Protein

Protein accession
A0A4Y6EPW3 [UniProt]
Representative
7fr21
Source
UniProt (cluster: phalp2_26063)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MPYSARALGYARRVAAVGKGLGITARGIKIAFATMIVETAINDADGNLTLRNLANSKVPASLKIPNDGIGSDGYSVGVFQQQVRQGNGGEWWWGDAATCMNIESSARLFFTRLAKLNYNGSGSPGSYAQAVQGSAYPDRYDQRFAEATALYDLVAGDVPATTPPTGGSNVAIDYGITHTIYGYNAGSAGTGNSNGNRSRTDFAAVHTQEGGNGDAIGLANYANGAEVAYNIEVDDEHTVLNVPVTEGPWAAADANNVAFHLCFAGSYAAWSASRWLSKDASDGLDEDAMLWRGARAVAAACQQFGIPVKRVGATSYAAGNWPSERGICGHVAFGSRGGGHYDPGTGFPWAEFIRRVQTFFATAPAPINLIEAEAKVAASWIGKRLAVAGQAGETAILKAGTKTKIGAFVEYENAHVYWRVGANAAYAIPHGGLFEAYAARKWEAGPLGFPIMRHTVETAHGVTGGVQAFQGGTLMTPTGGPAAGFWLHGEIGKAYAAQKWEQGALGWPKSDEYAAPEFGVGAIRQDFAGASLIWTPSGVVTITN
Physico‐chemical
properties
protein length:544 AA
molecular weight:57064,9 Da
isoelectric point:6,14
hydropathy:-0,13
Representative Protein Details
Accession
7fr21
Protein name
7fr21
Sequence length
402 AA
Molecular weight
43791,10610 Da
Isoelectric point
5,46469
Sequence
VTTKDQVAQLIVAEAKQRGHTRDECLAEMSALYQESGWVETIWDSTHTTYGVAQQDDSYPNRFGGAAPQIKAFFDKLDTKRTSPGHGDIWLNICWLQQAPNWPSAQYWYEHGRREYLTEIKSRIATVTPYLDKYWPTNGGNNVPATQFDYGITDVLHGFNPNTPDNATGNSNGPRAQTLYVVVHTQQARASAIDLATFCNNSRITQPDNPVSYNLAVDDKHTVEIVPVTEGPWAAADANSIAVHICFAGSFAEWSEGKWLETDASDGLNEDAMLTRGAKAAAAACQQFGLPAVYAGDGGKSGWPILPKGIVGHRDFGRRGGGHTDPGDGFPMDAFIRRVKAFMTPVSNPPVDPQHPSGPVGPADEQLTLRWKQLGGQTLVEAVAEIRDKVLGTNDRGKTGAL
Other Proteins in cluster: phalp2_26063
Total (incl. this protein): 22 Avg length: 507,1 Avg pI: 6,20
Protein ID Length (AA) pI
7fr21 402 5,46469
76rdp 397 5,15361
86WWV 414 5,66085
A0A514DGU3 455 6,87720
A0A649VNE7 537 6,22833
A0A649VN79 537 6,22833
A0A7T1KS33 543 6,02422
A0A0K0MX08 544 6,27607
A0A411CSE5 544 6,42749
A0A649VUF2 538 6,19809
A0A7L7SSM3 587 6,19746
A0A4D6T7N7 582 6,20400
A0A2Z4Q613 527 7,11950
A0A385DN10 537 6,22975
A0A411BVZ6 352 6,52974
A0A7L7SL96 352 6,67082
A0A7L8ZDI4 544 6,14335
A0A9E7NHR6 602 5,84660
A0A9E7NKH4 537 6,17456
A0AA96QXM2 544 6,42749
A0AAE7VCQ5 537 6,22975
Similar Clusters

No similar clusters were found for representative 7fr21.

