Protein

Protein accession
A0A513ZZ78 [UniProt]
Representative
7iQxx
Source
UniProt (cluster: phalp2_15045)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSTIQKSVVGCSVAAALGLVASLFPNELRTSTEGLALIGKWESCTLTAYRDIVQVPTIGIGSTKGVCMGQVIDLKEVAYRFKEDVKEAEQCVDRWFNGKRMPGHVFDATVSLVYNNGCYGTRWNRKANRATQIASYASQQNWDRVCYHLGDFINAGGKPSKGLINRRAGEQAWCLTGVRY
Physico‐chemical
properties
protein length:180 AA
molecular weight:19848,5 Da
isoelectric point:9,12
hydropathy:-0,20
Representative Protein Details
Accession
7iQxx
Protein name
7iQxx
Sequence length
207 AA
Molecular weight
22478,14910 Da
Isoelectric point
9,09393
Sequence
MLLSKFGGIFRTIFEAFSRPGLSTGSELRSSSGESSASSMSSKSSLNQERKLRTGAAGLSLIKHYEGCRLEAYQDIVGIWTIGYGDTENVQPGLVITQEEAEERLRNRLERDFEPSLRQSLTLVATQCQFDAIACLAYNIGAAAFASSTLVRLFNAGDVQLAADQFLRWDKAGGKSIKGLRRRRAAERALFLGASVTSAISTGEKTP
Other Proteins in cluster: phalp2_15045
Total (incl. this protein): 18 Avg length: 183,6 Avg pI: 9,30
Protein ID Length (AA) pI
7iQxx 207 9,09393
11ih1 227 10,46343
1LsX2 150 9,64797
1bbJl 150 8,96647
1jVmC 143 9,22583
2prnd 164 8,89188
36kNn 170 9,02836
3eyMO 199 9,40821
3ezc1 199 9,16723
6AMTK 200 9,70767
7fkqA 235 9,78851
A0A1S5Q8G1 180 9,35296
A0A513ZYZ8 180 9,12410
A0A513ZZ84 180 9,12410
A0A513ZZD8 180 9,12410
A0A513ZZK6 180 9,12410
A0AA96ESY7 180 9,00625
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28113
7zmZV
 50 47,5% 160 2.192E-59
2 phalp2_2632
6RhYr
 14867 55,9% 143 4.614E-57
3 phalp2_33221
5jbqV
 447 56,6% 143 8.771E-54
4 phalp2_4451
31DIk
 4919 46,2% 147 7.928E-53
5 phalp2_2498
5GMvl
 297 53,6% 149 7.928E-53
6 phalp2_6830
8n5Jv
 121 47,0% 170 1.840E-51
7 phalp2_126
5jCCA
 637 45,2% 146 1.222E-47
8 phalp2_4532
3QBcV
 9 46,4% 168 1.673E-47
9 phalp2_34911
4lF8s
 21 42,3% 151 8.050E-47
10 phalp2_32792
2snIK
 45 46,9% 149 7.258E-46

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 7iQxx (207 AA)
Member sequence: A0A513ZZ78 (180 AA)
1 207 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Aeromonas phage LAh2
[NCBI] 		2591026 Autographiviridae > Ahphunavirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK838108 [NCBI]
CDS location
range 18469 -> 19011
strand +
CDS
ATGTCCACCATCCAGAAATCGGTGGTGGGCTGCTCAGTGGCAGCAGCTCTCGGCCTAGTGGCCAGCCTCTTTCCGAACGAGCTACGCACCTCCACGGAGGGCCTAGCTCTTATCGGCAAGTGGGAGAGCTGCACACTGACAGCCTACCGCGACATCGTGCAGGTCCCCACTATAGGCATCGGCTCTACCAAGGGCGTGTGCATGGGACAGGTCATCGACCTCAAGGAGGTGGCCTACCGGTTCAAGGAAGACGTGAAGGAAGCCGAGCAGTGCGTGGACCGGTGGTTCAACGGGAAGCGTATGCCGGGCCATGTGTTCGACGCTACGGTGTCACTCGTCTACAACAACGGCTGCTACGGCACCCGCTGGAACCGAAAGGCCAACCGGGCCACACAGATTGCAAGCTACGCCTCCCAGCAGAACTGGGACCGGGTATGCTACCATCTGGGTGACTTCATCAATGCCGGCGGTAAGCCTAGCAAGGGCCTTATCAACCGGCGAGCAGGAGAGCAAGCATGGTGCTTGACTGGCGTGCGCTACTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7iQxx) rather than this protein.
PDB ID
7iQxx
Method AlphaFoldv2
Resolution 82.85
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50