Protein

Protein accession
A0A345M708 [UniProt]
Representative
7ggQn
Source
UniProt (cluster: phalp2_12291)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSTPMSAATFMAALKAEGVDVVEVGDWEHHNRNSKGAWGPVNGVVIHHTVTKGTTNTVNICRDGYSGLPGPLCHGVIAKSGKVYLVGYGRANHAGLGDPDVLAAVIAERKAPVDNEATVDGNAHFYGFECENMGDGKDPWPAAQLEAIERVSAAICRKHGWGELSIIGHLEWQPGKSDPRGFTMDSMRNRVRARLAADPTKPTPPPSTGTTYTVKPGDTLSGIAKALGVTVDALLAANKDKIKDADEIFPGQELTVPKGGSLPKPVKPKVDLSLLVAAAKSNPKASGTPVTYAGVKTVEAALVDEGLLSKTYSDGHYGTTTVEAYRKWQQRCGYTGSDADGIPGKSSLTKLGDKHGFTVVA
Physico‐chemical
properties
protein length:361 AA
molecular weight:37992,5 Da
isoelectric point:7,68
hydropathy:-0,31
Representative Protein Details
Accession
7ggQn
Protein name
7ggQn
Sequence length
354 AA
Molecular weight
38171,56640 Da
Isoelectric point
9,26735
Sequence
MATPPSAATFLKALRDEGLKVVEVGDWRTHNRNHKGPFGPVHGVMIHHTVTKGTANTVKMCRDGYAGLPGPLCHGVIAKDGTVHLVGYGRANHAGMGDDDVLKAVKDQTALPADNEANTDGNRAFYGFECENLGDGKDPWPEAQLEAIEKAAAALCRLHGWDADRVIGHLEWQPGKVDPRGFTMRSMRDRINQRLGSSKPTPPPGQPATGGGTGTYTVRKGDTLFNIARAQQTTVAKLVDLNDLDDPNEISVGQKLKVPAKSTPAPAKPSPSYEPFPGASFFHGGRHSPIITALGRRLVALGFGRHYKNGPGPNWTNADKRNVEDFQRAQGWTGSNADGIPGPETWKRLRIPKV
Other Proteins in cluster: phalp2_12291
Total (incl. this protein): 288 Avg length: 317,1 Avg pI: 8,19
Protein ID Length (AA) pI
7ggQn 354 9,26735
17VTn 262 10,23005
1DV3x 368 6,83196
1GCkI 449 9,25523
1GX4D 313 9,08058
1ICsc 259 9,55952
1glDY 291 6,63177
1gy5P 469 4,81446
1ruZE 249 7,86729
28yez 293 5,89718
2EMFk 251 9,33697
2Sa4K 308 5,70575
2SlxU 366 8,80356
2XDFW 357 5,74400
2YHx2 310 9,58427
2kO7C 366 8,28846
35Lbs 309 8,47999
3LBS2 306 8,32572
3LveF 283 9,44096
3Psw2 308 5,81516
3Q6eo 411 6,63563
3Rzqs 271 5,97926
3VMJD 303 6,66877
3VMKq 302 6,61841
3bZmB 248 9,27631
3dHsO 369 8,82928
3dK7a 314 9,53592
3e4Qe 369 7,82674
3eaq2 303 6,97292
3ebDG 422 9,35805
3ecZF 290 8,57315
3edKo 303 9,04080
3eeGY 243 7,79283
3eeep 422 9,33491
3eyKA 422 9,33491
3ezBR 369 6,46108
3gmn6 392 9,18902
3iEVQ 415 8,95274
402fI 303 8,70847
42vRp 254 6,40333
42voz 305 6,86634
4CMqC 265 4,96195
4E5is 306 9,03939
4HDCh 265 5,02891
4Jm0d 304 8,48612
4KDdk 304 7,30241
4MWw3 242 9,17116
4NbPz 300 9,63759
4OiUt 358 9,84653
4Ojp8 305 5,84233
