Protein

Protein accession
A0A222ZHL5 [UniProt]
Representative
5kHaZ
Source
UniProt (cluster: phalp2_14600)
Protein name
Endolysin, L-Ala-D-Glu peptidase domain
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTTMTLAYPLVEGETIQEFGARQSFYRKLGQLGHNGIDLGCEVGTPVYAMAAGTVLHAGWSHDHPWLTHHAGIAVLTHHGEHISGLAHLSKVVVAPGDRVEVGQLVGYSGDTGTAGVPHVHCELLEAQPDWSNGYAGRIRFEFSKGELN
Physico‐chemical
properties
protein length:149 AA
molecular weight:16005,8 Da
isoelectric point:5,89
hydropathy:-0,12
Representative Protein Details
Accession
5kHaZ
Protein name
5kHaZ
Sequence length
251 AA
Molecular weight
27245,03030 Da
Isoelectric point
5,95794
Sequence
LSIWWPVDNPRITGDFGVDPDFYAQFGQRGHNGIDLGVGVGTPVFSTDAGVVEFEGWGQNHSWMGRIAGISIILRHGWGYSGYAHLNSTVVNRGQSVARGQLIGYSGQTGVGTGPHLHFETFPPNPNFGNGFAGRINPRGFGLVARGGQPAPEPSPIDIGDDEMYSIARLDDGWAALWNMATGEFRHIDTPEDYRRFSAALKIYQFANLGAFEAFRNKYPFLVKVTAANVSVDAAAVAKAVNDDVSRRMAQ
Other Proteins in cluster: phalp2_14600
Total (incl. this protein): 35 Avg length: 151,7 Avg pI: 6,16
Protein ID Length (AA) pI
5kHaZ 251 5,95794
A0A0U4K335 148 6,27959
A0A222ZHW0 148 6,27959
A0A222ZGW3 149 6,00950
A0A0M4R0N4 148 6,27959
A0A0M4S3J8 148 6,27959
A0A0P0IQA3 148 6,27959
A0A0U4B6V5 148 6,27959
A0A0U4JSN5 148 6,27959
A0A0U4JZV3 148 6,27959
A0A0U4K185 148 6,27959
A0A1B2IHI6 148 6,27959
A0A1C9LZN8 148 6,27959
A0A1D8EY20 148 6,27959
A0A1S6L2H3 148 6,27959
A0A221J6Q1 149 6,00950
A0A221J6U0 148 6,27959
A0A222ZFR0 148 6,27959
A0A222ZG71 148 6,27959
A0A222ZGZ7 149 6,00950
A0A345M411 148 6,27959
A0A345M4C7 148 6,27959
A0A345M4F3 148 6,27959
A0A345M4H9 148 6,27959
A0A345M596 148 6,27959
A0A345M5R7 148 6,27959
A0A345M6N0 148 6,27959
A0A386KFG9 148 6,27959
A0A4P8MUW3 148 6,27959
A0A5Q2WFF0 149 6,00950
A0A6B9L7W7 148 6,27959
A0A9E7QFL6 155 5,54063
A0AA96NI75 155 5,54063
A0AA96QZW5 155 5,54063
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33817
1joRs
 29 36,7% 185 8.851E-29
2 phalp2_38873
1OvVW
 15 38,0% 163 8.998E-19
3 phalp2_11348
7sGwF
 5 31,4% 175 1.880E-17
4 phalp2_33099
4HIDS
 1 38,0% 155 3.449E-17
5 phalp2_32733
8iF6d
 6 32,9% 176 1.301E-15
6 phalp2_25136
1CoHT
 3 27,2% 191 9.396E-09

Domains

Domains [InterPro]
PET_M23
Disordered region
Representative sequence (used for alignment): 5kHaZ (251 AA)
Member sequence: A0A222ZHL5 (149 AA)
1 251 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Arthrobacter phage KylieMac
[NCBI] 		2015859 Decurrovirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MF140415 [NCBI]
CDS location
range 11594 -> 12043
strand +
CDS
ATGACAACAATGACGCTTGCCTATCCGCTCGTTGAGGGCGAGACAATCCAAGAGTTCGGTGCCCGTCAGTCGTTCTACCGGAAACTTGGGCAGCTTGGGCACAACGGCATAGACCTTGGTTGCGAGGTTGGCACCCCGGTCTATGCCATGGCAGCCGGCACCGTGCTACATGCCGGTTGGTCCCACGATCACCCATGGCTGACCCATCATGCCGGCATTGCCGTCCTGACCCATCACGGCGAACACATCAGCGGCCTAGCGCACCTATCCAAGGTTGTGGTGGCACCCGGTGACCGTGTGGAGGTTGGGCAGCTCGTCGGCTACTCAGGGGACACCGGCACCGCCGGCGTGCCCCACGTGCACTGTGAGCTGCTGGAAGCACAGCCGGATTGGTCCAACGGTTACGCCGGCCGCATCCGTTTCGAGTTCAGCAAAGGAGAGCTAAATTGA

Gene Ontology

Description Category Evidence (source)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000b94dc86_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (5kHaZ) rather than this protein.
PDB ID
5kHaZ
Method AlphaFoldv2
Resolution 73.53
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50