Protein

Protein accession
A0A345MDV6 [UniProt]
Representative
4FizF
Source
UniProt (cluster: phalp2_7405)
Protein name
LysM-like endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MATPMTATQIVAQLKKWGVPYKEYKDWKNHNRNHMGAWGPVNGFMVHHTGSDSKDQRELLYAGISGLPGPLCHFGLAQDGTVHLVGWGRANHAGSGDPDVLKAVIDESYGANPPVDNQSSVDGNARFYGVEIWYSGSHAMSAAQYATLRKLASAICDFHGWSEKSVIGHGEWGSPGKWDPGISSGKMMDMAKVRADVKSTLGGSKTPDPVPSKPADSASTHTVVKGETLWAIANKYKVSVDNLKKWNSLKSDELSVGQKLKVKAPASSGGGTSTVAKKDATYKSVWDLDASTPPKGHETTANPTWAPMSILRGIYENLETLSKKVDELSKKIDALESK
Physico‐chemical
properties
protein length:338 AA
molecular weight:36402,6 Da
isoelectric point:8,90
hydropathy:-0,52
Representative Protein Details
Accession
4FizF
Protein name
4FizF
Sequence length
237 AA
Molecular weight
25469,36160 Da
Isoelectric point
7,26939
Sequence
MSAPLSADAFIRALKAEGLSVHEHANWRSHTRSGSGRPWGPVHGVMMHHTASGTSGIVEYCYRGSSALPGPLCHGVIDKTGLVTLVGYGRTNHAGGGDRDVLNAVIAESYATNPPATHEHQGSDGAVDGNKSFYGFEAVNHGDGKDPWPVVQYEAMVKAAAAICRVHAWTGKSAIGHKEWSDQKSDPKAPWTMATFRHDVAACLAKKPGAWHIVPEPEVKLTVEQRLDRIEKKLGLD
Other Proteins in cluster: phalp2_7405
Total (incl. this protein): 295 Avg length: 284,0 Avg pI: 7,74
Protein ID Length (AA) pI
4FizF 237 7,26939
11A1w 235 8,13902
11xyb 234 7,70318
11zAf 191 8,69757
16luG 312 5,30691
1GVTT 237 8,41669
1GVVG 301 7,82674
1GXcv 258 8,94075
1ICjO 317 5,62896
1NSPm 324 6,30131
1P0VP 266 6,45159
1dw2m 233 6,85412
1jprv 253 8,97505
1p3bY 247 9,35715
1p7FK 296 7,71586
1rcUM 148 6,62932
241U0 257 6,24373
2D9uz 345 5,79965
2Dilr 309 5,06682
2SC8J 268 7,72637
2Tgfe 310 7,82719
2UdoM 235 7,78045
2YGVz 312 8,65947
2YH0w 403 9,33884
2YH9I 277 6,79728
2YH9O 284 8,83006
2Yf9 250 9,73165
2YpxV 292 6,89800
2kNUW 278 6,07543
2oOYJ 260 8,33120
35LbV 299 6,30068
3LBJY 300 8,88750
3N41C 246 8,21799
3NHHp 331 5,82591
3NtIu 236 7,69670
3OQKd 269 6,29886
3OQRA 258 8,00312
3Ptwl 271 7,17276
3SkDV 259 9,46726
3SqZy 224 9,11108
3X8nx 270 6,14113
3dKJq 314 9,66421
3e67S 310 6,04775
3eaP3 290 5,94254
3ebXS 270 7,79528
3edVt 218 8,80666
3ezl0 301 5,19101
3iEIy 278 6,45068
3iFbP 280 9,27115
3qy6 236 6,85401
40xlq 233 5,73377
451SQ 293 9,31209
45GTK 276 5,32197
4F84f 305 5,74082
4FaaQ 233 7,89153
4FiTt 337 9,06575
4FmyX 271 9,36643
4HSo2 306 4,88255
4JjGM 304 5,72900
4JjjZ 245 9,39087
4JkMB 272 5,49374
4JlcE 296 6,19098
4KDSR 247 9,46391
4KG3i 262 9,20314
4Kx0l 292 5,06318
4LAJO 291 5,22489
4LjQQ 244 8,28433
4Lmdt 284 4,90881
4Lw01 260 7,73518
4MDgC 244 8,26428
4MEGR 247 9,44257
4MHr4 290 5,23376
4MXq1 304 5,03243
4MYil 311 6,15313
4MkTl 329 5,47214
4Ml5g 327 6,31256
4N4bs 293 6,24782
4OjBk 321 5,41115
4OjOz 185 5,94299
4QrmE 301 5,28554
4QtYJ 299 5,58275
4QxmJ 313 9,77858
4QxnB 271 6,50553
4Tq9z 245 8,63762
4XBlK 306 5,53637
4XRgu 272 5,40433
4XRkH 237 8,34177
4XWi2 245 5,92634
4YisU 237 6,18939
4Yj5Z 318 6,47506
4Yjsg 317 5,93663
4YlA5 269 5,98710
4YwYv 301 5,63180
4YxQS 310 8,29020
4fF9Y 277 10,08100
