Protein

Protein accession
A0A5J6TSK3 [UniProt]
Representative
7cxQw
Source
UniProt (cluster: phalp2_18569)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTLGPVTVDWHQRFDFGGPRRHPILGICIHTTENDPGTPAENVAGYQLRTRSGSYHRLVDDAGRVLLENTDDWTTWSSGNLGNDVLLHVAVVARANMTRAQWLAPERARMFEALAQVVAYWCRTHGIPPVILDGPDLLKNKRGLYGHDDTRIWGGTDHTDPGPGFPWQALADRVTAINNPNTPPPPPVGGPTMTDADRQMLLEIWDQLRGPGGNGWPQLGGRTLVDAVAELLPEESAR
Physico‐chemical
properties
protein length:238 AA
molecular weight:26168,1 Da
isoelectric point:5,56
hydropathy:-0,46
Representative Protein Details
Accession
7cxQw
Protein name
7cxQw
Sequence length
257 AA
Molecular weight
28129,51070 Da
Isoelectric point
8,82322
Sequence
LKYTLDWHERFTFGGPRPTSGIFGICVHTTENDAGTPAENVANYQITSESGSYHVLVDSRGRTLLANTDGWIVWASGNVGNNWLIHISFVARAAWKREKWLEYPNMLRAGAKVAANRCKLYGIPPVKLTASQLRQKQKGFVGHLETGQAWGGTDHTDPGSGFPWDVFLNMVKEEMNRGDNTPPPPAAKPAPQPKGFTMSTEARLILDQLAGPEQEGGVPKFTGWPQLGGRTVVDALAAVGEALKVPGMFDPHNKEKR
Other Proteins in cluster: phalp2_18569
Total (incl. this protein): 45 Avg length: 262,3 Avg pI: 7,18
Protein ID Length (AA) pI
7cxQw 257 8,82322
1FXAV 247 6,16154
1dOXh 268 5,75543
1dPA5 268 6,06099
1e8BO 272 6,60102
1emaH 270 5,71149
1epk8 270 5,62498
20KyJ 278 9,14963
23YcB 267 9,51013
23ZDQ 266 9,20997
255OA 278 9,05853
3AU1k 255 7,81578
458d2 279 8,70434
4Mcho 266 9,20997
5ClSU 266 9,20997
61gIO 272 8,32714
652R2 270 5,85086
6XYIf 278 9,12668
718TC 270 6,25430
72Lz8 269 5,73286
76ruE 230 6,41567
79J00 291 6,26652
7ByVU 268 7,89359
7PtPn 236 6,36554
7cIHv 313 6,43835
7m7Ts 248 7,82313
7mBaZ 238 6,28448
7mBhY 238 6,21974
7ogWK 274 5,76083
7onsd 259 8,93927
7qHaU 262 6,50752
7qV4h 266 8,30554
7s0xE 246 9,41646
7ubuk 246 6,16290
7x2e4 239 6,49075
7xjnn 241 6,70083
7zBiG 286 6,71339
89wz5 269 5,71433
8clFh 270 5,71962
8fAnh 272 7,85878
8jCnj 270 5,62498
ug7F 246 9,29681
ugWm 255 6,38475
G9FH47 236 6,36554
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17457
7PxDe
 7 56,1% 178 8.689E-83
2 phalp2_32230
7h6JD
 19 46,2% 162 9.952E-60
3 phalp2_8504
1jszc
 7 41,1% 180 1.085E-54
4 phalp2_36825
6W23o
 94 33,4% 269 5.104E-51
5 phalp2_10392
1NTeW
 11 31,6% 250 3.338E-50
6 phalp2_24741
6EXtT
 52 39,2% 186 4.828E-45
7 phalp2_22201
6VaYI
 26 35,4% 172 5.629E-41
8 phalp2_26201
8INhm
 9 29,1% 192 1.050E-40
9 phalp2_31178
7Vvn5
 47 33,1% 208 7.289E-38
10 phalp2_16608
eqCG
 19 30,9% 242 4.400E-34

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 7cxQw (257 AA)
Member sequence: A0A5J6TSK3 (238 AA)
1 257 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Gordonia phage Schiebs
[NCBI] 		2599850 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN234213 [NCBI]
CDS location
range 3081 -> 3797
strand +
CDS
GTGACCCTCGGCCCCGTGACCGTGGACTGGCACCAGCGTTTTGATTTCGGCGGCCCGCGCCGGCACCCGATCCTCGGTATCTGTATCCACACCACCGAGAACGACCCCGGCACGCCGGCCGAGAACGTCGCCGGCTACCAGCTCCGCACCCGCTCCGGCTCGTATCACCGCCTGGTCGATGACGCCGGCCGGGTGCTGCTTGAGAACACCGACGACTGGACCACCTGGTCGAGTGGCAACCTCGGCAACGACGTGTTGCTGCACGTGGCCGTGGTGGCCCGCGCGAACATGACCCGCGCGCAGTGGCTCGCCCCCGAGCGTGCCCGCATGTTCGAGGCCCTGGCCCAGGTGGTCGCGTACTGGTGCCGTACCCACGGCATCCCGCCGGTGATCCTCGACGGCCCCGACCTGCTCAAGAACAAGCGCGGACTGTACGGCCATGACGACACGCGGATTTGGGGCGGTACCGACCACACCGACCCCGGCCCCGGTTTCCCGTGGCAGGCCCTCGCCGACCGCGTGACCGCGATCAACAACCCGAACACCCCGCCACCGCCGCCCGTAGGAGGCCCGACCATGACCGACGCCGATCGGCAAATGCTGCTTGAGATTTGGGACCAGCTACGCGGCCCCGGTGGCAACGGATGGCCCCAGCTCGGCGGCCGAACGCTGGTCGATGCCGTGGCCGAGCTGCTGCCCGAGGAGTCGGCCCGATGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7cxQw) rather than this protein.
PDB ID
7cxQw
Method AlphaFoldv2
Resolution 90.11
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50