Protein

Protein accession
A0A5B9N9E5 [UniProt]
Representative
8n5Jv
Source
UniProt (cluster: phalp2_6830)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MDNVALPPVHLNLSPAGMEFIMKHEGMRTKAYKDSAGIWTICVGATRDMNGYPVRQGLTYSIEDCLALLDRDTQDSVRATQKNIKVPLLIHEFDALTSFNFNVGSGALSTSKLRKVINGEVKGDVYSEFLRWDKITVKGEKQRSQGLHNRRVAEADLYTEGKY
Physico‐chemical
properties
protein length:163 AA
molecular weight:18280,7 Da
isoelectric point:8,50
hydropathy:-0,41
Representative Protein Details
Accession
8n5Jv
Protein name
8n5Jv
Sequence length
231 AA
Molecular weight
25138,35430 Da
Isoelectric point
9,61818
Sequence
MVKNVSFGDKGEDVKSLQTKLKDLGYLTGGADGIFGQATKLALIKFQKNEGLVADGIAGSRTLSKLEDSNPIKPNKTEKVISQKGINFIQSFEGYSSKAYDDGVGVWTIGWGTTIKPNGQKVKKGDVATKDQSLEYFKHDLKSFELAVNRLVKVNINQDQYDALVSFTYNVGIGALTGSTALRKINQGDLKGGADAMLSWNKGTVNGKKVELKGLTRRRNAERNLFLSISI
Other Proteins in cluster: phalp2_6830
Total (incl. this protein): 121 Avg length: 178,2 Avg pI: 8,36
Protein ID Length (AA) pI
8n5Jv 231 9,61818
1QWnu 186 9,77052
1b5QB 190 4,26948
1f6mo 206 9,11733
1hsZ4 148 5,28963
1nH5j 195 4,32996
1pfFi 183 8,80137
1qU5T 141 9,09625
2DJjA 148 5,47754
2ElJ5 148 5,04272
2RfsT 187 5,29526
2SRHQ 218 5,12235
2SviH 188 4,25891
2XUNV 189 4,33451
2XVvs 189 4,30063
2bCss 148 4,81446
2seQM 185 9,32724
2shnS 185 9,47726
2snDr 184 9,13532
2snHu 185 9,17129
2snss 184 8,86874
2soWL 185 9,17110
3MSMA 149 9,09541
3WIbJ 141 10,13387
3rkpa 142 9,26844
47chf 148 5,89497
4HIc5 191 4,52100
4HJhr 176 4,24931
4HP2k 189 4,50969
4HUHn 191 4,56311
4IfhL 190 4,51366
4Kwv8 263 5,58724
4MRc9 254 6,13988
4RC2w 180 9,51336
4TFtY 180 9,26844
4d2lG 148 5,04272
5TbCv 141 9,78696
5l7GC 242 5,24672
5zJXW 185 8,89788
60bwQ 142 8,99432
60h96 115 8,24533
6IlWf 141 5,26002
6Q9AN 154 9,77407
6VSvN 197 9,58840
6VyzR 258 6,43772
6epID 142 8,67682
6iIP6 142 9,10863
72aB5 186 9,66944
7BVVa 148 9,29984
7ZRu1 183 9,50749
7xE45 184 8,84198
81nCt 166 7,69159
82thB 219 9,60884
84ubM 223 9,92583
87Sg4 145 9,72855
8DemR 178 8,59365
8Hj2O 224 9,60742
8iSOw 183 9,48061
8mpu6 219 9,52122
8psVB 146 9,66563
8yzo8 171 9,35309
bZIL 198 9,63153
dCBi 184 9,78806
dGjE 184 9,06085
eaWX 186 9,35934
fuUk 280 9,03391
gHMU 181 9,71495
gIWq 186 9,53579
gQG 224 9,45991
jIfP 144 9,06782
mvrl 148 6,06912
A0A7G9VXR9 188 9,51877
A0A6B9LPY4 188 9,58150
J9SV49 163 7,77581
W6ARR9 163 8,51545
I3WVU6 190 9,19424
A0A7T0LW97 163 8,84792
A0A0D5BI97 163 8,86571
A0A0B4N1I9 163 8,51681
A0A2I6PD01 163 7,77452
A0A1J0MH64 224 9,60742
E5E3Z4 190 9,31976
A0A6B9SSJ9 188 9,42516
A0A2Z3DM40 163 8,51539