Domains

Domains [InterPro]
Unannotated
Ami2
Unannotated
Representative sequence (used for alignment): 7fr21 (402 AA)
Member sequence: A0A4Y6EPW3 (544 AA)
1 402 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Gordonia Terrae phage RoadKill
[NCBI] 		2588506 Dexdertvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK977704 [NCBI]
CDS location
range 33414 -> 35048
strand +
CDS
ATGCCTTACTCAGCGAGAGCACTCGGATATGCACGGCGCGTCGCCGCCGTCGGCAAGGGCCTCGGCATCACAGCCCGAGGTATCAAGATCGCGTTCGCGACGATGATCGTCGAGACCGCTATCAACGACGCAGACGGCAACCTGACGTTGCGCAACCTCGCGAACTCGAAGGTGCCGGCATCGCTGAAAATCCCGAACGACGGCATCGGCTCGGACGGGTACAGCGTCGGCGTGTTTCAGCAGCAGGTTCGGCAGGGCAACGGCGGCGAATGGTGGTGGGGCGACGCCGCGACGTGCATGAACATCGAGTCGTCGGCCCGGCTGTTCTTCACCCGGCTCGCGAAACTGAACTACAACGGCTCGGGCTCGCCGGGCAGCTACGCGCAGGCCGTGCAGGGCAGCGCGTACCCCGACCGGTACGACCAGCGGTTCGCCGAGGCGACCGCGCTCTATGACCTCGTGGCCGGCGACGTGCCGGCGACGACCCCACCGACAGGAGGCTCGAACGTGGCGATCGACTACGGCATCACACACACGATCTACGGGTACAACGCCGGCAGCGCCGGCACCGGCAACTCGAACGGCAACCGGTCGCGCACCGACTTCGCCGCGGTCCACACGCAGGAGGGCGGCAACGGCGACGCGATCGGGCTCGCGAACTACGCCAACGGCGCCGAGGTCGCCTACAACATCGAGGTCGACGACGAGCACACGGTGCTGAACGTGCCGGTCACCGAAGGGCCTTGGGCTGCAGCGGACGCGAACAACGTCGCGTTTCACCTGTGTTTCGCCGGCAGCTATGCGGCGTGGTCGGCGTCGCGCTGGCTGTCGAAGGACGCGAGCGACGGGCTCGACGAGGATGCGATGCTGTGGCGCGGTGCTCGCGCGGTAGCGGCCGCGTGTCAGCAGTTCGGTATCCCGGTCAAGCGCGTCGGCGCCACCAGCTACGCGGCCGGCAACTGGCCGAGCGAGCGCGGGATCTGTGGGCACGTCGCGTTCGGTTCGCGCGGCGGCGGCCACTACGACCCCGGTACCGGGTTCCCCTGGGCCGAGTTCATTCGCCGAGTGCAGACGTTTTTCGCGACGGCGCCGGCACCGATCAACCTGATCGAGGCCGAGGCGAAGGTCGCCGCGTCGTGGATCGGCAAGCGGCTCGCCGTCGCAGGGCAGGCCGGCGAAACGGCGATTCTGAAAGCCGGCACCAAGACCAAGATCGGCGCGTTCGTCGAGTACGAGAACGCTCATGTGTACTGGCGAGTCGGCGCGAACGCTGCCTACGCGATCCCTCACGGCGGGCTGTTCGAGGCGTACGCCGCGCGCAAGTGGGAGGCCGGCCCGCTCGGGTTCCCGATCATGCGGCACACCGTCGAGACCGCTCACGGCGTGACCGGCGGCGTGCAGGCATTCCAGGGCGGCACACTCATGACCCCGACCGGCGGGCCGGCCGCCGGGTTCTGGCTGCACGGCGAGATCGGTAAGGCGTACGCCGCGCAGAAGTGGGAGCAGGGCGCGCTCGGCTGGCCGAAGTCGGACGAGTACGCCGCACCCGAGTTCGGCGTCGGGGCGATCCGGCAGGACTTCGCCGGCGCCTCGCTCATTTGGACGCCAAGCGGCGTCGTCACGATCACCAACTAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7fr21) rather than this protein.
PDB ID
7fr21
Method AlphaFoldv2
Resolution 87.54
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50