4QxgA 271 9,99687
4TmEf 309 8,46633
4TqlV 360 8,24223
4XSFP 271 6,54850
4Yji4 362 8,26022
4YmaX 241 5,81363
4kQjz 368 6,00097
4kQsY 327 8,80885
4vhgm 253 4,93007
5Cl5y 313 6,95058
5i0Yo 315 9,09715
5i2n3 353 8,90110
5i3lS 352 8,20426
5inYj 304 7,26200
5zeHE 262 10,30922
6CHr8 305 8,59791
6DhuZ 309 9,44502
6EALf 310 9,57061
6FjtR 321 8,31296
6IbVM 381 7,11297
6Kq3j 374 5,89030
6QYLp 257 11,46385
6RwBb 297 8,55800
6S0xT 332 8,27415
6SLFW 301 8,76179
6T2ci 305 8,98678
6T6AD 309 8,88363
6T6DN 308 8,59642
6T6Wm 401 8,17938
6T71O 204 7,18800
6T7AM 312 8,72259
6T7JL 290 5,89781
6T7ly 303 7,72001
6T7rO 366 9,21384
6T8c0 351 8,80537
6T9bU 305 9,02888
6T9wl 308 8,53266
6TaDU 415 5,48857
6TaQ2 382 8,65812
6TaR5 298 9,15021
6TatU 290 9,28527
6TbJg 305 7,80237
6TbTu 357 8,72813
6Tc8m 362 8,76482
6Tcbi 305 6,75585
6Tchh 308 8,50088
6TdJw 352 9,08800
6TdnX 249 9,29713
6Tdpt 298 9,06253
6Tdqf 399 9,01141
6TduC 195 7,80462
6Tey9 202 8,66811
6Tf3C 311 9,36753
6Tf8Y 308 4,91029
6Tf9J 312 9,13899
6TfTe 399 8,91167
6Tg3v 308 8,28059
6TgdE 307 9,67298
6Tgda 398 7,40808
6TgpK 307 9,50220
6ThKZ 299 8,97956
6ThoR 311 9,36727
6Tijg 309 7,72615
6UdP1 357 8,53640
6UfYh 336 8,78783
6VaXx 308 7,16975
6VbAe 239 8,63736
6VbG5 314 8,91567
6Vbp3 314 9,00593
6XlFq 361 5,63675
726gl 302 9,28088
72yyt 282 9,64120
73dkX 307 7,21204
757fz 278 8,68313
7583h 310 8,88318
75QnV 314 9,34838
792eM 402 8,62189
7AeAe 338 8,89627
7AeHS 338 8,89627
7BKA4 245 6,92170
7BKz5 245 6,25703
7BNuC 304 9,54508
7QtaK 249 9,60400
7baZY 312 9,33175
7dbPm 257 6,17103
7djg7 318 9,66802
7dmsq 350 9,38939
7dr9a 294 7,32589
7dywQ 357 9,27167
7eMfr 301 9,64126
7eMg1 294 6,11874
7eMo2 397 9,04074
7eX7J 256 6,34519
7epLg 310 8,97305
7gCAS 313 8,54601
7gCOg 283 9,51336
7hKER 485 5,17504
7hKFT 316 9,08219
7ha36 303 9,00793
7jD5o 420 9,54559
7jDK7 275 9,51387
7jeSq 249 6,66536
7jf0f 249 6,25731
7l1GL 251 8,58198
7l2SJ 247 9,47016
7l4v5 311 8,75308
7m9ze 315 5,98739
7mHq2 309 8,80962
7maMZ 303 8,32630
7mjw8 399 8,50249
7o598 243 9,13512
7o5Ph 310 8,61802
7o6Ih 306 6,79171
7o6nt 244 9,17116
7o79E 307 9,46623
7o7AA 313 9,05969
7o7kx 351 9,70277
7oia1 290 6,61955
7onDv 397 8,51010
7ouAB 277 7,89726
7pyHF 309 8,29948
