Protein

Protein accession
A0A3G8FD45 [UniProt]
Representative
6iQWP
Source
UniProt (cluster: phalp2_12156)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKIKRTFAIFALVAALLLQSTAYAAAGDHGVDWSRYQGANGIFGYPHDKFAIAQIGGVNGGGIYGQTTYETQVASAIAQGKRAHTYIWYQVGGNASLGEQVLNTFLPQVQTPKGSIVALDYESGASADKQANTNAILHGMRMIKAAGYTPMYYSYKPYTVANVYVDQIIREFPNSLWMAAYPDYNVTPKPNYNVFPSMDGVAIYQFTSTYIAGGLDGNIDLTGITDNGYTKNNNPKTETPAIVEGKQADNTPKSDIAVGNQVKVKFGAVSWATGEAIPSWVKGRTYSVAKVSGKRVLLSGINSWINKSDVEIISVANTQATQVTATSTYTVQPDDTLSGIASKFGTSYQTLASLNGISNPNWIYVGQVLKVTGSANAGSVYYTVRADDNLSAIASRYGTSYQSIASLNGLANPNLIYAGQTLKIK
Physico‐chemical
properties
protein length:425 AA
molecular weight:45543,6 Da
isoelectric point:9,03
hydropathy:-0,15
Representative Protein Details
Accession
6iQWP
Protein name
6iQWP
Sequence length
259 AA
Molecular weight
28095,47600 Da
Isoelectric point
6,95410
Sequence
MLMKIKRLLLGALLGASILLQSTAYAAVGDQGVDWSRYQGANGIFGYGHDKFAICQIGGVNGGGIYGQSTYETQVASAIAQGKRAHTYIWYQVGGNASLGEQVLNTFLPQVQTPKGSIVALDYESGASADKQANTNAILHGMRMIKAAGYTPMYYSGKPYTVANVYVDQIIREFPNSLWMAAYPDYNVTPTPNYNVFPSMDGVAIYQFTSTYIAGGLDGNIDLTGITDNGYTKNNNPENQHQLLAKVNKQIIHLNLTLL
Other Proteins in cluster: phalp2_12156
Total (incl. this protein): 264 Avg length: 332,4 Avg pI: 8,37
Protein ID Length (AA) pI
6iQWP 259 6,95410
1Di 373 9,58208
1FDtQ 244 9,03926
1FWwM 315 6,44642
1QQ48 207 8,60094
1Z0P8 205 8,79995
1Z1oD 398 9,32498
1Z1sJ 411 9,48725
1Z20H 171 9,02578
1c027 247 6,11652
1deeB 304 5,56320
1gRCA 304 6,21173
1nFZy 318 6,52281
1oo9y 314 8,33803
1oobH 315 5,63424
28vJB 376 9,30912
28vT9 312 9,32092
28vuq 411 9,47906
290sT 293 9,64713
2X57X 309 7,01475
2dhrH 315 8,09718
2jDjs 169 9,41640
2kVPM 236 8,41901
2l4Ly 379 9,34645
2l4wA 328 9,57293
3KR41 192 9,33001
3jHFd 310 8,36543
3kFsX 315 9,39486
3quZE 388 9,70721
3wW0j 297 9,92750
3wryO 407 9,62224
3xDfH 193 9,19430
3xEXs 413 9,63959
3xEYV 189 9,00161
3xPtw 293 9,75331
3yz3X 374 9,53747
4SBFL 293 9,63224
4SCbM 297 9,67988
4SE5j 296 9,82513
4SFF2 296 9,79863
4Sv60 296 9,78645
4VVo1 270 4,91694
4xFFT 303 5,22438
5ET6d 278 8,40714
5HDOY 303 5,22438
5HGBK 314 8,29278
5HGdm 314 5,72320
5Krfa 313 6,16154
5NEZR 315 6,43818
5NVL8 311 7,58706
5Ndwk 298 9,66183
5NqKO 303 5,32987
5O2VC 315 8,60229
5OIA5 312 7,66789
5RtQK 265 8,86474
5S0vA 292 9,70315
5VuNy 373 9,48190
5Wahr 312 5,44184
5WgtZ 296 9,68826
5XddA 316 6,33967
5oFIU 316 9,05537
5oGIe 302 9,67562
5oGb4 315 8,93379
5oJCO 300 9,50601
5tD6g 282 8,58308
5tDWB 314 6,82985
5tTlK 298 9,55539
5u0A7 290 9,84118
63UFF 411 9,25948
69pxJ 314 8,28717
6YKlT 373 9,61941
6YqB7 373 9,59452
6ZRdK 314 5,71081
6ZTjN 298 9,62495
6ZcTD 294 9,93234
6cFPn 303 5,31242
6gGry 300 9,59975
6kP0E 178 7,84711
6lDPA 315 6,89522
6mHVp 240 6,81746
6ojuh 373 9,59175
6qCRc 235 8,80002
6qgkA 399 9,34155
6r6YJ 383 5,30265
6tUAo 298 9,61238
707Qt 300 9,61586
70Q47 294 9,55462
70cyF 285 9,41195
71uqr 323 8,71595
72SYh 373 9,59175
