Protein

Protein accession
A0A5J6T798 [UniProt]
Representative
7cTgF
Source
UniProt (cluster: phalp2_9283)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MADKILERGIDISRYQGNVDWKRVVKDNVKFVFMKATQGTNYTDPKLSANIKGSEAVGLENGLYHYATFRNKTEALAQARFFVSKAGKYKFERGLVLDLEENRGGLGRTALTEAALAFLDYINSKGHKAVLYINKNYYDNLLDMSRILPKYEVWIARYNSYLNVEGADYWQYTDKGKVDGIAGYVDLNYSLDDSTNEKAGSTTKPNKSKPSVSAGRAKNSDGTYTVRSGDTLSEIAADFGVKASDLQKWNGIKNANVISVGQKLKLKGSSSSPTSSTKTYTVKSGDSLSKIAAKYGTTVSNLQKLNGIKDPNFIKVGQKLKVSGSTSSSSQKTITVKSGDTVSELAAKHGTTKEKIRSWNKLDSNYTIYAGQKLRVK
Physico‐chemical
properties
protein length:377 AA
molecular weight:41466,3 Da
isoelectric point:9,67
hydropathy:-0,58
Representative Protein Details
Accession
7cTgF
Protein name
7cTgF
Sequence length
312 AA
Molecular weight
35283,88220 Da
Isoelectric point
9,49776
Sequence
MKGIDVSRWQGSIDWNKVKADGIEFVFVKATEGYGYVDPNFEQNVRGAYNAGLDVGAYHFARFESVNDAINEAKHFVNTVKDKPLNLPLVLDLETNEHGLSYAELTKAAETFLNYVRESTQFPVMVYTNKSFLSKFQKPSGVLLWYARYGVAKPDVDCDYWQYTDKGKVNGINGYVDMNLLMRSEHPAKVVKPTQKVEAVRQSKPQAKPTGDIYIVRSGDTLSEIAKKFNTTVSELVKFNNIKDPNKIYVGQKLRIRGSATVKSSPQYYVVQRGDTLSEIAVKFKTTVKKLQRLNGIKDPNKIYAGQKLRVK
Other Proteins in cluster: phalp2_9283
Total (incl. this protein): 101 Avg length: 328,3 Avg pI: 8,51
Protein ID Length (AA) pI
7cTgF 312 9,49776
13a6l 309 6,23327
1GC9r 345 9,38352
1IHDi 433 9,24891
1b4CD 309 9,37714
1d7ON 280 9,21661
1d9Zz 305 8,84166
1ded8 300 9,47319
1fRBH 384 5,53398
2G8tc 333 9,48074
2G8ww 388 9,27173
2S3pl 337 6,62006
2SgCd 338 6,25351
36ixV 324 4,49576
3MDo0 344 9,62289
4DXlt 286 8,50049
4EFd8 343 6,43175
4Ey6O 289 8,94649
4Ey78 300 9,25458
4Ey9w 314 8,77345
4M9yf 303 5,25774
4N1b8 320 8,31489
4Tv9i 348 6,84185
4cfBx 333 9,47107
4kTw5 433 9,19179
5tXlT 362 9,56164
6RCtb 311 6,92841
6S8x7 332 9,37082
6StUp 331 9,28443
6XgsO 294 5,68961
6Xi52 320 6,41186
72clI 289 9,53689
75HiO 322 9,22022
75RIA 314 9,20991
75n5g 316 9,47010
77kIo 310 9,07014
793rW 331 9,30023
79Mbd 276 9,39435
7bNKq 450 8,52177
7cDoR 315 9,10998
7cdLt 309 6,48478
7eqzO 280 9,25871
7gSPN 428 8,97176
7hC6b 306 8,47619
7hEl3 316 9,45534
7jV8Z 280 8,61389
7kXO2 316 9,33530
7kdiS 302 7,79218
7knmN 310 8,95906
7l91s 331 9,51890
7lwWW 280 9,28224
7lwWf 276 9,06073
7myOS 316 9,47010
7ofw6 308 6,54554
7ogfR 279 8,58411
7psXJ 426 9,24594
7qbUc 320 9,59040
7qbWj 318 9,50388
7rSof 380 5,85916
7re0V 311 8,92167
7sVtB 302 9,16897
7sVuN 285 9,23518
7vCWS 306 8,71479
7vCYr 301 7,80243
7vnPh 315 9,10998
7vo2c 315 9,22054
7vzD9 405 9,16536
7wNKD 313 9,01644
7wNil 391 8,11871
7wlfz 411 9,07568
7x2Qg 449 8,58675
7x51y 289 9,07033
7x52A 315 9,10991
7xQYa 449 8,33823
7xkGj 331 9,42284
7y5iF 311 6,91943
7yPIV 289 9,53689
7yPKy 316 9,45598
7yPMb 295 7,78116
7yYnE 311 7,76832
7yjvd 331 9,14157
7yyUC 311 8,47484
7yz2A 316 9,25813
7yza9 302 9,32956
7yzmi 289 9,18476
7zB7B 333 9,31241
7zBcZ 331 9,57525
7zBdy 276 9,28134
7zHR4 309 9,25781
7zHTS 319 7,76736
7zHVT 314 7,77406
8MX1U 394 9,67040
8m9DL 313 5,90929
8ma5P 370 4,65815
aK0V 287 8,93437
aKZQ 302 8,56509
c0It 335 8,93688
sDVs 349 9,60600
ts19 321 4,48627
A0A141HSE6 402 9,87857
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17042
7nSW4
 41 37,9% 324 1.577E-84
2 phalp2_22096
5ZSom
 2292 32,1% 355 5.377E-75
3 phalp2_26548
858CP
 728 36,3% 330 4.820E-74
4 phalp2_39912
1jXPT
 300 41,7% 206 8.669E-68
5 phalp2_5615
4g2xP
 40 36,7% 207 3.583E-55
6 phalp2_7683
6E7Ka
 26 31,4% 337 1.703E-54
7 phalp2_36883
7sfSC
 39 36,2% 232 1.703E-54
8 phalp2_30061
2NCcc
 23 34,6% 228 4.336E-54
9 phalp2_10110
c1k0
 16 31,9% 344 5.922E-54
10 phalp2_39679
5kP
 52 32,2% 338 1.104E-53

