Protein

Protein accession
A0A4D6ADD3 [UniProt]
Representative
6Z1Os
Source
UniProt (cluster: phalp2_36839)
Protein name
Lysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVEIINHTIFNGISGSRPTERPKYYVLHNDAGSKSAKAYIEWLQERYDNGQSELGFAHYYITRDAIVRVEDTYNGSWSAANYDANMNSLSYEVCQQYNSTDAEFIENENMVLRQMAEDMTYYGDTPNYSNIKFHNEFSSTSCPARSLELHGGYNDSLRDYVISKIKHYQSLGSTVQEMLDNEGTQEGWKKNATGWWYVNADGSYPTNKWQKIDNFWYYFDSNGYMKANYWHKHTDGYWYYLLPSGDMATGWALIANKWYYFKETGAMATGWVKYKDHWFYLDAKDGDMKSKQFIKSADGSGWYYLKEDGTMADKPEFTVEPNGLITTK
Physico‐chemical
properties
protein length:328 AA
molecular weight:38196,7 Da
isoelectric point:5,22
hydropathy:-0,80
Representative Protein Details
Accession
6Z1Os
Protein name
6Z1Os
Sequence length
183 AA
Molecular weight
20793,64460 Da
Isoelectric point
4,91733
Sequence
MVKIINNTIFNGIAGSRSTEKPKYYIMHNDAGSMSAESYVNWLQSRYDNGQSELGFAHYYITRDAIARVEDTYNGTWSAANYDANMNSLSYEVCQQLSASDAEFIENENMVLRQMAEDMTYYGDTPNYSNIKFHNEFSSTSCPARSLKLHGGYNDSLRDYVIAKIKHYQSLGSTVQEMLDNEG
Other Proteins in cluster: phalp2_36839
Total (incl. this protein): 11 Avg length: 291,9 Avg pI: 4,69
Protein ID Length (AA) pI
6Z1Os 183 4,91733
5JZaU 326 4,55578
5KS9Q 326 4,48536
5OmR8 225 4,97054
5PRvE 325 4,46473
6a0jv 260 4,47103
6hJie 260 4,50150
70Ji2 326 4,55123
oVSh 326 4,49496
A0A8S5R071 326 4,93848
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_15359
1El58
 3 46,8% 173 7.874E-44
2 phalp2_35500
DDEb
 68 34,1% 173 6.560E-36
3 phalp2_15488
8diNj
 63 43,1% 160 1.230E-32
4 phalp2_36896
7vCZc
 30 36,6% 172 5.909E-32
5 phalp2_8333
8JaN1
 18 30,5% 121 1.996E-07
6 phalp2_25038
13C0m
 57 24,4% 135 3.306E-05
7 phalp2_19721
4Mjrh
 7 26,3% 148 1.468E-04

Domains

Domains [InterPro]
Ami2
Representative sequence (used for alignment): 6Z1Os (183 AA)
Member sequence: A0A4D6ADD3 (328 AA)
1 183 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptococcus phage Javan367
[NCBI] 		2548128 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK448740 [NCBI]
CDS location
range 38619 -> 39605
strand +
CDS
ATGGTAGAAATCATTAACCATACAATCTTCAATGGGATTTCAGGCTCACGTCCAACTGAACGTCCGAAATATTATGTCTTACATAATGATGCTGGTTCAAAAAGTGCAAAGGCCTATATCGAATGGCTTCAAGAACGATATGACAATGGGCAGTCTGAACTTGGTTTTGCTCATTACTACATCACAAGAGATGCAATTGTGCGAGTCGAAGACACATACAATGGTTCGTGGTCTGCAGCGAACTATGATGCGAACATGAACTCTCTTAGCTACGAAGTATGTCAACAATACAACTCAACAGATGCCGAGTTCATTGAAAATGAAAACATGGTATTGCGTCAAATGGCTGAGGATATGACCTATTATGGTGATACTCCGAACTATTCAAATATTAAGTTCCATAACGAATTTTCAAGCACATCTTGCCCTGCTCGTTCCCTTGAATTGCACGGCGGCTACAATGACAGCCTGCGTGACTACGTGATTTCTAAGATTAAGCATTATCAGTCGCTCGGTTCAACTGTTCAAGAAATGCTCGATAATGAGGGCACCCAGGAAGGCTGGAAGAAAAATGCGACTGGTTGGTGGTATGTCAACGCAGATGGAAGTTACCCAACGAATAAATGGCAGAAGATTGACAATTTCTGGTATTACTTTGACAGTAACGGCTATATGAAAGCTAACTATTGGCACAAACACACAGACGGCTACTGGTACTACTTGCTCCCAAGTGGAGACATGGCTACTGGTTGGGCGCTTATTGCTAACAAGTGGTACTACTTCAAAGAAACTGGTGCCATGGCCACTGGATGGGTTAAATATAAAGACCACTGGTTCTACCTCGATGCCAAAGACGGTGATATGAAATCCAAACAGTTCATTAAGTCAGCCGACGGATCAGGCTGGTACTACCTAAAAGAAGATGGCACAATGGCAGATAAGCCAGAGTTCACAGTCGAGCCTAATGGCTTGATCACTACTAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. N/A UniProt

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6Z1Os) rather than this protein.
PDB ID
6Z1Os
Method AlphaFoldv2
Resolution 97.81
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50