Protein

Protein accession
A0A2Z5H0J6 [UniProt]
Representative
8HwAL
Source
UniProt (cluster: phalp2_1210)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSFRTAYGNAYSENGWRMCNRDECVTVSGPYMNTAPLRRGPAEKLLGEFVRRYHQVCAPVVSPVWGWSETNDVGNSNHLSGTAVDVNAPQWPWGLRKMPADLVARINVLLDQFEGAIYWGRNWNRPDEMHFQLNWREGDAKYDRIIAKFSGGSVPVTPHVPNLPTDDSELLMRGSANVEQTRILQAGLKKVFPAYAGHLEVDGDYGPETEKAVRRFQSGSGLVADGIVGPATRAELAKYNIILKPAAPQEIIPVGKTPVVVGPADDQLNMRFNCLGGKTLVEAVAEIRDAVCGTNDKDKTGVVLK
Physico‐chemical
properties
protein length:305 AA
molecular weight:33533,7 Da
isoelectric point:6,54
hydropathy:-0,35
Representative Protein Details
Accession
8HwAL
Protein name
8HwAL
Sequence length
313 AA
Molecular weight
34804,28630 Da
Isoelectric point
7,05528
Sequence
MYPNRKAHMSFRTVYGHDWSENGWRMCNRDECVVVAGPFMNTAPLRRGPAEILLGEFVRRYHAVCAPVVSSVWGWSEENDVGNSNHLSGTAVDINAPQWPWGLKKMPADLIARINVLLDFFEGSIYWGRNWNRPDEMHFQLNWPEGDARYARILQKITGAPPVTPHVPNLPQDDSELLMRGSANAEQTCILQNGLKKVFPSYAGHLAVDGDYGPETEKAVRRFQSATPGLVADGIVGPQTRAALAKYNIILKPATPEKVIIVDKQPVIVGPADDQLNMRWNRLGGKTLVEAVAEIRDAVTGSKDKDKEGVVLK
Other Proteins in cluster: phalp2_1210
Total (incl. this protein): 40 Avg length: 283,9 Avg pI: 7,10
Protein ID Length (AA) pI
8HwAL 313 7,05528
2Hsg5 239 10,06721
7AKwH 304 6,13556
7Q0NN 305 6,53764
7iGL7 238 9,67872
7jI4G 305 6,53764
7o38U 235 9,33220
7o3nR 237 9,60677
7o3zP 237 9,88560
7zR2U 304 5,67619
8HwAJ 305 6,53764
8HwAP 304 5,88667
8HwAT 287 6,12994
G1EDU3 313 7,05528
A0A514U2A8 304 6,13556
A0A076YPB7 305 6,53764
A0A0N7GFJ7 305 6,53764
H9NCS1 304 5,67619
A0A4D6T5C6 177 8,71002
G1JUI2 305 6,53764
A0A2H4PG52 304 5,88667
A0A2H4PFF0 304 6,45318
G1JX41 315 5,01595
A0A386KHH0 177 7,84833
A0A6B9T037 177 8,71002
A0A2R4ANE7 305 6,53764
A0A2R4APH6 313 8,65851
A0A2R4AQ01 305 6,53764
A0A2Z5H220 305 6,53764
A0A411AX57 305 6,53764
A0A5Q2W9Z9 305 6,53764
A0A649VIR9 288 6,23623
G1BQ52 305 6,53764
G1EDF4 313 7,73808
I6WIA4 313 7,73808
S5Y8Q2 305 6,53764
A0A9E7T0M0 177 7,84833
A0AA96GRA7 305 6,96126
A0AA96GVL8 304 6,45318
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_12264
727mo
 153 36,1% 238 3.832E-43
2 phalp2_11272
6Q92e
 9 29,8% 231 1.150E-15
3 phalp2_34088
8kbAa
 16 27,5% 232 2.322E-12

Domains

Domains [InterPro]
PET_M15
PG_1
Disordered region
Representative sequence (used for alignment): 8HwAL (313 AA)
Member sequence: A0A2Z5H0J6 (305 AA)
1 313 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01471, PF13539

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage Dublin
[NCBI] 		2234073 Benedictvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH338235 [NCBI]
CDS location
range 4408 -> 5325
strand +
CDS
ATGAGCTTCCGCACTGCTTATGGCAATGCGTACTCCGAGAACGGTTGGCGTATGTGCAACCGCGACGAGTGCGTGACGGTCTCCGGACCGTACATGAACACCGCGCCGCTACGACGTGGTCCTGCCGAGAAGCTCCTCGGAGAGTTCGTCAGGCGCTACCACCAGGTATGTGCCCCGGTCGTGTCCCCGGTGTGGGGCTGGTCGGAGACGAACGATGTGGGCAACTCGAATCACCTGTCGGGCACCGCAGTTGACGTCAACGCACCGCAGTGGCCTTGGGGCCTTCGCAAGATGCCCGCTGACCTGGTTGCGCGGATCAACGTGCTGCTGGACCAGTTCGAGGGTGCGATCTATTGGGGTCGCAACTGGAACCGTCCGGACGAGATGCACTTCCAGCTCAACTGGCGGGAGGGTGACGCCAAGTACGACCGGATCATCGCGAAGTTCAGCGGCGGTAGCGTCCCGGTCACCCCGCACGTCCCCAATCTGCCTACCGACGACAGCGAACTGCTCATGCGCGGTTCGGCCAACGTCGAGCAGACCCGCATCCTCCAGGCAGGACTCAAGAAGGTGTTCCCCGCGTACGCCGGTCACCTGGAGGTCGACGGCGACTACGGCCCCGAGACGGAGAAGGCGGTTCGCCGCTTCCAGTCAGGATCCGGTCTGGTGGCAGACGGCATCGTCGGTCCGGCCACCCGAGCCGAGCTCGCCAAGTACAACATCATCCTCAAACCCGCTGCGCCACAGGAGATCATCCCCGTGGGTAAGACACCAGTTGTTGTCGGCCCTGCCGACGACCAGCTCAACATGCGGTTCAACTGCCTCGGTGGCAAGACGCTTGTCGAAGCCGTCGCCGAGATCCGAGATGCAGTGTGCGGCACGAACGACAAGGACAAGACAGGCGTGGTGCTTAAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0008233 peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8HwAL) rather than this protein.
PDB ID
8HwAL
Method AlphaFoldv2
Resolution 81.94
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50