7pyKc 311 9,18450
7pyOu 306 8,72162
7qCpG 314 8,99497
7qW3o 323 9,15595
7qry4 305 8,78151
7qrzt 306 6,66843
7rdzY 295 6,78376
7rf9X 291 6,73220
7rt2S 297 9,39390
7u4Le 293 8,92837
7uOZA 312 8,61628
7uP4v 413 7,84479
7uPCV 238 9,51258
7uPbY 315 9,33091
7uPjv 305 7,78412
7uPmA 305 5,31004
7uPoq 310 8,25229
7uPwY 303 9,09631
7ubNv 305 7,25319
7ubR0 298 4,84725
7ubWI 238 6,63097
7ucEm 302 9,44347
7ucUj 243 9,53657
7uclS 390 8,77068
7ucmp 405 8,23785
7udq7 307 6,96104
7uhEx 401 8,68778
7uiJ4 190 9,29952
7ul8n 309 8,27099
7ulDQ 243 9,40125
7wsE5 249 6,92108
7wsO3 312 9,47345
7wswa 306 6,53173
7wsyZ 249 6,30188
7wsyj 306 6,26283
7xLMf 311 9,12481
7xrWX 312 8,25848
7y7BC 313 6,63467
7ygfq 305 9,53160
7zGGc 280 8,29980
7zGIq 401 8,49572
7zGu4 307 7,22426
7zGv8 307 7,22494
7zKFO 401 8,63975
7zaGg 260 9,43580
7zcC1 315 9,19733
7zcNb 306 6,66815
7zcQ7 362 5,63123
7zeXD 305 9,67466
7zf2I 309 8,63691
7zfNA 319 8,77764
7zfP8 306 7,76298
7zgRI 286 5,85205
7zgT6 306 8,44937
7zgW2 306 9,08110
7zgfl 312 8,90452
7zgjG 257 8,85765
7zgwq 318 9,44921
7zhXJ 349 9,70257
7zhed 245 6,40856
7zhpX 309 8,24107
7ziEC 344 5,51136
7ziUS 399 8,69603
7ziYX 345 5,56831
7ziua 312 9,46520
7zj7y 343 5,88724
7zjLy 296 9,35180
7zjY4 314 8,53131
7zk98 305 9,00780
7zkBF 409 8,42848
7zkYT 293 7,69881
7zkx0 270 8,61428
7zmo9 303 9,28288
7zmuQ 411 8,60893
8JOmg 307 7,12894
8JOmo 313 9,07665
8JOmp 335 8,66160
8JOmq 315 9,60097
8JOmr 313 9,22757
8JOmx 422 9,49395
8JOmy 425 9,80076
8MONO 340 8,31154
8MREP 338 9,01108
CFFt 334 8,76262
CG0U 371 9,31215
QQax 314 6,80825
RzKO 405 5,68125
SU2S 360 5,58275
fyqh 365 5,54143
gmG7 241 8,38780
s3C2 368 5,73258
uMwy 359 6,35286
A0A142K646 291 8,35551
A0A0K1Y5X7 275 9,51387
A0A1J0MD01 313 9,07665
K4HYE4 315 9,60097
A0A1J0MCN5 313 9,22757
A0A1J0MBU5 313 9,07665
A0A386K7V8 361 8,23115
A0A386KBJ2 308 9,09528
A0A411AXF9 313 8,89756
A0A411AY00 309 5,87820
A0A4D6E0A3 361 7,67863
A0A6M3T8G4 361 7,72120
A0A6M9Z3I5 314 10,03536
A0A6M9Z4U3 314 10,03536
A0A6M9Z5G4 316 9,97076
A0A7D5G2Y9 314 9,96780
A0A7G4AVS3 313 9,20797
A0A7G4AWM5 308 5,44622
A0A7G9W2I2 309 5,87820
A0A7T0M1N5 361 7,67863
D0UWE9 312 9,47319
A0A976XNH0 297 9,26103
A0AAE7F715 312 6,04331
A0AAF0H2X0 366 8,72929
