Protein

Protein accession
A0A2Z3EAE0 [UniProt]
Representative
1hMzx
Source
UniProt (cluster: phalp2_29706)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MGFKMKYSIKQDYLPSGSLRRPGIRMSKVAHVVAHDTGNPGSSAQGNVNYYRNSAYEMEASAQLFVDDKNIIECIPALLNPPEKAWHVRYNSPNEKKWYGASNDQAIGVELCFGGSINFEEAYKRYLWVIAYICYKYGFSPTRVIGHEKLDPGRKVDPSAGLRVGGRTYDQLMRDIVAEYNDCTDGSSYEPPASGGNQGGGNSADGSIGIVRTKVNLNFRKEPNTSSEIIKTLPANTEWICWAEKDGWYNLGGGWVFGSSEYATFISNGTSTPTPPPVTPPSGGSQAVTGVAYITADVLNVRSEPSTNAAIVKKVYNGESYKVFAKQGDWYNVGGNQWISANYVRFVPDGSSAPVTGTAYIKADVLNVRNRPSMDGTVVKKVYNGEAYKVFAKSGDWYCVGGDQWISANSEYVRFVSN
Physico‐chemical
properties
protein length:418 AA
molecular weight:45810,6 Da
isoelectric point:8,31
hydropathy:-0,46
Representative Protein Details
Accession
1hMzx
Protein name
1hMzx
Sequence length
292 AA
Molecular weight
32785,90840 Da
Isoelectric point
8,75360
Sequence
MSFKMKYEITKKYLTSGTKRRSGIKMPSVKFVVAHDTGNKGSTALNNVTYYENTKNETSASAHLFVDDKFIYECIPALTGTPEKAWHVLYNKTKDNELYGDDSNDVAIGVEYCYGNNINSAESYKRYVWVIAYICYKFNLDPKKAITAHFILDPQRKSDPKSGLADSGRTYEQLLKDIVSEYEDCTKPEIVSPVVNPPVLPDIPTKIIFTSDNQVVDGFMRNGSNYIPASTLRDKLGDILEWNNNNKILKVNGTQVTAIMKDGMNYVSAQSVISLGHKVTPNGVNKKLYISK
Other Proteins in cluster: phalp2_29706
Total (incl. this protein): 5 Avg length: 287,2 Avg pI: 8,02
Protein ID Length (AA) pI
1hMzx 292 8,75360
2tI5r 247 6,52025
7xkxx 292 8,28079
A0A6J7WLT7 187 8,21168
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_6407
bpom
 66 62,4% 181 5.112E-82
2 phalp2_321
6SgOZ
 68 46,1% 193 1.017E-53
3 phalp2_18561
73HNe
 82 38,8% 198 8.871E-38
4 phalp2_9318
7vPuw
 15 25,9% 285 8.670E-19
5 phalp2_22283
7wMS5
 3 26,9% 301 1.039E-16
6 phalp2_39055
7ordh
 68 28,6% 185 1.123E-15
7 phalp2_27158
38a6k
 24 26,2% 187 4.952E-15
8 phalp2_424
7xFGZ
 10 31,4% 197 1.278E-13
9 phalp2_13982
kgnW
 11 27,9% 197 3.091E-13
10 phalp2_23523
75EkF
 74 26,9% 252 1.801E-12

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 1hMzx (292 AA)
Member sequence: A0A2Z3EAE0 (418 AA)
1 292 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacillus phage vB_BceM-HSE3
[NCBI] 		2170705 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MF418016 [NCBI]
CDS location
range 87297 -> 88553
strand +
CDS
ATGGGTTTCAAAATGAAGTATAGTATTAAACAAGATTATTTACCTTCAGGTTCTTTACGTAGACCTGGTATCCGTATGTCAAAAGTAGCTCACGTAGTAGCTCATGATACAGGTAATCCTGGATCATCTGCACAGGGTAACGTAAACTACTACCGTAATTCTGCTTACGAGATGGAAGCATCAGCTCAGCTTTTCGTTGATGACAAGAACATCATCGAGTGTATTCCAGCATTATTGAATCCACCTGAGAAAGCTTGGCATGTTCGTTATAACTCTCCTAATGAGAAGAAATGGTACGGAGCTTCTAATGATCAGGCTATCGGAGTTGAATTATGTTTCGGTGGTAGCATCAACTTTGAAGAAGCTTATAAACGTTATCTATGGGTAATCGCTTATATCTGTTACAAGTATGGATTTTCTCCTACTAGAGTAATCGGTCACGAAAAGTTAGATCCAGGTCGTAAGGTCGATCCTAGTGCAGGTCTACGAGTAGGTGGACGTACTTATGATCAACTCATGAGAGATATTGTTGCTGAGTACAATGACTGTACTGACGGTTCTTCTTATGAGCCACCAGCTAGTGGAGGTAATCAAGGTGGAGGTAATTCAGCTGATGGATCTATTGGTATTGTTCGTACGAAAGTTAACTTGAACTTCCGTAAAGAGCCTAATACATCATCAGAGATTATCAAGACTTTACCTGCTAACACTGAGTGGATCTGTTGGGCTGAGAAAGATGGTTGGTACAACTTAGGTGGAGGATGGGTATTCGGTAGCTCTGAATATGCTACTTTCATTAGTAACGGAACTTCAACTCCGACTCCACCCCCAGTAACTCCGCCATCAGGAGGATCTCAAGCAGTAACTGGAGTTGCTTACATTACTGCTGATGTTCTTAACGTACGTAGTGAGCCTTCTACTAATGCAGCAATCGTTAAGAAAGTATACAATGGTGAATCTTATAAAGTATTCGCTAAGCAAGGTGACTGGTACAATGTTGGTGGTAATCAATGGATCTCAGCTAATTATGTTAGATTCGTTCCAGATGGAAGCTCAGCTCCTGTGACTGGTACTGCTTACATTAAAGCTGATGTTCTTAACGTACGTAACCGACCTTCTATGGACGGAACAGTCGTTAAGAAAGTCTATAATGGTGAAGCTTATAAAGTATTTGCTAAGAGTGGCGACTGGTATTGTGTAGGAGGAGACCAGTGGATTTCAGCTAACTCTGAGTATGTTAGATTCGTATCTAACTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0006508 proteolysis biological process None (UniProt)
GO:0008233 peptidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1hMzx) rather than this protein.
PDB ID
1hMzx
Method AlphaFoldv2
Resolution 91.57
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50