A0A345AUK2 188 9,42516
A0A482MTD5 163 8,84779
A0A5C1K9H6 163 8,51681
A0A5P8D4L0 155 9,47603
A0A5P8D625 155 9,47603
A0A650EUI7 188 9,51877
A0A678ZJR2 155 9,62502
A0A678ZN30 155 9,62502
A0A6B9J4K1 188 9,42516
A0A6J4EF85 163 8,86571
A0A6J4EFW7 163 8,51687
A0A6M9EFW9 163 8,84792
A0A6M9Z6K4 188 9,51877
A0A7L4XVV0 163 8,84792
A0A7T7GRI3 187 9,31860
A0A7T8EZV2 187 9,31860
A0A7T8F0J3 187 9,31860
A0A7T8F118 187 9,31860
A0A7U3VGB2 187 9,31860
B0FIH9 163 8,50249
A0A0A0RR05 224 9,45991
A0A3T0IGR7 187 9,31860
A0A6G5YKU5 148 9,12532
A0A8F3C9B7 163 9,27263
A0A9E7DQN7 188 9,42516
A0A9E7SIN1 163 9,27263
A0AA96J2M1 163 8,50249
A0AAE7WE23 163 9,27263
A0AAE7XSR4 163 9,27263
A0AAE8Y2S9 163 8,50385
A0AAE8YC47 163 9,27263
A0AAU6NTT3 163 8,50249
A0AAU6NU60 163 8,50249
A0AAV2PGR2 187 9,33846
A0AAX3Y020 191 9,39467
A0AAX4RGI7 156 9,54508
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28113
7zmZV
 50 53,0% 149 2.032E-67
2 phalp2_2632
6RhYr
 14867 51,0% 149 5.277E-64
3 phalp2_33221
5jbqV
 447 48,0% 150 2.295E-62
4 phalp2_4451
31DIk
 4919 51,6% 151 1.366E-60
5 phalp2_2498
5GMvl
 297 47,6% 149 6.575E-60
6 phalp2_17663
6R9yG
 6 42,7% 213 1.003E-57
7 phalp2_26378
1q5mp
 207 47,3% 150 4.824E-57
8 phalp2_30676
6Q25R
 25 47,2% 146 9.041E-57
9 phalp2_32792
2snIK
 45 42,8% 147 3.176E-56
10 phalp2_34911
4lF8s
 21 45,9% 161 5.952E-56

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 8n5Jv (231 AA)
Member sequence: A0A5B9N9E5 (163 AA)
1 231 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959|PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Escherichia phage Paul
[NCBI] 		2589659 Kuravirus > Kuravirus paul
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN045231 [NCBI]
CDS location
range 16797 -> 17288
strand +
CDS
ATGGATAACGTCGCATTGCCACCTGTACATCTAAACTTAAGCCCAGCTGGAATGGAATTCATCATGAAGCATGAAGGTATGAGAACCAAGGCTTATAAAGATTCCGCAGGTATCTGGACGATATGTGTAGGGGCTACGCGCGATATGAATGGTTATCCGGTTAGGCAAGGATTAACATATTCTATAGAGGATTGTCTAGCTCTGCTAGATAGAGACACACAAGACTCTGTTCGTGCTACTCAGAAAAACATAAAGGTTCCTTTGCTTATTCATGAGTTCGATGCACTCACCTCTTTCAACTTCAATGTTGGTAGTGGGGCACTGAGCACGTCTAAGTTAAGGAAGGTTATCAATGGAGAAGTCAAAGGTGATGTATACTCGGAGTTTCTTCGTTGGGATAAAATTACGGTGAAGGGAGAGAAGCAGAGGAGTCAGGGTCTTCATAACAGAAGGGTTGCAGAAGCTGATCTTTATACCGAAGGTAAATATTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0020002 host cell plasma membrane cellular component None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8n5Jv) rather than this protein.
PDB ID
8n5Jv
Method AlphaFoldv2
Resolution 93.76
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50