Protein

Protein accession
A0A3S9UCX9 [UniProt]
Representative
8IzI7
Source
UniProt (cluster: phalp2_29259)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTYQLFEGHTSRNFTPGAQANAVWGQGPRRVESITIHWWGNYGQEFWTVEGFLCTNTKPTSAHFVAQEGLVSCIVSPDDAAWHAGNPYGNTTSIGIECRPEATDGDYQTIAELVAYLRSIYGDVPLVHHYEWQSTACPGTYDLARIDRLSRGVNVPTINEGDLTVAEVDRAIAYVKALASDGWTDAQGKKHPGFMFVIEENQRLIQALPAAVAKAVWDTNINRGTAEKPVYVRALQDLANNGTDTARVMADVKTLIDRPAGSGGAVDTEAVAQSVFDKIIAWLKR
Physico‐chemical
properties
protein length:285 AA
molecular weight:31213,5 Da
isoelectric point:5,25
hydropathy:-0,25
Representative Protein Details
Accession
8IzI7
Protein name
8IzI7
Sequence length
461 AA
Molecular weight
49873,56990 Da
Isoelectric point
4,95996
Sequence
MPISQTQETWLLNAVGKIFDYDRSYGYQCVDLADAYGQDIFGVPWQTSVGGVGGARELLDRVPDEYWIRIDNDPNDPNLIPERGDMVVFAGSPLNPFGHVAIVLSADGSGMWVVQQDGFAPPLQFVNGNWYSAKPAHKAWLPYTGDGTGVIAGWLRPRQNKIIGGGASVLPAGDVTGGIVTDFVIDESYTAKGFTPAAQVPAVYGGPRTIESITIHHWGALGQTHMGVVNFFCVTGPGTTSAHFVSSAGKTHCIVSPLDAAWHAGNGTGNRTSIGIECRPEATDGDYLEVAKLIAWLRSKYGDLPLIPHRDWQATACPGVWDLARLDKLARSQEVQQEDDMFTDDDRRMLKAIKDGWFIGGSDTLYKAPWQKLIDDIPRRVWDTKVTGRKEGAVSALQELADSKTNTIAILAKLDGLTEAVRQLATGQGLDPELITSTIDNAVKNALGEIRLTTVAAEVGE
Other Proteins in cluster: phalp2_29259
Total (incl. this protein): 88 Avg length: 347,8 Avg pI: 5,47
Protein ID Length (AA) pI
8IzI7 461 4,95996
3V3Rv 465 4,93433
7zTyY 467 4,92518
8Leh1 464 4,97270
A0A0U4B6P5 461 4,95996
A0A514A6P8 285 5,16885
A0A1I9SE50 278 5,26672
A0A3G8FUI7 287 5,25263
A0A0M4RB81 536 5,53654
A0A5B8WEP2 529 5,71177
A0A222Z9J2 530 5,64050
A0A222ZIX0 529 5,70671
A0A221J6T7 213 5,50914
A0A0U4JT40 285 5,25860
A0A0U4JTJ1 287 5,31407
A0A0U4KMZ8 285 5,26809
A0A0U4B7G6 279 5,22813
A0A0U4K087 535 5,52239
A0A0U4K8K2 285 5,26809
A0A286S1R3 467 4,92518
A0A222Z7U7 532 5,53984
A0A482JEZ0 213 5,34277
A0A5Q2WCY6 214 5,51574
A0A3S9UMA7 285 5,26809
A0A222ZGE5 278 5,09854
A0A1C9LZI4 287 5,15958
A0A222ZH17 278 5,25860
A0A0U4K1Z4 285 5,26809
A0A0U4B7M6 278 5,10757
A0A222ZG88 287 5,26149
A0A3S9U9Z5 285 5,26809
A0A0U4JPJ5 464 4,97270
A0A0U4B1M4 285 5,15009
A0A140G755 529 6,11186
A0A1C9LZB1 278 5,17811
A0A345KLP6 280 5,33112
A0A0U4IHI0 461 4,90676
A0A0U4JEI5 532 5,44508
A0A0U4JHM3 278 5,26672
A0A0U4JMT1 532 5,44508
A0A0U4KMN9 287 5,26149
A0A0U4KRD4 532 5,44003
A0A1I9SDY8 278 5,26672
A0A222Z0I2 529 6,11186
A0A222Z9B2 529 5,71177
A0A222ZGF7 287 5,26149
A0A222ZH75 213 5,34277
A0A2H4P9K1 285 5,26809
A0A386K9K8 285 5,25263
A0A386KNJ3 529 6,11186
A0A3G8FTU8 285 5,26809
A0A3G8FU56 287 5,26149
A0A3G8FUS1 285 5,26809
A0A3G8FV53 279 5,22813
A0A3S9U9K3 287 5,26149
A0A3S9UAA8 287 5,26149
A0A3S9UBM8 279 5,22813
A0A3S9UDY4 287 5,26149
A0A3S9UEJ0 287 5,15958
A0A3S9UFR6 287 5,26149
A0A3S9UFS0 279 5,22813
A0A3S9UFX6 287 5,25263
A0A3S9UGQ4 287 5,25263
A0A3S9UH45 279 5,22813
A0A3S9UHB4 285 5,26809
A0A3S9UHQ2 285 5,26809
A0A3S9UJ71 279 5,22813
A0A3S9UJM9 285 5,26809
A0A3S9ULS9 285 5,26809
A0A3S9UQ30 285 5,25263
A0A482J991 213 5,34277
A0A4D6E3N8 285 5,26809
A0A4D6T623 285 5,27656
A0A514A5H1 532 5,44508
A0A5B8WKI3 532 5,53984
A0A6B9LDZ0 287 5,26149
A0A6B9LUT5 278 5,10757
A0A6M3T7D2 529 6,11186
A0A7G8LQS4 529 5,51471
A0A7M1CSA8 532 5,54438
A0A7T1KS39 285 5,25860
A0A9X9K315 278 5,26672
A0AA96K5F0 287 5,25263
A0A8A5LUD3 236 9,72140
A0A9E7QGG9 529 5,75810
A0AA49BRM5 236 9,55965
A0AAE8XJY9 235 9,65010
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_30290
4nPdY
 1 34,3% 349 2.928E-60
2 phalp2_18952
3MmP0
 1 25,9% 351 8.764E-12
3 phalp2_2230
4k5IM
 1 22,1% 357 1.195E-07

