU6W350 158 9,38442
A0AAX4G9F2 162 8,31689
A0AB74UNV4 165 9,20513
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33347
6Ew8q
 73 38,8% 175 1.493E-36
2 phalp2_2498
5GMvl
 297 41,7% 182 2.464E-35
3 phalp2_17663
6R9yG
 6 44,0% 159 1.168E-34
4 phalp2_37804
4EicH
 34 32,6% 190 5.408E-29
5 phalp2_6008
4MOEK
 54 37,2% 236 1.867E-28
6 phalp2_1458
1J3lb
 7 34,1% 164 1.233E-25
7 phalp2_12815
8ixoy
 26 36,8% 179 4.303E-23
8 phalp2_6732
24SaC
 23 28,4% 176 1.553E-15
9 phalp2_39337
4wcDC
 15 32,4% 157 1.287E-14
10 phalp2_35293
6WTso
 2 22,4% 174 2.609E-13

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 7cXTn (245 AA)
Member sequence: A0A653FRM8 (172 AA)
1 245 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Escherichia virus Mu_3F6
[NCBI] 		2686059 Muvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR595867 [NCBI]
CDS location
range 10685 -> 11203
strand +
CDS
ATGATGGCGGGGATACCAAAAAAACTGAAAGCCACACTGCTGGCTGTAACGATTGCCGGTGGCGGTGTGGGTGGTTATCAGGAAATGACCCGTCAGTCTCTGATCCATCTGGAAAATATCGCTTATATGCCTTACCGCGATATTGCCGGTGTGCTTACGGTCTGTGTGGGACATACCGGGCCGGATATCGAAATGCGCCGTTACAGCCATGCGGAGTGTATGGCTCTCCTCGACAGTGATTTAAAACCGGTTTATGCGGCAATCGATCGTCTTGTCAGGGTGCCGCTGACGCCATATCAGAAAACGGCGCTGGCAACGTTTATTTTCAACACTGGTGTTACCGCATTCAGTAAATCAACGCTGCTGAAAAAACTCAATGCCGGTGATTACGCCGGAGCGCGTGACCAGATGGCCCGCTGGGTGTTTGCCGCAGGCCATAAATGGAAAGGACTGATGAACCGTCGCGAAGTGGAAATGGCAATCTGGAATATCAGGGGGGCGGATGACCTTCGCAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0020002 host cell plasma membrane cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7cXTn) rather than this protein.
PDB ID
7cXTn
Method AlphaFoldv2
Resolution 74.30
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50