72dYI 315 9,50498
72dZL 317 8,84205
72dbn 250 9,38990
72dd4 252 9,38990
73uA3 311 8,20291
74AmP 170 9,07974
74AnC 170 9,07974
756oN 314 7,57819
76qmN 315 7,56615
78TB9 308 9,34342
790E5 208 4,82400
790G8 220 5,89769
7AUJG 310 8,88440
7BOvH 376 9,70238
7BgVF 298 9,63005
7C1IB 292 9,70335
7C1KT 361 9,23679
7C1KU 296 9,66228
7C4cJ 376 9,63681
7Mpq1 307 9,56803
7Ooc0 311 8,51365
7POWN 398 9,60574
7QDFa 296 9,54108
7QDiI 373 9,63598
7QE3V 311 5,57564
7Ro5v 315 6,52343
7Ro6E 311 8,16764
7Rodu 298 8,69390
7WF6l 225 5,52489
7WKnH 195 9,34967
7XkUw 207 9,40415
7XlKf 252 8,59649
7boUE 373 9,60168
7boVp 373 9,63694
7cnEG 297 9,54301
7d7l6 303 9,39519
7dX3F 225 9,15382
7dX3K 372 9,57480
7eSf7 296 9,64584
7eZNc 206 9,00109
7eZO3 206 8,98710
7esb9 373 9,43522
7euw0 424 9,10643
7f7Ve 310 5,82852
7fn0Z 299 10,09016
7gy4k 293 9,06827
7iNb1 290 9,79199
7jPAd 297 5,44247
7lFlV 209 8,81317
7lghk 283 9,46346
7lzvn 314 8,32482
7lzwr 312 8,78783
7py6B 373 9,59452
7qSYV 300 9,38365
7rkcM 373 9,58808
7tfO2 318 7,70887
7toyz 311 6,17728
7u3Wr 317 7,59110
7u42d 390 9,62315
7u44J 390 9,79508
7v8kL 254 7,71222
7vQmB 300 9,71108
7vyGk 215 9,35096
7vyGl 215 9,58692
7wLwu 361 9,35038
7wLxv 297 9,71463
7x3PA 317 8,84173
7xJtp 317 8,45285
7xRor 369 9,40492
7xeAK 252 5,20630
7xnvJ 343 9,35199
7y6g0 315 6,83235
7y6oU 303 5,30941
7z6uo 392 9,66982
7z8hA 304 6,20889
7zrsJ 303 5,30941
7zrt2 303 5,13003
81LTk 373 9,65551
85a8N 303 5,04778
86j5O 298 8,71556
88HtI 313 8,53653
8K2ri 398 9,42929
8K2sv 398 9,44625
8K2tm 391 9,71727
8K2vT 317 8,32559
8K2vU 315 7,69807
8K2vV 313 9,01727
8M7cc 294 9,68162
8MMcb 413 9,60961
8MSto 413 9,57866
8hdWx 305 7,55665
8ieuA 310 8,68584
8lTOW 303 9,70902
8lp2M 309 8,74438
CYi7 320 7,55893
CYjz 302 8,81226
CYlw 373 9,61618
D0fe 373 9,61618
D0k2 318 7,68710
D3mn 373 9,56596
D8T5 297 9,66280
DaYE 309 9,47126
Daab 373 9,64913
Hkji 373 9,67956
Onmv 373 9,66383
b16V 286 9,59897
b1ba 291 9,54907
lZGN 251 4,76319
njCQ 280 4,88636
qGU6 371 9,68239
qaQO 313 8,83960
ufVv 298 9,58556
wu6X 214 9,16310
wuzg 373 9,61586
A0A097QQ33 142 8,75379
A0A7H0XC51 433 4,96815
Q9AZ52 429 6,22946
Q8LTP4 429 6,53526
A0A4D6A3Q6 427 8,28317
A0A0S2MYF3 419 5,11332
Q597T9 398 9,60574
Q37969 429 9,00921
A0A649V1A8 429 7,71046
D2J077 433 4,96815
A0A4D6AM64 434 6,52872
A0A4D6BCX7 434 6,96547
A0A4D6AV62 424 9,11610
A0A4D6A326 423 9,04306
A0A4D6A4B7 424 9,10643
A0A4D6BHJ1 433 6,23191
A0A1B1IM89 429 7,69392
A0A059NT93 429 6,08975
A5GYL4 429 7,71449
A0A1P8BMS7 448 8,30632
A0A1P8BKY1 429 8,32205
A0A1P8BLG2 429 7,70171
D2IZV5 419 4,85089
A0A2P0ZL86 398 9,42929
A0A1X9IGI4 355 5,38711
A0A2K9VBX9 398 9,44625
A0A2P0ZLH5 342 9,71431
Q38614 428 8,77249
D2IZI1 433 4,95729
G8FV30 413 9,60961
A0A1B1IMU2 429 8,60113
A0A1P8BKP8 429 7,70597
A0A1P8BL59 429 7,70171
A0A1P8BL87 429 8,31412
A0A3S7UNK7 258 7,71108
A0A4D6A6Y1 425 8,36962
A0A4D6A965 425 8,36962