Domains

Domains [InterPro]
GH25
LysM
LysM
Representative sequence (used for alignment): 7cTgF (312 AA)
Member sequence: A0A5J6T798 (377 AA)
1 312 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01476

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacillus phage 035JT001
[NCBI] 		2601659 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN176226 [NCBI]
CDS location
range 28990 -> 30123
strand +
CDS
ATGGCTGATAAGATTCTGGAAAGAGGAATTGACATTTCACGCTACCAAGGGAATGTTGACTGGAAAAGAGTAGTGAAGGACAATGTTAAATTTGTATTCATGAAAGCAACACAAGGGACAAACTACACAGACCCTAAATTGTCTGCCAACATCAAAGGCAGTGAAGCGGTAGGTCTGGAAAATGGTTTATACCATTATGCAACATTCAGAAACAAAACTGAAGCGTTAGCCCAAGCAAGATTCTTTGTATCTAAAGCAGGGAAATATAAGTTTGAAAGAGGTCTTGTTCTCGATCTTGAAGAGAATAGGGGAGGGCTAGGAAGAACAGCCCTGACAGAAGCCGCCCTAGCATTCCTTGACTATATCAATAGTAAAGGACATAAAGCGGTATTGTACATCAATAAGAACTATTATGACAACCTTTTGGATATGTCCCGCATCCTTCCAAAATACGAAGTATGGATCGCTCGATACAACTCGTATTTGAATGTGGAAGGCGCAGACTATTGGCAGTACACGGATAAGGGTAAGGTAGACGGAATTGCGGGGTATGTAGACCTGAACTACTCACTGGACGATTCCACAAATGAGAAAGCGGGCAGTACCACGAAACCGAATAAATCAAAGCCTAGTGTTTCCGCAGGCAGGGCGAAGAATTCGGACGGCACTTACACAGTTCGTTCGGGTGACACTCTCAGTGAAATTGCGGCAGACTTTGGAGTCAAAGCATCAGACCTTCAAAAATGGAACGGTATTAAAAATGCAAATGTCATTTCCGTAGGTCAAAAACTGAAACTGAAAGGCTCTTCCTCTTCTCCTACATCCAGTACAAAGACATACACAGTGAAGAGTGGCGATTCCCTCAGTAAGATTGCGGCGAAGTATGGGACAACCGTTTCTAACCTTCAGAAATTGAATGGCATCAAAGACCCTAACTTCATCAAGGTAGGGCAAAAACTGAAGGTATCAGGTTCAACATCTTCTTCTAGTCAAAAGACAATCACTGTTAAATCAGGTGACACTGTGTCGGAGTTAGCTGCTAAACACGGAACGACAAAAGAAAAAATCCGATCTTGGAACAAGCTTGATTCAAATTACACAATCTATGCAGGGCAAAAATTGAGAGTTAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7cTgF) rather than this protein.
PDB ID
7cTgF
Method AlphaFoldv2
Resolution 86.54
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50