Protein

Protein accession
A0A2Z5H5J0 [UniProt]
Representative
2MzZy
Source
UniProt (cluster: phalp2_21629)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTMFPNGAKTAPKVSSPFGPRDPRVGISSQHNGADLIGFEDVHAVEAGTVTHAGWMNDAAGITVVIDHGGGITSLYMHLERVSVGRGRVAEGAKIGEVGSTGNATGDCLHYEIRLHGRSIEPIGWTAARINAGAPAAAAPAYPLPWGSYFGPKSGPRESVSGYYSHREDLRRWQQRMADRGWTINPDGLYGDQTGDVAEAFQREKGLTVDRKIGPATWAAAWTAPVT
Physico‐chemical
properties
protein length:227 AA
molecular weight:24177,7 Da
isoelectric point:6,71
hydropathy:-0,37
Representative Protein Details
Accession
2MzZy
Protein name
2MzZy
Sequence length
394 AA
Molecular weight
40766,21280 Da
Isoelectric point
6,35536
Sequence
VARFPGATWRPLDPQFLPGRRLTVHNRVNLHVTAGTGSPFGTFSRPGAASSHFYVAKDGSVEQFVDTDFQAEGDFDGNDATVSIETEGAAPGVDANAEPWTDAQLAALARLFAWVVSTHGVRVQLASDSKIGDSSKGLSWHRLGIDGNFPALPDQHAGRLQRGGGMHYSTSRGKLCPGNAKIDQIPGILAATGGTILAGSHAGAPVPVPAPAPAPAPVAGTNFGYSAAQIAEAQTLLNQAIGAGLATDGILGPLTKAATVTFQSSHGLTADGIPGPLTVAALHAALTPAPAPAGPVVIAPGVPAPPFPLPVGSYFGPKSGPVASVSGFYSHREDLRRWQQRMHDRGWVINPDGLYGNETAGVAHDFQVEKGLRVDSLIGPITWAAAWTEPITRN
Other Proteins in cluster: phalp2_21629
Total (incl. this protein): 22 Avg length: 314,8 Avg pI: 7,70
Protein ID Length (AA) pI
2MzZy 394 6,35536
1eZP8 326 9,96012
1fUFz 380 4,73858
1fUsO 384 7,60076
1gMsj 321 9,26722
2MzMV 309 7,83434
2b9xZ 318 9,14615
3AyEn 344 9,47861
3XaVQ 385 9,37959
6GBIx 319 9,12803
6Pm9Y 323 7,08966
6UhXs 387 6,06764
6VazD 368 8,85423
fUKR 326 5,81761
hydg 318 8,99387
jGvU 293 5,86944
ouJr 296 10,34758
A0A4Y6ES90 227 6,70748
A0A7L8ZFK0 227 6,70748
A0AA96ZRH0 227 6,70765
A0AAX3DJX1 227 6,70765
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_23479
6PqkT
 19 37,9% 401 1.160E-92
2 phalp2_2602
6IbUl
 53 32,2% 394 1.762E-62
3 phalp2_39542
5FB2E
 5 34,9% 303 9.508E-54
4 phalp2_8051
5Ickg
 15 28,3% 413 2.288E-39
5 phalp2_28100
7ukr9
 2 32,1% 271 4.809E-26
6 phalp2_7198
3ejcO
 5 24,2% 413 1.167E-18
7 phalp2_13713
6Ajj7
 6 26,6% 266 4.945E-15

Domains

Domains [InterPro]
Ami2
PG_1
Unannotated
Representative sequence (used for alignment): 2MzZy (394 AA)
Member sequence: A0A2Z5H5J0 (227 AA)
1 394 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01471, PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Microbacterium phage KayPaulus
[NCBI] 		2250350 Orlajensenviridae > Paopuvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH371118 [NCBI]
CDS location
range 13638 -> 14321
strand +
CDS
ATGACCATGTTCCCCAACGGGGCCAAGACCGCCCCGAAGGTGTCGAGTCCGTTCGGCCCCCGTGATCCCCGCGTGGGGATCAGCTCGCAGCACAACGGCGCTGACCTGATCGGGTTCGAGGACGTTCACGCCGTCGAGGCCGGCACGGTCACGCACGCCGGCTGGATGAACGACGCGGCCGGCATCACCGTGGTGATCGACCACGGCGGCGGCATTACGTCGCTCTACATGCACCTGGAACGCGTCAGCGTCGGCCGTGGCCGCGTGGCCGAGGGCGCGAAGATCGGAGAGGTCGGCAGCACCGGCAACGCGACCGGGGACTGCCTGCACTACGAGATCCGCCTGCACGGCCGCAGCATCGAGCCGATCGGCTGGACGGCTGCCCGGATCAACGCCGGCGCGCCGGCTGCAGCTGCGCCCGCGTACCCGCTGCCGTGGGGATCGTACTTCGGCCCCAAGTCCGGCCCCCGCGAGAGCGTCAGCGGCTACTACTCGCACCGCGAGGATCTGCGCCGCTGGCAGCAGCGCATGGCAGATCGCGGCTGGACGATCAACCCGGATGGTCTCTACGGCGATCAGACCGGCGACGTGGCCGAGGCGTTCCAGCGCGAGAAGGGTCTGACCGTCGATCGCAAGATCGGCCCCGCCACGTGGGCGGCTGCCTGGACGGCCCCCGTCACGTGA

Gene Ontology

Description Category Evidence (source)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2MzZy) rather than this protein.
PDB ID
2MzZy
Method AlphaFoldv2
Resolution 84.53
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50