A0A4D6AUG5 427 8,36053
A0A4D6AYW5 427 7,65243
A0A4D6BDY3 434 6,96394
A0A649V111 429 7,71046
A0A649V1Y1 429 7,70171
C9E2L1 419 5,08308
E9LUR8 390 9,65944
Q9FZS8 429 8,60049
Q9T1Z3 429 9,22138
R9QM37 429 7,70597
A0A649V1J8 429 9,10585
A0A8E5NQ96 355 9,54598
A0A8S5PE27 425 8,73445
A0A8S5R3X9 425 8,78448
A0A8S5SKK6 329 9,52084
A0A8S5V5N2 426 8,92270
A0A977KEI5 429 8,61757
A0A977KEV6 429 7,72120
A0A977KFQ5 429 6,53207
A0AAE8BHR8 419 4,92728
A0AAE9VHP6 422 9,29081
A0AAE9W0M2 389 8,58488
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_11124
5oePU
 31 33,6% 220 3.008E-81
2 phalp2_387
7iNag
 20 37,0% 243 4.235E-66
3 phalp2_1050
734XP
 69 33,6% 235 1.788E-55
4 phalp2_33827
1mUYf
 73 39,3% 234 4.102E-54
5 phalp2_36893
7v6GH
 34 56,1% 162 1.758E-52
6 phalp2_22092
5WvnN
 1 27,4% 204 2.396E-29
7 phalp2_362
76MmF
 5 28,9% 221 8.246E-29
8 phalp2_8064
5PT62
 85 19,3% 227 3.208E-19
9 phalp2_14039
89f4d
 3 21,5% 176 4.926E-18
10 phalp2_36157
6TiaL
 25 24,7% 210 1.222E-17

Domains

Domains [InterPro]
Disordered region
GH25
Representative sequence (used for alignment): 6iQWP (259 AA)
Member sequence: A0A3G8FD45 (425 AA)
1 259 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptococcus phage CHPC1109
[NCBI] 		2365027 Aliceevansviridae > Brussowvirus > Brussowvirus CHPC1109
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH937505 [NCBI]
CDS location
range 20629 -> 21906
strand +
CDS
ATGAAGATTAAACGAACTTTTGCCATCTTTGCGTTAGTGGCAGCCTTATTGTTACAGTCCACGGCTTATGCTGCAGCAGGCGACCATGGAGTTGACTGGTCACGTTATCAAGGTGCTAATGGTATCTTCGGTTATCCTCATGATAAGTTTGCCATCGCGCAAATTGGCGGGGTTAACGGTGGCGGTATTTACGGACAAACAACATATGAAACACAAGTAGCTTCGGCAATCGCTCAAGGCAAGCGTGCACATACTTATATTTGGTATCAGGTCGGCGGAAATGCTAGCCTTGGTGAGCAAGTCTTAAATACATTCTTGCCACAGGTTCAAACGCCAAAAGGCTCAATCGTAGCCTTGGACTACGAAAGTGGTGCTAGCGCTGACAAGCAAGCAAATACTAACGCAATCTTGCATGGTATGCGTATGATTAAAGCTGCAGGTTATACACCTATGTACTATAGTTACAAGCCTTATACAGTCGCTAACGTGTATGTTGACCAAATCATTCGCGAGTTCCCGAACTCGCTTTGGATGGCTGCTTACCCAGATTACAACGTGACACCAAAACCAAACTACAATGTCTTCCCGTCAATGGATGGCGTGGCAATATACCAATTCACATCAACATATATCGCTGGCGGTCTTGACGGTAATATTGATTTAACTGGTATTACGGACAATGGCTATACCAAGAACAATAATCCAAAAACCGAAACTCCAGCTATTGTTGAAGGTAAACAAGCGGACAACACGCCAAAATCTGACATTGCTGTAGGAAATCAAGTTAAAGTCAAATTTGGTGCTGTAAGCTGGGCGACTGGTGAAGCTATTCCAAGTTGGGTTAAGGGTCGCACATACAGCGTAGCTAAAGTTTCTGGCAAGCGTGTACTATTGTCTGGTATTAACTCATGGATTAACAAATCAGATGTTGAAATTATTTCAGTAGCTAATACACAAGCAACGCAAGTGACTGCAACTAGCACTTATACAGTCCAACCTGACGATACATTATCTGGAATCGCTTCAAAATTTGGAACAAGTTACCAAACACTAGCAAGCCTTAACGGTATTTCAAATCCTAACTGGATTTATGTTGGGCAGGTCTTGAAAGTGACTGGTTCAGCAAACGCTGGCTCTGTCTACTACACAGTTAGAGCAGACGATAACTTGTCAGCAATTGCAAGCCGCTATGGCACAAGCTACCAATCAATTGCAAGCCTCAATGGTCTTGCTAATCCAAACTTGATTTATGCAGGACAAACGCTTAAAATTAAATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6iQWP) rather than this protein.
PDB ID
6iQWP
Method AlphaFoldv2
Resolution 86.45
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50