4kRRi 376 6,51968
4ktGO 305 6,09708
5B1As 212 9,06279
5BC2e 304 8,92624
5H7QD 293 5,96397
5dG7t 202 9,47751
5dG8H 317 6,10635
5i19i 244 6,43908
5j1HC 269 5,75230
5j1NN 281 6,36480
5n9Vr 280 5,35727
5nCAt 264 9,25619
5nCxk 221 8,91322
5nFlZ 252 9,62096
5zkeQ 304 4,87976
6CCDJ 322 6,62950
6CFMz 249 6,25686
6CFuj 310 9,55094
6CGAX 253 8,43764
6CIFz 249 9,42175
6DZ4B 317 9,36482
6Dhr8 248 8,60700
6Dizv 308 8,27370
6Do2r 205 8,72104
6DrWi 300 9,35728
6E0PE 247 7,80469
6EZhk 247 7,86774
6ElnN 253 8,74780
6EqFd 249 8,97505
6F5Tx 251 6,62864
6F66h 253 8,76121
6F6qZ 255 8,72033
6F6rU 253 7,82319
6FkS3 247 8,78686
6H1aA 305 7,81997
6JeAE 317 8,97821
6KIgC 256 8,58114
6KJkE 223 9,77458
6KPc7 271 8,58791
6KWb2 271 10,21419
6KoFY 254 8,74780
6QfRB 325 5,95567
6QxS0 205 4,70601
6Qy1g 265 9,53302
6QycP 234 9,06865
6RYcW 237 9,28127
6Rv4o 355 6,26612
6SIIR 247 9,14763
6SJFb 300 6,76523
6SJg3 305 5,98011
6SMae 304 8,27801
6SVMm 264 8,72111
6T2cr 242 8,31985
6T6sL 289 6,05258
6T6vt 315 6,30455
6T7Xy 235 9,29919
6T866 300 5,40706
6T8OL 289 5,99313
6T8QH 230 7,84421
6T8Th 305 6,45750
6T9EF 290 5,59656
6T9YL 257 9,14041
6T9bQ 289 6,12141
6TGk8 247 9,22931
6TKuf 212 8,88556
6TagR 289 5,52671
6Tb2c 259 7,27286
6Tbam 270 7,40853
6TdTQ 301 5,17186
6Tdoh 300 5,60224
6Tgs8 249 7,78554
6Th9W 253 9,04525
6ThCa 290 5,71257
6ThHv 241 8,41520
6Thoh 279 9,21887
6Ti0Z 244 7,20715
6TifF 257 7,17310
6Ueoc 287 6,36559
6UiQy 320 6,10828
6Vaaj 251 8,85333
6Vb8a 248 8,36202
6Vbim 241 9,22815
6VuJT 294 6,08276
6Vv5S 287 6,48228
6Vwhm 287 6,36571
71YZy 322 7,21283
72UOz 299 9,78438
72ffY 346 6,67190
72qI5 305 6,45432
7AN5n 298 8,86616
7ANFy 317 9,55997
7ANa4 317 9,35973
7ANiN 258 6,74869
7AdPe 336 6,67195
7AdXB 297 9,66486
7AeLZ 331 7,23239
7caCu 310 9,75898
7dJUh 306 9,19875
7dQGS 290 6,49450
7dybV 364 6,01262
7eMeC 299 9,13544
7g3V8 249 8,94249
7o4AK 248 9,43928
7o4F6 299 8,92728
7o4PZ 363 6,49882
7o4Pi 233 9,75382
7o4T4 327 9,54521
7o5Sp 293 7,78470
7o5Xm 304 8,40141
7o6QK 324 10,12129
7o6Ur 293 8,80343
7o7cb 324 5,85421
7p6Ml 308 7,22159
7pyLe 240 8,96280
7qObH 291 9,12539
7qqHg 305 5,78339
7rt3e 314 9,68265
7tNhC 304 9,12745
7tjbm 291 9,01424
7u4IO 299 9,27850
7u4M9 234 9,32040
7uPBK 291 9,14279
7uPWr 261 8,38574
7uPjV 250 9,04448
7uPpr 297 9,78786
7ubXO 364 5,69398
7uc4U 259 9,02946
7ucF6 288 5,91395
7ucLW 302 8,29265
7ucdn 357 8,84824
7uhDH 292 8,88337
7ulxT 247 9,50253
7umEq 321 6,35763
7v1oJ 317 7,82448
7wsM8 307 7,18947
7wy0r 308 8,52519
7xRkO 351 9,36121
7xs1g 311 5,74724
7xuXj 255 8,43751
7yGec 240 8,62492
7zaBv 288 8,94210
7zaUp 285 8,62640
7zcEP 246 7,77851
7zf9x 309 9,23344
7zfWH 238 7,16276
7zgFu 288 7,78393
7zhFM 303 7,75775
7zhbF 310 8,83238
7ziQv 295 9,57641
7ziWU 235 8,74760
7zilQ 298 7,31696
7zinZ 309 9,53257
7zjQN 250 7,76764
7zjeu 308 9,45850
7zjuA 316 9,63146
7zk67 246 9,69361
7zk8d 284 7,16014
7zkNX 257 6,94899
7zkPo 262 8,32598
7zkdT 312 8,92734