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_19071
1jII3
 225 43,8% 381 2.799E-118
2 phalp2_2842
8JtqS
 58 41,9% 293 9.620E-94
3 phalp2_36860
7gDKs
 246 30,9% 346 2.267E-48
4 phalp2_12100
5yb9X
 1 27,8% 319 1.257E-46
5 phalp2_2737
7uk55
 6 34,8% 267 3.825E-41
6 phalp2_24820
7loRH
 2 30,1% 352 5.185E-39
7 phalp2_9325
7zgCR
 1 25,1% 350 1.050E-33
8 phalp2_32798
2yYOK
 118 26,8% 358 4.805E-33
9 phalp2_26945
4CQCh
 13 24,0% 358 4.805E-33
10 phalp2_31672
4Kwyh
 4 28,3% 247 4.173E-23

Domains

Domains [InterPro]
Ami2
LysM
Unannotated
Representative sequence (used for alignment): 7ggQn (354 AA)
Member sequence: A0A345M708 (361 AA)
1 354 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476, PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptomyces phage Satis
[NCBI] 		2283264 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH576962 [NCBI]
CDS location
range 77525 -> 78610
strand +
CDS
GTGTCTACCCCGATGAGCGCCGCCACCTTCATGGCAGCGCTGAAAGCGGAAGGTGTCGACGTCGTCGAAGTCGGCGACTGGGAACACCACAACAGGAACTCCAAGGGCGCCTGGGGCCCCGTGAACGGAGTGGTCATCCACCACACCGTGACGAAGGGCACCACGAACACGGTGAACATCTGCCGTGACGGATACTCCGGTCTCCCCGGTCCGCTCTGCCATGGTGTCATCGCCAAGAGCGGCAAGGTCTACCTGGTTGGCTACGGCCGTGCCAACCACGCTGGCCTCGGAGACCCCGACGTTCTGGCGGCGGTCATCGCCGAGCGCAAGGCGCCGGTCGACAACGAAGCCACGGTGGACGGAAACGCGCATTTCTACGGCTTCGAGTGCGAGAACATGGGCGACGGCAAGGACCCCTGGCCCGCCGCTCAGCTCGAAGCGATCGAGCGCGTCTCGGCCGCGATCTGCCGGAAGCACGGATGGGGAGAACTCTCCATCATCGGCCACCTGGAGTGGCAGCCCGGCAAGTCGGACCCTCGTGGCTTCACGATGGACTCGATGCGCAACCGCGTGCGGGCCCGGCTCGCAGCCGATCCGACGAAGCCGACCCCTCCGCCTTCCACCGGCACCACGTACACCGTGAAGCCGGGCGACACCCTGTCGGGGATCGCGAAGGCGCTGGGTGTGACGGTGGACGCCCTGCTCGCGGCCAACAAGGACAAGATCAAGGACGCGGACGAGATCTTCCCCGGCCAGGAGCTGACGGTGCCCAAGGGCGGCTCGCTGCCCAAGCCCGTGAAGCCGAAGGTGGATCTGTCGCTTCTCGTGGCGGCAGCCAAGTCGAATCCGAAGGCTTCCGGCACACCGGTTACGTACGCCGGAGTCAAGACGGTCGAAGCGGCTCTCGTGGATGAAGGTCTGCTCTCGAAGACCTATTCCGACGGGCACTACGGAACCACAACGGTCGAGGCGTACCGCAAGTGGCAGCAGCGGTGCGGGTACACCGGAAGTGATGCCGACGGCATCCCTGGAAAGTCGAGTCTCACTAAGCTCGGCGACAAGCACGGATTCACCGTCGTCGCGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7ggQn) rather than this protein.
PDB ID
7ggQn
Method AlphaFoldv2
Resolution 90.45
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50