Protein

Protein accession
A0A4D5ZZQ8 [UniProt]
Representative
7ocj2
Source
UniProt (cluster: phalp2_25333)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MQCADLPCFIVKNWFGIDLWGNAIDLLNSASAQGLEVIYNAPGVNPKASDLFVMEVAGSPYGHTGAVIEDSDGYTIKTVEQNIDGNWDSLQVGGPARFNTRDFTGVVGWIRLPVDHTNQTVDTAPQTSDTIVETSKSGTFTLDVAEINIRRWPSLASEVVGSYKQGDTVSFDSEGYANGYYWISYVGGSGMRNYMAIGITDKDGNIISLWGKLV
Physico‐chemical
properties
protein length:214 AA
molecular weight:23219,6 Da
isoelectric point:4,37
hydropathy:-0,13
Representative Protein Details
Accession
7ocj2
Protein name
7ocj2
Sequence length
207 AA
Molecular weight
23057,70090 Da
Isoelectric point
4,56743
Sequence
MATVREVLDFIVYLAKIGSGVDNDQMYGFQCADIPAYISYHYFGKWLWGNAIDLLNSAKAQGFDVIYEGDGVIAKAGDIFVMEVPGSPYGHTGIVIEDSDGYTLKTIEQNIDGNWDFLEVGGPARFNTRSYAGMVGYIRFPYGSDTSTPVQREGWIQDSVGWYFKNQDGTYPFNAWKNIDGNWFDSILMAMLLRILGSRTMKASGIG
Other Proteins in cluster: phalp2_25333
Total (incl. this protein): 56 Avg length: 238,4 Avg pI: 6,65
Protein ID Length (AA) pI
7ocj2 207 4,56743
11B4J 222 9,08271
1ketX 237 6,06639
1mKz3 237 6,41379
2aJRf 244 4,46296
3c56h 244 4,49485
3lAO5 222 9,09696
415W5 269 9,47171
5M2LQ 200 4,44267
62pjU 250 9,44715
69eyo 168 6,54833
6ZRju 239 4,19514
6ev7k 239 6,29153
6ucRO 250 9,35006
6wnef 244 4,57545
75ALx 222 9,09676
769FL 247 8,70415
7AMCA 249 7,58951
7AiDp 237 6,41379
7AozU 238 5,79101
7PCJO 238 6,29005
7Xupw 266 9,56416
7bgK8 227 6,90028
7enNa 222 8,96364
7jKZa 253 6,41709
7prSB 226 7,73257
7us2S 222 9,20056
7vkKP 222 9,09696
7xTcY 229 9,00000
82tzT 238 6,82633
835Xp 294 4,48240
8HLZk 236 5,61174
8HLZm 238 6,96144
8JNqF 250 8,18428
8KX7g 233 9,69258
8L6vs 237 6,41402
8LR01 249 6,41373
8LVEK 250 6,08157
8Leb6 238 6,82678
8MR4c 250 6,88010
8Mz90 249 6,81309
8bDYl 244 4,45086
Db6n 250 9,31073
OAmL 250 9,35006
A0A4D6AFV4 254 4,18872
A0A4D6AGY0 254 4,18872
A0A4D6AXK6 240 9,12681
A0A4D6AZ53 242 4,40647
A0A1S6L127 238 6,96144
A0A4D5ZX92 241 4,42835
A0A4D5ZY44 254 4,13188
A0A4D6A0R1 254 4,23538
A0A4D6AQ21 254 4,13188
A0A4D6B4A2 214 4,46103
A0A4D6B7S5 214 4,40982
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_13805
70eSG
 253 71,7% 184 4.187E-85
2 phalp2_568
Omza
 65 54,7% 146 1.645E-53
3 phalp2_27772
7kL3N
 52 30,3% 132 4.100E-32
4 phalp2_13870
7vCZb
 24 27,9% 143 1.397E-23
5 phalp2_39580
6iLgH
 177 25,7% 167 1.676E-22
6 phalp2_14804
73AW6
 35 30,1% 159 2.286E-22
7 phalp2_368
7aJP9
 3 28,9% 145 2.734E-21
8 phalp2_11577
18WTO
 29 29,4% 139 1.331E-18
9 phalp2_11601
1gImm
 4 24,4% 180 2.467E-18
10 phalp2_13321
3POc0
 3 20,1% 203 9.963E-17

Domains

Domains [InterPro]
CHAP
Representative sequence (used for alignment): 7ocj2 (207 AA)
Member sequence: A0A4D5ZZQ8 (214 AA)
1 207 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF05257

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptococcus phage Javan129
[NCBI] 		2547994 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK448675 [NCBI]
CDS location
range 41306 -> 41950
strand +
CDS
ATGCAGTGTGCTGACTTACCATGTTTTATCGTCAAAAACTGGTTCGGCATTGATTTATGGGGTAATGCCATAGACCTGTTAAATAGCGCATCTGCGCAAGGGCTAGAGGTCATATATAATGCCCCTGGAGTCAATCCCAAAGCTAGTGACCTTTTTGTCATGGAGGTAGCTGGTAGTCCCTACGGACATACAGGAGCTGTTATTGAGGACAGTGATGGCTATACCATTAAAACTGTTGAGCAAAACATTGACGGCAACTGGGACAGTTTACAAGTAGGTGGCCCCGCTCGTTTTAACACTCGTGATTTTACTGGCGTTGTCGGCTGGATTAGGTTACCTGTTGACCATACTAACCAGACGGTGGATACAGCACCACAAACCTCTGACACCATCGTGGAGACATCAAAATCTGGTACCTTTACGCTTGATGTCGCAGAGATTAATATTAGACGTTGGCCAAGCCTTGCGAGCGAAGTAGTAGGTAGCTATAAGCAAGGTGATACTGTCAGCTTTGATAGCGAGGGTTACGCCAATGGTTACTACTGGATTAGCTACGTTGGCGGCTCGGGTATGCGAAACTACATGGCTATTGGGATAACTGACAAAGACGGTAACATTATCAGCCTTTGGGGTAAATTAGTGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0003824 catalytic activity molecular function None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7ocj2) rather than this protein.
PDB ID
7ocj2
Method AlphaFoldv2
Resolution 75.58
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50