7zko8 295 9,13532
8JOms 316 9,35954
8JOmv 317 9,34703
8LCtn 261 7,82532
8Lqh6 337 8,76295
8MCi5 339 9,03023
8MCxA 331 7,77587
8amwZ 265 6,05122
8mvEL 273 10,15901
8mzUN 274 9,47120
8suuL 265 6,30421
QOjc 293 9,39016
bl4i 347 5,80147
bomk 307 5,10348
fKMS 287 5,68335
guUl 237 7,88714
hpKt 319 4,65462
hyF4 283 6,25157
l3dS 235 9,20997
uMD8 301 6,22992
wjSG 308 8,56135
A0A222YW92 336 6,67195
A0A411CFY3 297 9,66486
A0A345L1L5 338 8,89627
A0A345M8H2 331 7,23239
A0A2P1N078 307 7,12894
A0A0S2MU54 313 8,66386
A0A7T8C1R3 337 8,76295
A0A345MG90 331 7,77587
A0A6M3T9G2 340 8,31154
A0A3Q9R4P8 338 9,01108
A0A411C4A9 297 9,66486
A0A4D6E4T0 321 8,75643
A0A7U0GC15 338 9,01115
A0A9E7LSC3 338 9,01108
A0A9E7TBR0 341 7,77974
A0AA96HA54 297 9,66486
A0AAE7XFT4 338 8,90574
A0AAE8BXH0 338 8,90574
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_19071
1jII3
 225 51,2% 250 4.336E-104
2 phalp2_30257
4gSoB
 83 46,8% 222 1.709E-88
3 phalp2_36765
6EBV3
 40 42,7% 222 4.136E-81
4 phalp2_21923
4LFwQ
 4 35,5% 222 4.381E-69
5 phalp2_12100
5yb9X
 1 40,4% 178 4.953E-52
6 phalp2_36860
7gDKs
 246 31,8% 223 1.693E-45
7 phalp2_12497
QM59
 22 30,7% 205 3.097E-42
8 phalp2_11664
1IlHB
 1 30,6% 209 6.298E-40
9 phalp2_25843
5kbTt
 2 30,2% 218 6.825E-38
10 phalp2_37674
4urEs
 29 29,1% 223 1.741E-37

Domains

Domains [InterPro]
Ami2
Representative sequence (used for alignment): 4FizF (237 AA)
Member sequence: A0A345MDV6 (338 AA)
1 237 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptomyces phage SparkleGoddess
[NCBI] 		2283305 Stanwilliamsviridae > Gilsonvirus > Gilsonvirus comrade
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH590589 [NCBI]
CDS location
range 10174 -> 11190
strand +
CDS
ATGGCAACACCAATGACGGCAACACAAATTGTCGCTCAGCTAAAGAAGTGGGGAGTTCCTTATAAGGAGTATAAGGATTGGAAGAACCACAATCGTAATCATATGGGTGCATGGGGTCCTGTAAACGGATTCATGGTTCACCACACAGGTTCCGACAGCAAGGACCAGCGTGAACTACTTTACGCGGGTATTTCTGGTCTTCCTGGTCCACTTTGTCATTTCGGCCTTGCTCAGGATGGAACTGTCCACCTAGTTGGATGGGGAAGAGCAAATCACGCGGGGTCTGGTGACCCAGACGTTCTAAAGGCAGTAATTGATGAGAGCTATGGAGCAAATCCGCCTGTAGACAATCAGTCTTCAGTTGACGGAAATGCAAGGTTCTATGGTGTAGAGATTTGGTATTCGGGAAGTCATGCAATGTCAGCAGCTCAATATGCGACTCTTCGCAAGCTGGCTTCAGCTATTTGCGATTTCCACGGATGGTCAGAAAAGAGCGTTATCGGACATGGCGAATGGGGCAGTCCGGGCAAATGGGACCCCGGCATTTCATCAGGAAAGATGATGGATATGGCAAAGGTTCGTGCAGACGTTAAGTCTACTCTTGGCGGAAGCAAGACGCCTGACCCAGTTCCATCAAAGCCAGCAGATTCAGCAAGCACTCACACAGTTGTTAAGGGAGAAACCCTATGGGCTATCGCTAACAAGTATAAGGTAAGTGTTGACAACCTAAAGAAGTGGAATAGCCTTAAGTCAGATGAGCTATCTGTCGGACAGAAGCTCAAGGTAAAGGCTCCAGCTTCTTCCGGAGGAGGAACATCTACAGTGGCAAAGAAGGACGCAACTTACAAGTCCGTTTGGGATTTGGATGCATCAACTCCACCAAAGGGACATGAGACCACAGCTAACCCAACTTGGGCACCTATGAGCATTCTTCGTGGTATCTATGAAAACCTTGAGACATTGTCTAAGAAGGTTGACGAGCTATCCAAGAAGATTGACGCACTAGAATCTAAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4FizF) rather than this protein.
PDB ID
4FizF
Method AlphaFoldv2
Resolution 95.98
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50