Protein

Protein accession
A0A4D6A5S9 [UniProt]
Representative
5JYK7
Source
UniProt (cluster: phalp2_23379)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 95% (predicted by ML model)
Protein sequence
MTTVNEALNDLSALVYSGTPVGNGECYALASYYESLINPDGTVGLGAGVGYVSGAIGDTICAANIGTSYDWSANGWSVSSDDELQPGQILTIQANAYNEYGHVVVVEAVDGDQLTVIEQNYAGARYPVRNYYSASEYQQTVAHYITPPGAETTESASDTNTSTTSTEPNSYKEDGTMTVTVDAINVRRSPDTSGEVVAQYTKGQSFKYDTVIIDYNGFVWVSYVGASGNRNYVATGPTQNGKRFGDAWGTFK
Physico‐chemical
properties
protein length:252 AA
molecular weight:26896,8 Da
isoelectric point:4,18
hydropathy:-0,34
Representative Protein Details
Accession
5JYK7
Protein name
5JYK7
Sequence length
133 AA
Molecular weight
14491,55060 Da
Isoelectric point
5,01447
Sequence
VIEQNYAGARYPVRNYYSASDYIQTVAHFITPEQSDGETAGETTSVSDSSQYAENGTMTVTVDAINVRRSPDTSGEVVDQYAKGQSFKYDTVIVDANGFVWVSYIGGSGKRNYIATGPTQNGKRYGAAWGTFK
Other Proteins in cluster: phalp2_23379
Total (incl. this protein): 2 Avg length: 192,5 Avg pI: 4,60
Protein ID Length (AA) pI
5JYK7 133 5,01447
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_7974
NzwP
 4 37,0% 124 3.921E-13
2 phalp2_33308
6gvLj
 1 40,4% 84 4.820E-12
3 phalp2_34144
2lNi2
 9 36,2% 91 2.516E-09

Domains

Domains [InterPro]
Disordered region
Unannotated
Representative sequence (used for alignment): 5JYK7 (133 AA)
Member sequence: A0A4D6A5S9 (252 AA)
1 133 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptococcus phage Javan241
[NCBI] 		2548065 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK448714 [NCBI]
CDS location
range 35744 -> 36502
strand +
CDS
ATGACAACAGTAAACGAAGCATTAAACGATTTATCAGCTCTTGTGTACTCAGGTACACCTGTCGGCAATGGCGAGTGCTATGCACTAGCAAGCTACTATGAATCTCTTATTAATCCAGATGGTACAGTTGGATTAGGTGCTGGTGTCGGATATGTCAGTGGCGCAATCGGAGATACAATTTGCGCAGCTAATATCGGTACCAGCTACGATTGGAGCGCTAATGGATGGTCTGTATCTAGTGATGATGAATTACAACCAGGACAAATTTTAACTATCCAAGCCAATGCCTATAACGAGTATGGACACGTTGTTGTTGTTGAAGCTGTGGATGGAGATCAATTAACAGTCATTGAGCAAAATTATGCTGGCGCTCGCTACCCTGTGCGCAACTATTACAGCGCATCCGAATATCAACAAACTGTAGCTCATTACATCACCCCTCCTGGTGCAGAAACAACAGAAAGTGCGTCTGACACTAATACATCAACTACATCAACTGAACCAAACAGTTACAAAGAAGACGGTACAATGACCGTCACAGTAGATGCTATCAATGTACGACGCTCTCCTGACACATCTGGAGAAGTGGTTGCCCAGTATACAAAAGGGCAAAGTTTCAAGTATGATACCGTGATCATTGATTACAATGGTTTTGTATGGGTGTCTTACGTTGGAGCAAGTGGAAATCGAAATTATGTTGCAACAGGGCCTACTCAAAACGGCAAACGTTTTGGAGACGCTTGGGGTACATTTAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0003824 catalytic activity molecular function None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5JYK7) rather than this protein.
PDB ID
5JYK7
Method AlphaFoldv2
Resolution 68.77
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50