Protein

Protein accession
A0A650ESX0 [UniProt]
Representative
79IyY
Source
UniProt (cluster: phalp2_12277)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MNGIDISSYQAELNAGIVPSDFVFIKATEGTNYINPTWREQAGQVTQANKLLGFYHFASTGNPIAEADFFISVVKDYIGKAVLVLDFEAGAINAWGNVGARQFLNRVKEKTGINPMIYMSAEVTRQFNWSIISNTNPLWVAQYASMSPTGYQSAPWTDGKGYGAWSSAAIHQYSSSGSLANWDGHLDLNLAYINANQWKQLAGGSSTAQNNNNSNTNSQLEDDDLMKFTYQIIDAKTGKTQGTIYYYDGNKVVALSHEDQLKIIRQIYKETTGKDLKQYSWRTDAPWYVRFMQAINQKTVEVAWK
Physico‐chemical
properties
protein length:305 AA
molecular weight:34117,7 Da
isoelectric point:6,10
hydropathy:-0,41
Representative Protein Details
Accession
79IyY
Protein name
79IyY
Sequence length
316 AA
Molecular weight
35744,04620 Da
Isoelectric point
5,15924
Sequence
MALKFVDVASHQGNYVVGSSGEEGVIVKATQGTGYLNPYLDYVAQQAISKGIPWGIYHYVGGGDANAEADYFIQSVQGYLNGSNPPNLILDWEEYQNSAYKNGVWAETFLKRLKDKTGIQGGIYGNSDDLSQMTQWVIDNAWVWFAGYPYAPGTTQMIQDWNAPKFPYNKGKFNAITGWQFSSQPLDRSIFYLDTEGWTKLSGSDNANQNNNNSSSATEQNNNNSNNNSQLEDDDLMKFTYQIIDAKTGKKQGTIYYYDGNKVVALSHEDQLKIIRQIYKDTTGKDLKQYSWRTDAPWYVRFMQAINQKTVEVAWK
Other Proteins in cluster: phalp2_12277
Total (incl. this protein): 11 Avg length: 297,7 Avg pI: 5,60
Protein ID Length (AA) pI
79IyY 316 5,15924
4EkrM 293 5,02044
78hrK 295 5,40206
79IxS 284 4,85589
7uG80 284 4,74597
7vkZr 295 5,40206
7xejd 288 4,87090
A0A650EUD7 305 6,84071
Q8LTJ6 305 6,32308
A0A650EU87 305 6,84071
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_38172
72d4D
 103 41,0% 202 2.089E-52
2 phalp2_37341
8v6XY
 562 33,0% 212 9.902E-52
3 phalp2_16579
7zIOC
 8 27,9% 315 7.153E-47
4 phalp2_12276
79roT
 46 32,0% 225 1.815E-46
5 phalp2_36024
5HOPw
 12 33,0% 203 1.220E-43
6 phalp2_35154
5HNke
 1 27,9% 311 7.034E-40
7 phalp2_32821
2L8bh
 41 31,7% 217 6.105E-39
8 phalp2_4274
8cjfF
 9 31,5% 228 1.132E-38
9 phalp2_4660
4CJrS
 5 31,3% 217 1.567E-36
10 phalp2_1614
888Gb
 6 27,6% 210 1.351E-35

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 79IyY (316 AA)
Member sequence: A0A650ESX0 (305 AA)
1 316 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactococcus phage CHPC836
[NCBI] 		2675253 Sandinevirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN689521 [NCBI]
CDS location
range 20107 -> 21024
strand +
CDS
ATGAATGGAATTGACATTTCCAGCTATCAAGCAGAATTGAATGCTGGAATTGTTCCTTCTGACTTTGTATTTATTAAAGCAACGGAGGGAACAAACTATATAAATCCAACTTGGAGAGAACAAGCTGGTCAAGTCACTCAGGCAAATAAGCTTCTAGGTTTCTATCATTTCGCCAGCACTGGCAATCCAATTGCGGAAGCAGACTTTTTTATCAGTGTTGTTAAAGACTATATTGGTAAAGCAGTTCTAGTCTTAGACTTTGAAGCTGGGGCAATTAATGCATGGGGAAATGTTGGCGCTCGTCAATTTTTGAATCGAGTAAAAGAAAAAACTGGCATCAATCCAATGATTTACATGTCAGCAGAAGTTACTCGTCAGTTTAACTGGAGTATAATTTCAAACACTAACCCTTTATGGGTTGCTCAATATGCTTCTATGAGCCCTACTGGTTATCAGTCTGCTCCTTGGACAGATGGCAAAGGATATGGCGCTTGGAGTTCTGCAGCGATTCATCAGTATAGCTCGTCAGGCTCATTGGCTAACTGGGATGGACACCTTGATTTAAACTTGGCTTATATCAACGCTAATCAATGGAAGCAACTGGCTGGTGGAAGTTCTACAGCACAAAATAACAACAACTCAAATACTAATTCACAATTGGAGGATGATGACCTTATGAAATTTACATATCAAATTATTGATGCAAAAACAGGAAAAACGCAAGGAACTATTTACTACTATGATGGAAATAAAGTAGTTGCTTTATCTCATGAAGATCAACTTAAAATTATCCGTCAAATCTATAAAGAGACGACAGGAAAAGACTTGAAACAGTATAGTTGGAGAACAGATGCCCCTTGGTATGTTCGCTTCATGCAAGCAATCAATCAAAAAACAGTAGAAGTTGCATGGAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (79IyY) rather than this protein.
PDB ID
79IyY
Method AlphaFoldv2
Resolution 52.72
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50