Protein

Protein accession
A0A5Q2F7K4 [UniProt]
Representative
dE3R
Source
UniProt (cluster: phalp2_6411)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MEVSQKGQQALEVMEGFSAKAYLDVAGVPTIGFGDTSVRARKVKMGDTTTLEAAKAELALDLHDFKSGVEKYLAKAAKGTTQNQFDALVIFAYNVGLTNFASSSVLRNHLAGDFEAAAKSFALWNKITVKGKKVVSKGLVNRRAKEIEIYLHSNYGV
Physico‐chemical
properties
protein length:157 AA
molecular weight:16990,3 Da
isoelectric point:9,37
hydropathy:-0,10
Representative Protein Details
Accession
dE3R
Protein name
dE3R
Sequence length
103 AA
Molecular weight
11147,76440 Da
Isoelectric point
11,66435
Sequence
MVITRAEAESLLRKDLSRFEAAVARAAPNATDNQFAAFVSLAFNIGISAFVRSTALRRHLAGDHQGAAAGIKLWNKGTVRGKRVVLRGLVTRRAREAALYLTA
Other Proteins in cluster: phalp2_6411
Total (incl. this protein): 10 Avg length: 141,9 Avg pI: 9,67
Protein ID Length (AA) pI
dE3R 103 11,66435
1NCOw 108 9,76027
G0YPI9 157 9,39699
B8QTT5 157 9,37082
H6VUC2 109 9,69084
A0A346FHS8 157 9,37082
A0A5B9N2I1 157 9,37082
A0A6B9RGH8 157 9,37082
A0AAU8EH99 157 9,37082
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33221
5jbqV
 447 50,0% 104 1.877E-25
2 phalp2_2632
6RhYr
 14867 49,0% 100 8.379E-24
3 phalp2_11002
4Mz75
 307 47,1% 104 1.578E-23
4 phalp2_37101
1bvx6
 877 46,4% 99 3.740E-22
5 phalp2_31105
1YRHZ
 456 45,0% 100 3.740E-22
6 phalp2_4451
31DIk
 4919 47,0% 100 1.821E-21
7 phalp2_20456
3zJV8
 14 49,3% 79 4.706E-21
8 phalp2_4305
8aoFg
 2477 41,1% 102 3.144E-20
9 phalp2_9410
8Hj1q
 5109 45,0% 100 3.957E-19
10 phalp2_7764
77796
 37 50,7% 71 3.628E-18

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): dE3R (103 AA)
Member sequence: A0A5Q2F7K4 (157 AA)
1 103 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Salmonella phage ST-3
[NCBI] 		2663323 Kolesnikvirus > Kolesnikvirus Ea214
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN604407 [NCBI]
CDS location
range 77041 -> 77514
strand -
CDS
ATGGAAGTTTCTCAAAAAGGTCAGCAAGCCCTTGAGGTAATGGAAGGGTTCAGTGCAAAAGCATATCTTGACGTTGCAGGTGTACCGACTATTGGATTCGGTGATACCAGTGTTCGTGCAAGAAAGGTTAAGATGGGTGATACAACCACTCTCGAAGCCGCTAAAGCTGAACTCGCTCTGGACTTGCACGACTTCAAATCAGGTGTTGAAAAATACCTTGCTAAGGCCGCAAAAGGCACAACGCAGAATCAGTTTGACGCTCTTGTAATCTTCGCGTATAACGTGGGATTGACTAACTTTGCTTCTTCAAGTGTTCTGAGAAATCACTTGGCAGGTGACTTTGAAGCTGCTGCAAAATCATTTGCACTGTGGAATAAAATCACTGTCAAGGGTAAGAAGGTTGTCAGCAAAGGTCTGGTAAACAGACGTGCAAAAGAGATTGAAATCTACTTGCACAGCAATTATGGCGTTTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
A0A5B9N2I1
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A5Q2F7K4
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A6B9RGH8
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (dE3R) rather than this protein.
PDB ID
dE3R
Method AlphaFoldv2
Resolution 94.15
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50