Protein

Protein accession
A0A3B8DKS2 [UniProt]
Representative
4EicH
Source
UniProt (cluster: phalp2_37804)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAMALSDLFGALARLFGVNPAPVVDVPTSAIESAKMDIAGSAVPLPAAPDTGLAVGGAEIAPAVPQNVPSGTDDGAWLALCRPLSQHFESCYLTAYPDPASDLGKALQARGLWYKVLGGAPIPNDPALRALSGAPWTCGWGSTGPDVREGTVWTQATADARHDANLRASAALVDQAARVPLSPQQKAALVSIVNNVGPGRARRVNDPGRDGIITLASGQPSTLLRHLNIGDMAGAADQFPAWNRAGGVVLPGLVRRRAAERDLFLTGAWSDA
Physico‐chemical
properties
protein length:272 AA
molecular weight:28060,5 Da
isoelectric point:5,90
hydropathy:0,02
Representative Protein Details
Accession
4EicH
Protein name
4EicH
Sequence length
216 AA
Molecular weight
23706,06260 Da
Isoelectric point
4,12250
Sequence
MTFIPHSAHPGIPSARGGWFVKPHNPHQKPPADIDEDDWLVQCEPLTQCFEGCYLTAYPDPCSPMANALVGAGIWYDVLAGAPIPAQYASLDPDPWSCGWGQTGDDVSEGTEWTQDYADMRLGYTLEDCGDDVDRLVIVPLTAYQKAALADFIYNEGVGNFESSTLLALLNQADYAGAADEFPKWNLAGGEVNSWLVKRRACEQELFLTGTWTQPD
Other Proteins in cluster: phalp2_37804
Total (incl. this protein): 34 Avg length: 257,2 Avg pI: 6,75
Protein ID Length (AA) pI
4EicH 216 4,12250
5CkWy 270 5,91673
5yYqQ 214 5,65994
6COPU 273 8,67817
6E7aq 273 8,91167
6JebQ 273 8,91167
6KPox 187 4,41999
6RvOh 200 8,59752
6XPdT 249 5,29452
78X6T 254 8,36369
7cNsL 274 6,51121
7dcM7 270 6,06787
7e8fP 270 6,06787
7eAzM 270 6,41288
7hZ9F 270 5,60867
7itbE 270 6,06787
7nP0g 260 6,89829
7nPex 253 6,90090
7nQcz 260 5,77907
7nRMT 276 7,67812
7qLxE 272 8,79602
7qMWO 272 9,09386
7qWOb 306 7,68113
7qspA 290 7,77048
7r5Gd 270 5,37409
7tfrU 274 6,07787
7tfud 274 8,55207
7tm7l 208 8,99129
7xosN 270 5,77663
86lGo 191 5,30719
hqez 220 5,62094
A0A3B8DKK9 272 5,90059
A0A5S9CB92 272 5,90059
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_29165
7sDhB
 3 51,1% 176 2.414E-72
2 phalp2_9226
6S6V5
 37 45,7% 175 1.937E-51
3 phalp2_3516
4qTfc
 7 40,9% 166 2.395E-47
4 phalp2_33221
5jbqV
 447 44,8% 165 1.275E-44
5 phalp2_2176
3Yhf4
 930 36,7% 204 1.275E-44
6 phalp2_8252
7B99h
 46 35,9% 164 8.294E-41
7 phalp2_2632
6RhYr
 14867 41,1% 163 2.333E-38
8 phalp2_28113
7zmZV
 50 40,1% 167 3.190E-38
9 phalp2_3619
4ONI2
 18 40,2% 179 8.162E-38
10 phalp2_17663
6R9yG
 6 38,0% 168 3.804E-34

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 4EicH (216 AA)
Member sequence: A0A3B8DKS2 (272 AA)
1 216 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Burkholderia phage phiE058
[NCBI] 		2321389 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH809533 [NCBI]
CDS location
range 24630 -> 25448
strand +
CDS
ATGGCGATGGCGCTCAGTGACCTGTTCGGCGCGCTCGCGCGGCTGTTCGGCGTGAACCCGGCGCCGGTCGTCGACGTGCCGACGTCCGCGATCGAGTCGGCGAAAATGGACATCGCGGGTTCCGCCGTACCGCTTCCGGCCGCTCCTGATACGGGTTTGGCGGTGGGTGGTGCGGAAATCGCGCCGGCTGTACCGCAAAACGTTCCATCCGGTACGGATGACGGGGCGTGGCTGGCACTCTGCCGCCCGCTGTCGCAGCACTTCGAGAGCTGCTACCTCACCGCATATCCGGATCCAGCATCGGATCTCGGCAAAGCGCTGCAGGCGCGCGGCCTCTGGTACAAGGTGCTCGGCGGCGCGCCCATCCCGAACGATCCCGCTCTGCGCGCACTGAGCGGCGCACCGTGGACATGCGGGTGGGGCTCGACGGGCCCGGACGTGCGTGAGGGCACGGTCTGGACGCAAGCCACGGCCGACGCGCGGCACGACGCGAACCTCCGCGCCTCGGCGGCGCTCGTCGACCAGGCCGCGCGTGTGCCGCTGTCGCCGCAGCAGAAGGCCGCGCTCGTCAGCATCGTGAACAACGTCGGGCCCGGCCGCGCGCGGCGCGTGAACGATCCTGGTCGGGACGGCATCATCACGCTCGCCAGCGGGCAGCCGTCGACGCTGCTGCGACACCTGAACATCGGCGACATGGCCGGCGCGGCCGATCAGTTTCCCGCGTGGAACCGCGCGGGCGGTGTCGTGCTGCCGGGTCTCGTGCGCCGGCGCGCAGCCGAGCGCGATCTCTTCCTCACCGGTGCATGGAGCGACGCATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4EicH) rather than this protein.
PDB ID
4EicH
Method AlphaFoldv2
Resolution 86.29
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50