Protein

Protein accession
A0A451ED88 [UniProt]
Representative
3R3GB
Source
UniProt (cluster: phalp2_32931)
Protein name
Peptidase M23 domain-containing protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MGGPIFAWPVRPKANSYVAAGYLDPAYARSMGVPHTGEDWNLRTGGDSDLGYPVQAVFPGTVVAAGWYRVWGNLVVVRVDPWVQELLQKALGEPLEDLYVRYGHLHHTVVTQGQQVDAGECIGSIGKGDGGRYMAHLHIDFPRMRIPPDAYPRTEAQVRAQYLDPARVWGALSFADRPNLLPSGRLYAPVRYIGKDLEAPRGAWVRRVEERLWVRPVSEEA
Physico‐chemical
properties
protein length:221 AA
molecular weight:24628,7 Da
isoelectric point:7,02
hydropathy:-0,30
Representative Protein Details
Accession
3R3GB
Protein name
3R3GB
Sequence length
194 AA
Molecular weight
21305,10110 Da
Isoelectric point
7,29320
Sequence
LPVALDIDEIMGAYPIRPWQSCKVDAGFLDAGYYRAFRRWHKGVDINLKSGGDSDLGYPVQNMFAGKVVFAERVVGSWGGIVLVRAGSVSVQHAADMTGIVMDVLDVQYAHLHHVTVKTSDIVRAGDHVGSIGKGTRNQYTAHLHLEMRRTIRPAAEGQGGDDEAKRIAKVHYLDPLAMMTAIKLSNYGREEMS
Other Proteins in cluster: phalp2_32931
Total (incl. this protein): 42 Avg length: 207,9 Avg pI: 8,01
Protein ID Length (AA) pI
3R3GB 194 7,29320
1HnlZ 214 8,76359
1X3KZ 220 8,62666
2WGRk 210 8,10866
2vg42 210 6,75886
2w7Mp 203 8,03587
33RC 195 6,53395
3NPH2 216 9,47223
3NsQP 194 8,07249
3OU7T 216 9,06575
3UcL5 216 8,71434
3f7ns 210 7,15349
3fp5h 212 9,02262
41tX7 216 8,73813
4T5Aj 182 6,86793
4X6Ib 213 8,71053
4lNUp 210 8,12922
4ujf6 174 8,12452
4wd1D 180 8,10975
5Dm1y 215 8,50385
5Dm4D 202 7,20988
5DmB7 214 8,83244
5Dmrd 213 8,73793
5FolC 194 6,71373
5niv4 212 8,67114
6IhOZ 210 8,14044
7KkUr 218 8,02672
7cXdf 230 7,25450
7cXe5 210 8,06785
7e4wh 210 7,18197
7oh71 210 7,15105
7rxRP 210 8,12922
8cd9m 213 8,73761
8ewm9 211 7,95432
8exCh 213 8,73671
8ngVQ 214 6,83372
9ua2 212 8,75508
bZ7y 211 7,17333
f0sO 177 7,88811
kgMa 215 9,33968
kgvm 210 7,15349
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_6932
2NqNa
 4 42,7% 131 5.256E-48
2 phalp2_7808
7wmb4
 4 31,3% 182 1.222E-31
3 phalp2_15995
7QoNY
 18 28,8% 156 6.203E-26
4 phalp2_15506
8dpQy
 1 26,2% 164 4.880E-19
5 phalp2_25763
4QogS
 4 25,9% 154 2.300E-18
6 phalp2_21326
1KVjU
 4 29,2% 147 1.082E-17
7 phalp2_36356
pX1x
 19 22,8% 162 1.536E-13
8 phalp2_16005
3mTXp
 16 31,3% 137 3.857E-13
9 phalp2_24251
361WA
 36 24,1% 186 2.425E-12
10 phalp2_2134
3nSFE
 102 23,2% 146 5.146E-11

Domains

Domains [InterPro]
PET_M23
Representative sequence (used for alignment): 3R3GB (194 AA)
Member sequence: A0A451ED88 (221 AA)
1 194 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Thermus phage phiMa
[NCBI] 		2301537 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH673674 [NCBI]
CDS location
range 16880 -> 17545
strand -
CDS
ATGGGAGGGCCCATCTTTGCCTGGCCCGTTCGGCCCAAAGCGAACTCCTATGTAGCCGCGGGCTACCTCGACCCGGCCTACGCGCGAAGCATGGGTGTCCCCCACACCGGGGAGGACTGGAACCTCCGCACGGGCGGGGACTCCGACCTGGGCTACCCCGTTCAAGCCGTTTTCCCGGGGACGGTGGTAGCCGCGGGGTGGTACCGGGTGTGGGGGAACCTGGTGGTGGTCCGGGTGGACCCGTGGGTTCAAGAGCTCCTCCAGAAGGCCCTGGGGGAGCCCCTCGAGGACCTCTACGTCCGCTACGGCCACCTCCACCACACGGTGGTCACCCAGGGCCAACAGGTAGACGCCGGAGAGTGCATAGGGAGTATCGGGAAGGGGGATGGGGGGCGCTATATGGCTCACCTCCACATAGACTTCCCCCGGATGCGCATCCCCCCGGATGCATACCCGAGAACAGAAGCCCAGGTGCGGGCCCAGTACCTGGACCCGGCCCGGGTCTGGGGGGCCCTGAGCTTCGCAGATCGCCCCAACCTCCTCCCTTCGGGGCGCCTCTACGCCCCCGTGCGCTATATCGGGAAGGACCTCGAGGCCCCCCGCGGGGCCTGGGTGCGGCGGGTGGAGGAGCGGCTCTGGGTCCGGCCCGTGTCAGAAGAAGCATGA

Gene Ontology

Description Category Evidence (source)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3R3GB) rather than this protein.
PDB ID
3R3GB
Method AlphaFoldv2
Resolution 91.76
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50