Protein

Protein accession
A0A5C1K728 [UniProt]
Representative
7y6FJ
Source
UniProt (cluster: phalp2_20987)
Protein name
Lysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVKVNDVVSYVNGLVGKGVDADGWYGTQCMDLTVDVMQRFFGWRPYGNAIALVDQPIPAGFQRIRTTSSTQIKAGDVMIWGLGYYAQYGHTGIATEDGRADGTFVSVDQNWINPSLEVGSPAAAIHHNMDGVWGVIRPPYEAAQKPAPTPKPKPESKPNLGQFKGDDDIMFIYYKKTKAGNTEQWFVIGGKRIYLPTMTYVNEANDLIKRYGGNTNVTTYNYDNFGLAMMEKAYPQVKL
Physico‐chemical
properties
protein length:239 AA
molecular weight:26524,8 Da
isoelectric point:6,83
hydropathy:-0,37
Representative Protein Details
Accession
7y6FJ
Protein name
7y6FJ
Sequence length
245 AA
Molecular weight
27700,87950 Da
Isoelectric point
7,01151
Sequence
MKKVIMMSDINKALSWLQQRQGKVSYSMNYRLGPSSYDCSSAVYNALIAGGFLPANTNIGNTETLFNDLERNGWQQVQPVNGNYPTKRGDVFIWGDRGFTLGAAGHTGMFIDDADNIIHCNYGYNGITVNDHDQIWNANGQPTITIYRQPRNGTTANISNSDEEPTKTMEKDDDIMFKFIKVQKNGSKEIWFVFGNKRMYLPTPKHVENADLLLKRTGHATKEEAYSHDNYALKMIEKATDIVKL
Other Proteins in cluster: phalp2_20987
Total (incl. this protein): 38 Avg length: 237,7 Avg pI: 6,55
Protein ID Length (AA) pI
7y6FJ 245 7,01151
G1C4Z3 237 6,41379
S5MRN1 237 6,41402
A0A0S2MXW6 238 6,82678
A0A411BIU2 237 6,41402
A0A4D6BKV8 238 6,82633
A0A4D6DSL8 237 6,41379
A0A4D6DT42 237 6,90039
A0A4Y5TMC4 239 7,72944
A0A510C2R4 237 6,41402
A0A6J4D3Z2 237 6,41402
S6CUC3 237 6,41391
A0A8E7KYG0 237 6,41402
A0A9E7DV91 238 6,07361
A0A9E7DVN0 239 6,82798
A0A9E7DVU0 237 6,29602
A0A9E7DVU3 237 6,41402
A0A9E7DW58 239 6,82798
A0A9E7DWB7 237 6,29613
A0A9E7J273 237 6,41402
A0A9E7J3R2 237 6,41402
A0A9E8YXD6 234 6,29005
A0AAE9V7W1 237 6,41635
A0AAE9V878 237 6,41635
A0AAE9VBJ8 237 6,41635
A0AAX3YUQ7 238 7,72348
A0AAX4J563 238 6,29244
A0AAX4JHA1 238 6,29244
A0AAX4JHI6 238 6,29244
A0AAX4JIC4 238 6,29244
A0AAX4JIK7 238 6,29244
A0AAX4JJH4 238 6,29244
A0AAX4JJY1 238 6,29244
A0AAX4M443 239 7,76497
A0AAX4PRM9 238 6,29005
A0AAX4PS96 237 6,41379
A0AB39C679 237 6,29613
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_632
1csV3
 60 45,6% 182 6.608E-38
2 phalp2_9275
76k47
 345 43,7% 199 1.321E-35
3 phalp2_13886
7C1QD
 360 40,1% 172 1.148E-29
4 phalp2_12594
1nLjj
 56 37,8% 161 1.148E-15
5 phalp2_28643
7orrE
 9 33,1% 178 2.127E-12

Domains

Domains [InterPro]
Ami5
Unannotated
Representative sequence (used for alignment): 7y6FJ (245 AA)
Member sequence: A0A5C1K728 (239 AA)
1 245 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF05382

Taxonomy

  Name Taxonomy ID Lineage
Phage Enterococcus phage vB_EfaS_EF1c55
[NCBI] 		2601631 Saphexavirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN103542 [NCBI]
CDS location
range 28500 -> 29219
strand -
CDS
ATGGTTAAAGTAAACGATGTAGTAAGCTATGTCAACGGACTTGTCGGCAAAGGCGTGGACGCTGACGGATGGTATGGTACTCAATGTATGGACTTGACAGTAGACGTTATGCAACGCTTCTTCGGATGGCGTCCGTATGGTAATGCGATTGCCTTGGTTGACCAGCCTATTCCAGCAGGCTTCCAAAGAATCCGTACCACAAGCTCTACACAAATCAAAGCTGGTGACGTTATGATATGGGGCTTAGGATACTATGCTCAATATGGTCACACAGGAATTGCAACGGAGGACGGAAGAGCTGACGGAACCTTTGTCAGTGTCGACCAGAACTGGATTAACCCAAGCCTTGAAGTAGGCAGTCCAGCAGCTGCTATCCACCACAATATGGATGGTGTCTGGGGAGTTATCCGACCACCTTATGAAGCGGCGCAAAAGCCTGCTCCAACACCTAAACCAAAGCCTGAAAGTAAACCAAATCTAGGACAATTTAAAGGAGACGATGACATTATGTTTATTTACTACAAGAAGACTAAAGCAGGTAACACTGAGCAATGGTTCGTAATCGGAGGCAAACGTATCTACCTTCCAACAATGACTTATGTAAACGAGGCTAACGACCTTATCAAACGCTACGGTGGAAACACTAATGTAACAACCTATAACTATGATAACTTTGGATTGGCAATGATGGAGAAAGCTTACCCACAAGTTAAGTTATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. N/A UniProt

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7y6FJ) rather than this protein.
PDB ID
7y6FJ
Method AlphaFoldv2
Resolution 85.42
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50