Protein

Protein accession
A0A649V211 [UniProt]
Representative
7jRsp
Source
UniProt (cluster: phalp2_2718)
Protein name
Lysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSYTIRNDGMIPNPKTQTVNYGGRQFIVIHSTADLNAIAANIDHYFDSNWSRVYAFTQWAIDDKEAWQNYDNGFRSWGAGNVNGYAWSQIEICEFQDDNRSKAAIANAIQLTKALVNEATAKGVKVEIISHKEAAQMFGGSDHVDPIPYFNRFGYTMDWFRQQVEAANGGSTNGGSTNGGATNGGATSNINITGEKEMKVITITTDGDYYGKKYKAGACFFFTGDSLRYIERPQSLGVFDSLQIPRFRMDAISLLLLIQDLDLKIS
Physico‐chemical
properties
protein length:266 AA
molecular weight:29541,6 Da
isoelectric point:5,40
hydropathy:-0,38
Representative Protein Details
Accession
7jRsp
Protein name
7jRsp
Sequence length
362 AA
Molecular weight
39539,78110 Da
Isoelectric point
9,23730
Sequence
MSYTVRNDGMIPNPKTQTVNYGGRQFIVIHSTADLNATAGNIDQYFDGNWSRVYAFVQWAIDDKEAWQNYDNGFRSWGAGNVNSYAWTQIEICEFQDDNRSKAAIANAIQLTKALVKEATAKGVKVQIISHKEAAEMFGGSDHVDPIPYFNRFGYTMDWFRQQVGAANGGSTQPVNPTPTSSNGFKVEPWNKVQSVDVDGLNIRSSQTAASSSIGTLRKGQTFNATRICRNGQPVKVGNNTYSTWFEVNGHGWVSGAYVTEVGGGYRPNLAIDGYMGPDTIRAMQRVLGTTVDGVISKPSNMVRALQNFLNKKGYGLAVDGSMGPATIKALQKYLGTTQDGVISKPSNMVRALQTRLNTGSL
Other Proteins in cluster: phalp2_2718
Total (incl. this protein): 11 Avg length: 333,6 Avg pI: 8,13
Protein ID Length (AA) pI
7jRsp 362 9,23730
7jRvp 360 9,16162
8L8Gf 362 9,25162
8L8IL 362 9,17599
X4YGT6 362 9,23730
X4YES5 360 9,16162
X4YWB9 362 9,25162
X4YH20 362 9,17599
A0A4Y5MXB7 256 5,25422
B2BTN7 256 5,07813
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_416
7vQHy
 10 33,1% 356 5.556E-42
2 phalp2_22264
7pxLN
 64 36,9% 271 2.757E-29
3 phalp2_2331
4MNkD
 32 31,1% 350 1.030E-19
4 phalp2_4901
5Zr0m
 117 29,6% 381 3.657E-16
5 phalp2_11198
68WMu
 78 29,2% 256 2.765E-12
6 phalp2_8197
7eZhu
 48 28,3% 236 1.501E-10
7 phalp2_17404
4N8WS
 3 26,6% 300 2.652E-10
8 phalp2_7313
4e1GY
 5 24,9% 309 4.532E-09
9 phalp2_3964
7rht2
 43 24,9% 361 2.478E-08
10 phalp2_3799
62IDO
 4 25,1% 243 1.791E-07

Domains

Domains [InterPro]
Ami2
Unannotated
Unannotated
Representative sequence (used for alignment): 7jRsp (362 AA)
Member sequence: A0A649V211 (266 AA)
1 362 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactococcus phage P1046
[NCBI] 		2662294 Fremauxvirus > Fremauxvirus CHPC971
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN552143 [NCBI]
CDS location
range 48342 -> 49142
strand +
CDS
ATGAGTTATACTATACGTAATGATGGGATGATTCCCAATCCAAAGACTCAAACTGTTAATTATGGTGGTCGACAATTTATTGTTATCCATTCAACTGCAGACTTAAATGCAATAGCTGCTAATATTGACCACTACTTTGACAGTAACTGGTCTAGGGTATATGCATTTACTCAATGGGCAATCGATGACAAAGAAGCATGGCAAAACTATGACAACGGATTTAGATCATGGGGTGCCGGAAATGTTAATGGTTACGCTTGGTCACAAATTGAAATCTGTGAGTTCCAAGACGATAACCGTTCTAAAGCTGCAATCGCTAATGCAATCCAATTAACAAAAGCATTGGTTAACGAGGCTACAGCTAAAGGTGTTAAGGTTGAAATCATCTCACACAAAGAAGCTGCACAAATGTTTGGTGGTTCAGACCATGTTGACCCAATTCCATACTTCAACCGTTTTGGTTATACAATGGACTGGTTCCGTCAACAAGTCGAAGCTGCTAATGGTGGATCTACTAATGGTGGATCTACTAATGGTGGCGCTACTAATGGTGGCGCTACTTCAAATATTAATATTACAGGAGAAAAAGAAATGAAAGTTATTACTATTACTACAGACGGCGATTATTACGGAAAAAAATATAAAGCAGGAGCTTGCTTCTTCTTCACTGGCGATTCGCTTCGTTATATTGAACGCCCACAATCTTTAGGAGTATTCGATTCACTTCAAATACCACGTTTTAGAATGGATGCTATATCATTACTTCTTCTTATTCAAGATTTGGATCTAAAAATCAGCTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. N/A UniProt

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7jRsp) rather than this protein.
PDB ID
7jRsp
Method AlphaFoldv2
Resolution 86.99
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50