Domains

Domains [InterPro]
CHAP
Ami2
Unannotated
Unannotated
Representative sequence (used for alignment): 8IzI7 (461 AA)
Member sequence: A0A3S9UCX9 (285 AA)
1 461 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF05257

Taxonomy

  Name Taxonomy ID Lineage
Phage Arthrobacter phage Huckleberry
[NCBI] 		2499005 Korravirus > Korravirus bennie
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK279856 [NCBI]
CDS location
range 18441 -> 19298
strand +
CDS
GTGACTTATCAGCTGTTTGAGGGGCATACGTCCCGCAACTTCACTCCGGGCGCTCAGGCCAACGCGGTCTGGGGCCAGGGTCCTCGCCGGGTCGAATCGATTACGATTCACTGGTGGGGCAACTACGGCCAGGAATTCTGGACCGTCGAAGGCTTCCTGTGCACGAACACCAAGCCGACCTCGGCGCACTTCGTGGCACAGGAGGGCCTCGTGTCCTGCATCGTCTCACCGGACGACGCAGCATGGCACGCGGGCAACCCGTACGGCAACACCACTTCCATCGGCATCGAGTGCCGACCGGAGGCCACGGACGGGGACTACCAGACCATCGCGGAGCTGGTGGCGTACCTGCGTTCCATCTACGGCGACGTACCGCTCGTGCACCACTACGAGTGGCAGTCCACGGCATGCCCTGGGACTTACGACCTCGCCCGCATCGACCGCCTCTCCCGAGGCGTCAACGTACCAACAATCAACGAAGGAGATTTGACCGTGGCAGAAGTAGATCGCGCTATCGCGTACGTAAAGGCTCTGGCCTCTGACGGCTGGACCGACGCTCAGGGCAAGAAGCACCCGGGCTTCATGTTCGTGATCGAGGAGAACCAGCGCCTGATCCAGGCCCTCCCGGCAGCAGTGGCCAAGGCAGTCTGGGACACCAACATCAACCGAGGCACCGCTGAGAAGCCGGTCTACGTCCGGGCACTGCAGGACCTCGCCAACAACGGCACCGACACTGCCCGTGTCATGGCCGATGTAAAGACGCTGATCGACCGGCCTGCCGGATCGGGTGGCGCAGTGGACACGGAGGCAGTAGCCCAGTCCGTGTTCGACAAGATCATCGCTTGGCTCAAGCGCTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0009254 peptidoglycan turnover biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8IzI7) rather than this protein.
PDB ID
8IzI7
Method AlphaFoldv2
Resolution 75.28
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50