Protein

Protein accession
A0A4Y1NTU6 [UniProt]
Representative
8EJ62
Source
UniProt (cluster: phalp2_30823)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MYTQLKERIKQHEGFRRSIYSDSLGFATIGYGHLVLPTDNFVEGVEYTKEELDAVFDNDFQIALTSAQELLEEIEVPETVLGVIVEMCFQLGKPRVMKFKKMWAAIEQQDWNTAANEMIDSAWHKQTTSRCEELAETMRSA
Physico‐chemical
properties
protein length:141 AA
molecular weight:16244,2 Da
isoelectric point:4,73
hydropathy:-0,36
Representative Protein Details
Accession
8EJ62
Protein name
8EJ62
Sequence length
221 AA
Molecular weight
N/A Da
Isoelectric point
5,76389
Sequence
mdietlkdhikkeegfrnkvyldhlgnrtigyghlclpdenwdddkvydskeldktfeydfniackdaekliaresihpdafcvlidmcfnmgsprvskfkkmfaaletqdyqtaskemldskwanqvpnrarrlseimexxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxggkmnlikdlwnhlkewndwgmkdwikagivvvvvlvilkviiipga
Other Proteins in cluster: phalp2_30823
Total (incl. this protein): 2 Avg length: 181,0 Avg pI: 5,25
Protein ID Length (AA) pI
8EJ62 221 5,76389
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_21661
31ima
 875 47,4% 139 6.718E-46
2 phalp2_37538
3rBoT
 1 46,8% 141 5.721E-36
3 phalp2_12412
8GwzA
 1 51,4% 177 5.102E-35
4 phalp2_27968
RI1z
 5083 54,4% 134 6.210E-34
5 phalp2_2924
QDRo
 8927 41,9% 143 8.129E-31
6 phalp2_19234
42usC
 219 43,8% 146 7.202E-30
7 phalp2_35438
8DSMF
 6 30,2% 185 4.961E-27
8 phalp2_33457
7eghX
 14 43,0% 137 1.720E-26
9 phalp2_17008
8jNgs
 3526 45,7% 142 2.346E-26
10 phalp2_9780
80F6A
 154 43,4% 138 4.367E-26

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 8EJ62 (221 AA)
Member sequence: A0A4Y1NTU6 (141 AA)
1 221 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pelagibacter phage HTVC200P
[NCBI] 		2283023 Autographiviridae > Votkovvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH598801 [NCBI]
CDS location
range 37704 -> 38129
strand +
CDS
ATGTATACGCAACTTAAAGAAAGAATTAAACAACACGAAGGCTTTAGGCGTTCTATCTATTCCGATAGTTTGGGTTTTGCTACTATCGGTTATGGCCATTTGGTATTACCTACCGATAACTTTGTTGAAGGTGTTGAGTATACTAAAGAAGAGCTTGATGCTGTTTTTGACAACGATTTTCAAATTGCTCTTACATCTGCGCAAGAATTACTTGAAGAAATAGAAGTACCAGAAACTGTGCTTGGTGTAATTGTAGAAATGTGCTTTCAGCTCGGCAAACCAAGAGTTATGAAATTTAAAAAAATGTGGGCTGCTATAGAACAACAAGACTGGAATACAGCAGCTAACGAAATGATTGACAGCGCTTGGCATAAACAAACTACTTCAAGATGCGAAGAGTTAGCAGAAACTATGAGGAGTGCATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8EJ62) rather than this protein.
PDB ID
8EJ62
Method AlphaFoldv2
Resolution 75.47
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50